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Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner

Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner
物种特异性方式的接头介导的整合素信号转导的分子机制
批准号:
10792668
负责人:
Jinhua Wu
金额:
$6.67万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
未结题
起止时间:
2016-09-01 至 2026-12-31

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英文摘要
Project Summary This is a request for an NIGMS Administrative Supplement to NIGMS grant R35GM119560, to purchase a miniDAWN Multi-Angle Light Scattering (MALS) Detector from Wyatt Technology. Our previous structural and functional studies of integrin signaling pathway reveal that integrin activity is tightly regulated by a few signaling adaptor proteins. Formation of protein complexes or protein homo-oligomers mediates the signal transduction that leads to integrin activation and clustering. With the miniDAWN MALS detector, we can monitor the formation of these complexes/oligomers by accurately determining the absolute molar masses and sizes of protein macromolecules in solution. The instrument will provide the necessary capabilities to maximize productivity and fully achieve the aims of the proposed research project. Institutional matching funds will contribute to the purchase of this instrument.
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Novel Regulatory Mechanisms Underlying Inside-out Integrin Activation
Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner
Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner
Molecular Mechanisms Underlying Adaptor-Mediated Integrin Signaling in a Species-Specific Manner
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