Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner

物种特异性方式的接头介导的整合素信号转导的分子机制

• 批准号: 10591322
• 负责人: Jinhua Wu
• 金额: $ 6.94万
• 依托单位: RESEARCH INST OF FOX CHASE CAN CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591322
• 关键词: Administrative Supplement; Autoimmune Diseases; Cardiovascular Diseases; Circular Dichroism; Data; Disease; Ensure; Funding; Grant; Hyperactivity; Impairment; Inflammatory Response; Integrins; Lead; Mediating; Molecular; National Institute of General Medical Sciences; Neoplasm Metastasis; Productivity; Research; Research Project Grants; Signal Transduction; Thrombosis; design; equipment acquisition; inhibitor; peptidomimetics; tumor

Project Summary This is a request for an NIGMS Administrative Supplement to NIGMS grant R35GM119560, to purchase a J- 1100 Circular Dichroism (CD) Spectropolarimeter. Our previous structural and functional studies allow us to design peptidomimetic inhibitors targeting integrin-related diseases such as thrombotic disorders, cardiovascular diseases, and many autoimmune diseases. Our data suggest the helicity of the peptidomimetics is required for its inhibitory function. Access to the J-1100 CD Spectropolarimeter will provide the necessary capabilities to maximize productivity and fully achieve the aims of the proposed research project. Institutional matching funds will contribute to the purchase of this instrument.

项目概要 这是对 NIGMS 拨款 R35GM119560 的 NIGMS 行政补充申请，以购买 J- 1100 圆二色性 (CD) 分光偏振计。我们之前的结构和功能研究使我们能够 设计针对整合素相关疾病（如血栓性疾病、心血管疾病）的拟肽抑制剂 疾病，以及许多自身免疫性疾病。我们的数据表明肽模拟物的螺旋性对于 其抑制作用。使用 J-1100 CD 分光旋光计将提供必要的功能 最大限度地提高生产力并充分实现拟议研究项目的目标。机构配套资金 将有助于购买该仪器。