Human Microbiome and its Role in the Development of Lumbar Spine Degeneration and Modic Changes

总结 慢性腰痛（LBP）是世界上最致残的疾病，其管理 结果往往不能令人满意，全世界的保健费用是天文数字。Modic 改变类型1（MC 1：邻近终板的软骨下骨髓病变， 与炎症相关）的磁共振成像（MRI）与 慢性LBP的发展和严重程度。MC 1的病因仍然是推测性的。 全身炎症和代谢组学生物标志物与MCI相关;然而， 还在调查中椎间盘退变（DD）通常与以下因素相关： 细菌入侵，但不能复制和可疑。人类的微生物组 与一系列人类疾病有关以下建议旨在确定腰椎 MC 1与肠道微生物组的促炎性质相关， 非MC 1椎间盘。考虑到微生物组的综合方法， 代谢组学和全身炎症标志物也将在MCI的相关性， 腰椎

Summary Chronic low back pain (LBP) is the world’s most disabling condition, whose management outcomes are often unsatisfactory and health-care costs worldwide are astronomical. Modic changes Type 1 (MC1: subchondral bone marrow lesions adjacent to the endplate that are associated with inflammation) on magnetic resonance imaging (MRI) are highly associated with the development and severity of chronic LBP. The etiology of MC1 remains speculative. Systemic inflammatory and metabolomic biomarkers have been associated with MCI; however, still under scrutiny. Intervertebral disc degeneration (DD) in general has been associated with bacterial invasion, but not replicated and questionable. The human microbiome has been associated with a string of human diseases. The following proposal aims to identify if lumbar MC1 are associated with the pro-inflammatory nature of the intestinal microbiome compared to non-MC1 intervertebral discs. Integrative approaches taking into account the microbiome, metabolomics and systemic inflammatory markers will also be addressed in relation to MCI of the lumbar spine.