Preclinical Models Core

临床前模型核心

• 批准号: 10617220
• 负责人: Tatiana Kisseleva
• 金额: $ 26.43万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617220
• 关键词: Animal Experimentation; Animal Model; Animals; Area; Autopsy; Biological Assay; Biological Markers; California; Clinical Data; Clinical Pathology; Comparative Pathology; Complement; Consult; Consultations; Core Facility; Data Analyses; Development; Digestive System Disorders; Disease; Doctor of Philosophy; Experimental Designs; Funding; Gastrointestinal Diseases; Gastrointestinal tract structure; Gene Expression; Genetic Predisposition to Disease; Health; Histology; Histopathology; Human; Image; Imaging Techniques; Infection; Inflammation; Infrastructure; Leadership; Liver; Liver diseases; Medicine; Methods; Microscopy; Mission; Modeling; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Outcome; Pathology; Patients; Pre-Clinical Model; R24; Records; Research; Research Personnel; Resources; Role; Scientist; Services; Stains; Surveys; System; Techniques; Training; Translating; Universities; Veterinarians; animal imaging; comparative; cost effective; data acquisition; disease phenotype; experience; functional genomics; gastrointestinal system; human disease; in vivo; in vivo imaging; insight; instrumentation; lectures; member; microbiome research; mouse model; patient population; pre-clinical; pre-clinical research; preclinical study; programs; prospective; recruit; repository; research faculty; sample fixation; skills; success; tissue preparation; veterinary science

Summary The Preclinical Models Core in the San Diego Digestive Diseases Research Center will provide access to animal models of gastrointestinal and liver disease for preclinical studies and will assist in characterizing disease activity prospectively and retrospectively in a comprehensive and uniform manner. The Core emanated out of core services provided by a past NIDDK-funded (R24) Mini-Center at the University of California, San Diego (UCSD). The approach to create the Preclinical Models Core is based on information from surveys of Center member needs, experience with the prior Mini-Center at UCSD, the broad expertise of Center members in digestive diseases research, and the insights of several of the Center members who have served as advisors or in leadership roles for other Silvio O. Conte Centers. The Core will provide resources in veterinary sciences and a technical infrastructure that enables animals to be studied comprehensively. The services will include consultation on the selection and interpretation of animal models of digestive diseases, ante-mortem imaging and post-mortem examination, including the development and interpretation of scoring systems by veterinarians trained in comparative pathology. Thus, the Core will truly be “preclinical” in that it will be modeling and evaluating disease with instrumentation also used in patients with the added advantage of the controlled manipulations that are possible in these models. The Core will be led by two experienced leaders with strong track records in applying animal models to basic and preclinical questions: Dr. Peter Ernst, a PhD veterinarian with extensive experience in managing Core facilities, will be the Core Director and focus on murine models of gastrointestinal disease and in vivo imaging. As the Core Co-Director, Dr. Tatiana Kisseleva will provide her extensive experience with animal models of liver disease. Furthermore, the Core will interact with and directly complement the Human Translational and Microbiomics and Functional Genomics Cores by being able to relate the imaging results, biomarkers and clinical data to specific outcomes in animal models and human disease. Thus, the Preclinical Models Core will benefit the investigators in the Center by providing reliable, cost-effective services that are coordinated with the investigators’ research and other Cores to facilitate and advance research related to the gastrointestinal tract and liver.

概括 圣地亚哥消化疾病研究中心的临床前模型核心将提供访问权限 用于胃肠道和肝脏疾病的动物模型进行临床前研究，并将有助于表征 以全面、统一的方式前瞻性和回顾性地预测疾病活动。核心 源于过去 NIDDK 资助的 (R24) 大学迷你中心提供的核心服务 加利福尼亚州圣地亚哥 (UCSD)。创建临床前模型核心的方法基于信息 根据对中心成员需求的调查、加州大学圣地亚哥分校先前迷你中心的经验、 中心成员在消化系统疾病方面的研究，以及几位中心成员的见解 曾担任其他 Silvio O. Conte 中心的顾问或领导职务。核心将提供资源 兽医科学和技术基础设施，使动物能够得到全面的研究。这 服务将包括消化系统疾病动物模型的选择和解释咨询， 死前成像和死后检查，包括评分的制定和解释 由接受过比较病理学培训的兽医建立的系统。因此，核心将真正成为“临床前”，因为它将 可以使用也用于患者的仪器来建模和评估疾病，并具有以下额外优势 这些模型中可能进行的受控操作。核心将由两位经验丰富的领导者领导 在将动物模型应用于基本和临床前问题方面拥有良好的记录：Peter Ernst 博士，博士 在管理核心设施方面拥有丰富经验的兽医将担任核心总监，并专注于 胃肠道疾病和体内成像的小鼠模型。作为核心联合主任，Tatiana Kisseleva 博士 将为她提供肝病动物模型方面的丰富经验。此外，核心将互动 并直接补充人类翻译、微生物组学和功能基因组学核心 能够将成像结果、生物标志物和临床数据与动物模型中的特定结果联系起来 和人类疾病。因此，临床前模型核心将通过提供使中心的研究人员受益 可靠、具有成本效益的服务，与研究人员的研究和其他核心相协调，以 促进和推进与胃肠道和肝脏相关的研究。