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Preclinical Models Core

临床前模型核心

基本信息

批准号：
10617220
负责人：
Tatiana Kisseleva
金额：
$ 26.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10617220
关键词：
Animal Experimentation Animal Model Animals Area Autopsy Biological Assay Biological Markers California Clinical Data Clinical Pathology Comparative Pathology Complement Consult Consultations Core Facility Data Analyses Development Digestive System Disorders Disease Doctor of Philosophy Experimental Designs Funding Gastrointestinal Diseases Gastrointestinal tract structure Gene Expression Genetic Predisposition to Disease Health Histology Histopathology Human Image Imaging Techniques Infection Inflammation Infrastructure Leadership Liver Liver diseases Medicine Methods Microscopy Mission Modeling Monitor National Institute of Diabetes and Digestive and Kidney Diseases Outcome Pathology Patients Pre-Clinical Model R24 Records Research Research Personnel Resources Role Scientist Services Stains Surveys System Techniques Training Translating Universities Veterinarians animal imaging comparative cost effective data acquisition disease phenotype experience functional genomics gastrointestinal system human disease in vivo in vivo imaging insight instrumentation lectures member microbiome research mouse model patient population pre-clinical pre-clinical research preclinical study programs prospective recruit repository research faculty sample fixation skills success tissue preparation veterinary science

项目摘要

Summary The Preclinical Models Core in the San Diego Digestive Diseases Research Center will provide access to animal models of gastrointestinal and liver disease for preclinical studies and will assist in characterizing disease activity prospectively and retrospectively in a comprehensive and uniform manner. The Core emanated out of core services provided by a past NIDDK-funded (R24) Mini-Center at the University of California, San Diego (UCSD). The approach to create the Preclinical Models Core is based on information from surveys of Center member needs, experience with the prior Mini-Center at UCSD, the broad expertise of Center members in digestive diseases research, and the insights of several of the Center members who have served as advisors or in leadership roles for other Silvio O. Conte Centers. The Core will provide resources in veterinary sciences and a technical infrastructure that enables animals to be studied comprehensively. The services will include consultation on the selection and interpretation of animal models of digestive diseases, ante-mortem imaging and post-mortem examination, including the development and interpretation of scoring systems by veterinarians trained in comparative pathology. Thus, the Core will truly be “preclinical” in that it will be modeling and evaluating disease with instrumentation also used in patients with the added advantage of the controlled manipulations that are possible in these models. The Core will be led by two experienced leaders with strong track records in applying animal models to basic and preclinical questions: Dr. Peter Ernst, a PhD veterinarian with extensive experience in managing Core facilities, will be the Core Director and focus on murine models of gastrointestinal disease and in vivo imaging. As the Core Co-Director, Dr. Tatiana Kisseleva will provide her extensive experience with animal models of liver disease. Furthermore, the Core will interact with and directly complement the Human Translational and Microbiomics and Functional Genomics Cores by being able to relate the imaging results, biomarkers and clinical data to specific outcomes in animal models and human disease. Thus, the Preclinical Models Core will benefit the investigators in the Center by providing reliable, cost-effective services that are coordinated with the investigators’ research and other Cores to facilitate and advance research related to the gastrointestinal tract and liver.

总结