Effect of Hypercapnia Treatment on Respiratory Recovery after Spinal Cord Injury

高碳酸血症治疗对脊髓损伤后呼吸恢复的影响

• 批准号: 10589975
• 负责人: Abdulghani Sankari
• 金额: --
• 依托单位: JOHN D DINGELL VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10589975
• 关键词: Acute; Address; Adherence; Affect; Alveolar; Animals; Breathing; Carbon Dioxide; Cardiovascular system; Caring; Cause of Death; Cervical; Cervical spinal cord injury; Chemical Stimulation; Chronic; Clinical; Clinical Trials; Cognition; Disease; Dropout; Educational Intervention; Enrollment; Exercise; Feasibility Studies; Future; General Population; Health; Heart Diseases; High Prevalence; Human; Hypercapnia; Hypertension; Hypoxia; Impairment; Individual; Injury; Innovative Therapy; Institutional Review Boards; Integrated Health Care Systems; Intervention; Knowledge; Life; Link; Measures; Mechanics; Minority Groups; Mission; Morbidity - disease rate; Motor; Multiple Sclerosis; Muscle; Nerve; Neuromuscular Diseases; Outcome; Paresis; Patients; Personal Satisfaction; Persons; Pilot Projects; Placebos; Polysomnography; Population; Quality of life; Recovery; Reporting; Research; Research Project Grants; Resources; Respiration Disorders; Respiratory Diaphragm; Respiratory Muscles; Respiratory Paralysis; Respiratory Signs and Symptoms; Respiratory physiology; Role; Sample Size; Severities; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Social Functioning; Spinal cord injury; Spinal cord injury patients; Stroke; Structure; Symptoms; Techniques; Testing; Therapeutic Intervention; Thoracic Injuries; Tissues; Training; United States; Ventilator; Veterans; Wakefulness; Withdrawal; acceptability and feasibility; arm; base; cardiovascular effects; exercise rehabilitation; feasibility testing; follow-up; functional improvement; improved; improvement on sleep; innovation; interest; mechanical device; mortality; motor recovery; muscle strength; novel; novel strategies; novel therapeutic intervention; novel therapeutics; pressure; prevent; programs; psychologic; randomized controlled design; recruit; respiratory; ventilation

Project Summary Abstract Title: Effect of Hypercapnia Treatment on Respiratory Recovery after Spinal Cord Injury. Respiratory and cardiovascular complications are the most common causes of death in the first year post-injury. Nearly 80% of patients with SCI, including Veterans, suffer from breathing and sleep disorders after six months of injury. However, most patients with SCI do not tolerate standard mechanical treatment leading to a lack of adherence. Therefore, identifying other therapies is important for this common condition linked to poor outcomes in the general population (heart disease, stroke, hypertension, and poor cognition). In individuals with SCI, it has been reported that chemical stimulation using acute intermittent hypoxia techniques improves ventilatory and motor recovery. The effect of intermittent hypoxia is dependent on the level of alveolar Carbon Dioxide (CO2) and may pose undesirable cardiovascular effects. However, the effect of hypercapnia alone on respiratory recovery during wakefulness and sleep in patients with SCI is unknown. The purpose of this application is to identify new therapeutic interventions for respiratory and sleep disorders in Veterans with SCI. This application proposes a pilot study to enroll 30 Veterans with SCI to receive two weeks of daily acute intermittent hypercapnia (dAIHc) treatment. There will be three specific aims to address the following hypotheses: Specific Aim (1): Measure the recruitment rate and feasibility of a pilot intervention using dAIHc in individuals with SCI. Specific Aim (2): Test the hypothesis that dAIHc will increase minute ventilation and respiratory muscle forces in individuals with SCI. Specific Aim (3): Test the hypothesis that dAIHc will improve sleep parameters in individuals with SCI.

项目摘要