The Human Microbiome and Its Role in Musculoskeletal Disorders.
The Human Microbiome and Its Role in Musculoskeletal Disorders.
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DOI：
10.3390/genes14101937
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发表时间：
2023-10-14
期刊：
影响因子：
3.5
通讯作者：
Samartzis, Dino
中科院分区：
文献类型：
--
作者：
Aboushaala, Khaled;Wong, Arnold Y. L.;Barajas, Juan Nicolas;Lim, Perry;Al-Harthi, Lena;Chee, Ana;Forsyth, Christopher B.;Oh, Chun-do;Toro, Sheila J.;Williams, Frances M. K.;An, Howard S.;Samartzis, Dino
肌肉骨骼疾病（MSDs）的特征是影响肌肉骨骼系统的损伤和疾病。msd影响到全世界所有人口，并与巨大的全球负担相关。肠道菌群组成的变化可能与慢性MSDs有关。人们对探索慢性MSDs与肠道微生物群组成变化之间的潜在联系越来越感兴趣。人体微生物群是一个由病毒、古生菌、细菌和真核生物组成的复杂群落，存在于人体内和体外。这些微生物在影响人体生理，影响健康和疾病的代谢和免疫系统方面起着至关重要的作用。不同的身体部位有特定类型的微生物，兼性厌氧菌主导胃肠道（有氧或无氧都能茁壮成长），而严格的需氧菌主要存在于鼻腔、呼吸道和皮肤表面（发育需要氧气）。随着时间的推移，这些细菌与免疫系统一起共同进化，形成了复杂的生物关系。肠道微生物生态的变化可能会对健康产生重大影响，并可能导致疾病的发展。这些变化经常受到生活方式选择和潜在疾病的影响。以微生物群为基础的药物，即使是偶尔给药，其安全性、费用和疗效的潜力也引起了人们的兴趣。因此，它们是治疗慢性和可能有不同进展模式的MSDs的理想候选药物。因此，以下是一篇叙述性综述，以解决与MSDs相关的人类微生物组的作用。
Musculoskeletal diseases (MSDs) are characterized as injuries and illnesses that affect the musculoskeletal system. MSDs affect every population worldwide and are associated with substantial global burden. Variations in the makeup of the gut microbiota may be related to chronic MSDs. There is growing interest in exploring potential connections between chronic MSDs and variations in the composition of gut microbiota. The human microbiota is a complex community consisting of viruses, archaea, bacteria, and eukaryotes, both inside and outside of the human body. These microorganisms play crucial roles in influencing human physiology, impacting metabolic and immunological systems in health and disease. Different body areas host specific types of microorganisms, with facultative anaerobes dominating the gastrointestinal tract (able to thrive with or without oxygen), while strict aerobes prevail in the nasal cavity, respiratory tract, and skin surfaces (requiring oxygen for development). Together with the immune system, these bacteria have coevolved throughout time, forming complex biological relationships. Changes in the microbial ecology of the gut may have a big impact on health and can help illnesses develop. These changes are frequently impacted by lifestyle choices and underlying medical disorders. The potential for safety, expenses, and efficacy of microbiota-based medicines, even with occasional delivery, has attracted interest. They are, therefore, a desirable candidate for treating MSDs that are chronic and that may have variable progression patterns. As such, the following is a narrative review to address the role of the human microbiome as it relates to MSDs.
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DOI：
10.1016/j.bbi.2018.09.018
发表时间：
2019-01
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Albrecht DS;Forsberg A;Sandström A;Bergan C;Kadetoff D;Protsenko E;Lampa J;Lee YC;Höglund CO;Catana C;Cervenka S;Akeju O;Lekander M;Cohen G;Halldin C;Taylor N;Kim M;Hooker JM;Edwards RR;Napadow V;Kosek E;Loggia ML
通讯作者：
Loggia ML
影响因子：
--
作者：
Biagi, Elena;Candela, Marco;Fairweather-Tait, Susan;Franceschi, Claudio;Brigidi, Patrizia
通讯作者：
Brigidi, Patrizia
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
3
作者：
Chou, Dean;Samartzis, Dino;Skelly, Andrea C.
通讯作者：
Skelly, Andrea C.
影响因子：
16.6
作者：
Boer, Cindy G.;Radjabzadeh, Djawad;van Meurs, Joyce B. J.
通讯作者：
van Meurs, Joyce B. J.