Effect of Hypercapnia Treatment on Respiratory Recovery after Spinal Cord Injury
高碳酸血症治疗对脊髓损伤后呼吸恢复的影响
基本信息
- 批准号:10589975
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdherenceAffectAlveolarAnimalsBreathingCarbon DioxideCardiovascular systemCaringCause of DeathCervicalCervical spinal cord injuryChemical StimulationChronicClinicalClinical TrialsCognitionDiseaseDropoutEducational InterventionEnrollmentExerciseFeasibility StudiesFutureGeneral PopulationHealthHeart DiseasesHigh PrevalenceHumanHypercapniaHypertensionHypoxiaImpairmentIndividualInjuryInnovative TherapyInstitutional Review BoardsIntegrated Health Care SystemsInterventionKnowledgeLifeLinkMeasuresMechanicsMinority GroupsMissionMorbidity - disease rateMotorMultiple SclerosisMuscleNerveNeuromuscular DiseasesOutcomeParesisPatientsPersonal SatisfactionPersonsPilot ProjectsPlacebosPolysomnographyPopulationQuality of lifeRecoveryReportingResearchResearch Project GrantsResourcesRespiration DisordersRespiratory DiaphragmRespiratory MusclesRespiratory ParalysisRespiratory Signs and SymptomsRespiratory physiologyRoleSample SizeSeveritiesSleepSleep Apnea SyndromesSleep DisordersSocial FunctioningSpinal cord injurySpinal cord injury patientsStrokeStructureSymptomsTechniquesTestingTherapeutic InterventionThoracic InjuriesTissuesTrainingUnited StatesVentilatorVeteransWakefulnessWithdrawalacceptability and feasibilityarmbasecardiovascular effectsexercise rehabilitationfeasibility testingfollow-upfunctional improvementimprovedimprovement on sleepinnovationinterestmechanical devicemortalitymotor recoverymuscle strengthnovelnovel strategiesnovel therapeutic interventionnovel therapeuticspressurepreventprogramspsychologicrandomized controlled designrecruitrespiratoryventilation
项目摘要
Project Summary Abstract
Title: Effect of Hypercapnia Treatment on Respiratory Recovery after Spinal Cord
Injury.
Respiratory and cardiovascular complications are the most common causes of death in
the first year post-injury. Nearly 80% of patients with SCI, including Veterans, suffer from
breathing and sleep disorders after six months of injury. However, most patients with
SCI do not tolerate standard mechanical treatment leading to a lack of adherence.
Therefore, identifying other therapies is important for this common condition linked to
poor outcomes in the general population (heart disease, stroke, hypertension, and poor
cognition). In individuals with SCI, it has been reported that chemical stimulation using
acute intermittent hypoxia techniques improves ventilatory and motor recovery. The
effect of intermittent hypoxia is dependent on the level of alveolar Carbon Dioxide (CO2)
and may pose undesirable cardiovascular effects. However, the effect of hypercapnia
alone on respiratory recovery during wakefulness and sleep in patients with SCI is
unknown.
The purpose of this application is to identify new therapeutic interventions for respiratory
and sleep disorders in Veterans with SCI. This application proposes a pilot study to
enroll 30 Veterans with SCI to receive two weeks of daily acute intermittent hypercapnia
(dAIHc) treatment. There will be three specific aims to address the following hypotheses:
Specific Aim (1): Measure the recruitment rate and feasibility of a pilot intervention
using dAIHc in individuals with SCI.
Specific Aim (2): Test the hypothesis that dAIHc will increase minute ventilation and
respiratory muscle forces in individuals with SCI.
Specific Aim (3): Test the hypothesis that dAIHc will improve sleep parameters in
individuals with SCI.
项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Abdulghani Sankari其他文献
Abdulghani Sankari的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Abdulghani Sankari', 18)}}的其他基金
Novel treatment of sleep apnea by upper airway and respiratory muscle training
通过上呼吸道和呼吸肌训练治疗睡眠呼吸暂停的新方法
- 批准号:
10326330 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Pathogenesis of Sleep Disordered Breathing in Spinal Cord Injury Patients
脊髓损伤患者睡眠呼吸障碍的发病机制
- 批准号:
9794746 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Pathogenesis of Sleep Disordered Breathing in Spinal Cord Injury Patients
脊髓损伤患者睡眠呼吸障碍的发病机制
- 批准号:
8666539 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Pathogenesis of Sleep Disordered Breathing in Spinal Cord Injury Patients
脊髓损伤患者睡眠呼吸障碍的发病机制
- 批准号:
8442112 - 财政年份:2013
- 资助金额:
-- - 项目类别:
相似海外基金
Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
- 批准号:
10594350 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Evaluating Centralizing Interventions to Address Low Adherence to Lung Cancer Screening Follow-up in Decentralized Settings
评估集中干预措施,以解决分散环境中肺癌筛查随访依从性低的问题
- 批准号:
10738120 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
- 批准号:
10526768 - 财政年份:2022
- 资助金额:
-- - 项目类别:
Suubi-Mhealth: A mobile health intervention to address depression and improve ART adherence among Youth living with HIV (YLHIV) in Uganda
Suubi-Mhealth:一种移动健康干预措施,旨在解决乌干达艾滋病毒感染者 (YLHIV) 青少年的抑郁症问题并提高抗逆转录病毒疗法的依从性
- 批准号:
10701072 - 财政年份:2022
- 资助金额:
-- - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10679092 - 财政年份:2021
- 资助金额:
-- - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10432133 - 财政年份:2021
- 资助金额:
-- - 项目类别:
A behavioral intervention for Black men who have sex with men and live with HIV to address intersectional stigma and improve antiretroviral therapy adherence
针对男男性行为且感染艾滋病毒的黑人男性进行行为干预,以解决交叉耻辱并提高抗逆转录病毒治疗的依从性
- 批准号:
10327065 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
- 批准号:
10377366 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Leveraging Technology to Address Access and Adherence to Conventional Hospital-Based Pulmonary Rehabilitation in Veterans with COPD
利用技术解决慢性阻塞性肺病退伍军人接受和坚持传统医院肺康复的问题
- 批准号:
10574496 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
- 批准号:
9403567 - 财政年份:2017
- 资助金额:
-- - 项目类别: