MCSP TORFP NO. NIH-NINDS-21-01: FLORIO (ANAGIN) - BASE EC (STROKE)

承包商在履行本协议项下的工作时 任务单应提供全方位服务设施和支持药物化学的工作人员 从化学探索性阶段开始的发现计划以发展结构活动 关系(SAR)分析和设计、合成、体外吸收、分布、代谢 排泄与毒理学(ADMET)、计算化学/计算机辅助药物发现 (CAD)和仓储和运输复合物流，以支持贡献者Florio (Anagin)开发一种新的治疗中风的有效药物。这将通过推进 它们的小分子杂环起始化合物的SAR/SPR 体外ADMET以确定针对靶标酶的新型选择性抑制物 缺血性中风。此药物化学支持计划(MCSP)任务订单的范围 应在业绩范围2：药物化学支持下提供药物化学服务 为支持NIH、NINDS及其贡献者支持的临床前药物发现工作 (如父SOW中所述)。

The Contractor, in performance of work under this task order shall provide a full-service facility and staff who would support a medicinal chemistry discovery program beginning at the Exploratory Chemistry phase to develop structure activity relationship (SAR) analysis and design, synthesis, in vitro absorption, distribution, metabolism, excretion and toxicology (ADMET), computational chemistry/Computer Aided Drug Discovery (CADD) and compound logistics of storage and shipping to support the Contributor Florio (Anagin) to develop a novel therapeutic effective in stroke. This will be achieved by advancing the SAR/SPR of their small molecule heterocyclic starting compound utilizing their assays and in vitro ADMET to identify novel, selective inhibitors of the target enzyme that are directed at ischemic stroke. The scope of this Medicinal Chemistry Support Program (MCSP) task order shall be medicinal chemistry services under Performance Area 2: Medicinal Chemistry Support in support of preclinical drug discovery efforts supported by NIH, NINDS and its Contributors (as outlined in the Parent SOW).