Preclinical Models Core
临床前模型核心
基本信息
- 批准号:10617220
- 负责人:
- 金额:$ 26.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:Animal ExperimentationAnimal ModelAnimalsAreaAutopsyBiological AssayBiological MarkersCaliforniaClinical DataClinical PathologyComparative PathologyComplementConsultConsultationsCore FacilityData AnalysesDevelopmentDigestive System DisordersDiseaseDoctor of PhilosophyExperimental DesignsFundingGastrointestinal DiseasesGastrointestinal tract structureGene ExpressionGenetic Predisposition to DiseaseHealthHistologyHistopathologyHumanImageImaging TechniquesInfectionInflammationInfrastructureLeadershipLiverLiver diseasesMedicineMethodsMicroscopyMissionModelingMonitorNational Institute of Diabetes and Digestive and Kidney DiseasesOutcomePathologyPatientsPre-Clinical ModelR24RecordsResearchResearch PersonnelResourcesRoleScientistServicesStainsSurveysSystemTechniquesTrainingTranslatingUniversitiesVeterinariansanimal imagingcomparativecost effectivedata acquisitiondisease phenotypeexperiencefunctional genomicsgastrointestinal systemhuman diseasein vivoin vivo imaginginsightinstrumentationlecturesmembermicrobiome researchmouse modelpatient populationpre-clinicalpre-clinical researchpreclinical studyprogramsprospectiverecruitrepositoryresearch facultysample fixationskillssuccesstissue preparationveterinary science
项目摘要
Summary
The Preclinical Models Core in the San Diego Digestive Diseases Research Center will provide access
to animal models of gastrointestinal and liver disease for preclinical studies and will assist in characterizing
disease activity prospectively and retrospectively in a comprehensive and uniform manner. The Core
emanated out of core services provided by a past NIDDK-funded (R24) Mini-Center at the University of
California, San Diego (UCSD). The approach to create the Preclinical Models Core is based on information
from surveys of Center member needs, experience with the prior Mini-Center at UCSD, the broad expertise of
Center members in digestive diseases research, and the insights of several of the Center members who have
served as advisors or in leadership roles for other Silvio O. Conte Centers. The Core will provide resources in
veterinary sciences and a technical infrastructure that enables animals to be studied comprehensively. The
services will include consultation on the selection and interpretation of animal models of digestive diseases,
ante-mortem imaging and post-mortem examination, including the development and interpretation of scoring
systems by veterinarians trained in comparative pathology. Thus, the Core will truly be “preclinical” in that it will
be modeling and evaluating disease with instrumentation also used in patients with the added advantage of the
controlled manipulations that are possible in these models. The Core will be led by two experienced leaders
with strong track records in applying animal models to basic and preclinical questions: Dr. Peter Ernst, a PhD
veterinarian with extensive experience in managing Core facilities, will be the Core Director and focus on
murine models of gastrointestinal disease and in vivo imaging. As the Core Co-Director, Dr. Tatiana Kisseleva
will provide her extensive experience with animal models of liver disease. Furthermore, the Core will interact
with and directly complement the Human Translational and Microbiomics and Functional Genomics Cores by
being able to relate the imaging results, biomarkers and clinical data to specific outcomes in animal models
and human disease. Thus, the Preclinical Models Core will benefit the investigators in the Center by providing
reliable, cost-effective services that are coordinated with the investigators’ research and other Cores to
facilitate and advance research related to the gastrointestinal tract and liver.
总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Tatiana Kisseleva其他文献
Tatiana Kisseleva的其他文献
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{{ truncateString('Tatiana Kisseleva', 18)}}的其他基金
The role of IL-17 signaling in alcohol-induced HCC
IL-17 信号在酒精诱导的 HCC 中的作用
- 批准号:
10299157 - 财政年份:2021
- 资助金额:
$ 26.43万 - 项目类别:
The role of IL-17 signaling in alcohol-induced HCC
IL-17 信号在酒精诱导的 HCC 中的作用
- 批准号:
10463697 - 财政年份:2021
- 资助金额:
$ 26.43万 - 项目类别:
Novel IL-23 inhibitor for the treatment of alcohol associated liver disease
用于治疗酒精相关性肝病的新型 IL-23 抑制剂
- 批准号:
10482350 - 财政年份:2020
- 资助金额:
$ 26.43万 - 项目类别:
Novel IL-23 inhibitor for the treatment of alcohol associated liver disease
用于治疗酒精相关性肝病的新型 IL-23 抑制剂
- 批准号:
10266186 - 财政年份:2020
- 资助金额:
$ 26.43万 - 项目类别:
The Role of Portal Fibroblasts in Cholestatic Liver Fibrosis
门静脉成纤维细胞在胆汁淤积性肝纤维化中的作用
- 批准号:
10441586 - 财政年份:2014
- 资助金额:
$ 26.43万 - 项目类别:
Inactivation of Hepatic Stellate Cells During Reversal of Liver Fibrosis
肝纤维化逆转过程中肝星状细胞失活
- 批准号:
8694267 - 财政年份:2014
- 资助金额:
$ 26.43万 - 项目类别:
The Role of Portal Fibroblasts in Cholestatic Liver Fibrosis
门静脉成纤维细胞在胆汁淤积性肝纤维化中的作用
- 批准号:
10312314 - 财政年份:2014
- 资助金额:
$ 26.43万 - 项目类别:
Epigenetics of human Hepatic Stellate Cells (HSCs) in NASH
NASH 中人肝星状细胞 (HSC) 的表观遗传学
- 批准号:
10367096 - 财政年份:2014
- 资助金额:
$ 26.43万 - 项目类别:
Inactivation of Hepatic Stellate Cells During Reversal of Liver Fibrosis
肝纤维化逆转过程中肝星状细胞失活
- 批准号:
9271180 - 财政年份:2014
- 资助金额:
$ 26.43万 - 项目类别:
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