Y-SPAN: Yale Translational Cerebroprotection Program in SPAN

Y-SPAN：耶鲁大学 SPAN 转化性脑保护计划

• 批准号: 10590809
• 负责人: LAUREN H SANSING
• 金额: $ 66.95万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590809
• 关键词: Acute; Adherence; Aging; Animal Testing; Animals; Brain Ischemia; Caring; Cell Death; Cerebral Edema; Clinical; Clinical Research; Clinical Trials; Collaborations; Communication; Data Analyses; Data Collection; Dedications; Diabetes Mellitus; Disease; Doctor of Philosophy; Ensure; Event; Failure; Feedback; Filament; Future; Goals; Health; Hypertension; Injury; Intervention; Ischemia; Ischemic Stroke; Laboratories; Leukocytes; MRI Scans; Magnetic Resonance Imaging; Measures; Metabolic syndrome; Methodology; Methods; Microglia; Middle Cerebral Artery Occlusion; Modeling; National Institute of Neurological Disorders and Stroke; Nervous System Trauma; Obesity; Operative Surgical Procedures; Outcome; Outcome Assessment; Pathway interactions; Patients; Perfusion; Physicians; Pneumonia; Predictive Value; Protocols documentation; Randomized; Reperfusion Therapy; Research Design; Research Personnel; Rodent; Rodent Model; Schedule; Scientist; Site; Specialist; Stroke; Structure; Testing; Therapeutic Intervention; Thrombectomy; Tissues; Training; Translating; Translations; Work; behavioral outcome; biomedical imaging; candidate identification; cerebroprotection; comorbidity; disability; efficacy testing; excitotoxicity; improved; improved outcome; innovation; mortality; neurobehavioral; next generation; novel; oxidative damage; post stroke; pre-clinical; pre-clinical assessment; pre-clinical research; programs; recruit; skills; stroke model; stroke patient; stroke therapy; targeted treatment; therapeutic candidate; therapeutic evaluation; thromboinflammation; timeline; translational scientist; translational study

Project Summary. The project proposes a rodent preclinical stroke therapeutics testing site at Yale for the NINDS program Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Cerebroprotection. A team of investigators including basic scientists studying mechanisms of injury after stroke, translational researchers, biomedical imaging specialists, and clinical trialists form a highly collaborative and interactive team dedicated to testing candidate cerebroprotectants selected by NINDS under the oversight of a national coordinating center. The overall goal is to identify the most promising candidates for novel stroke therapies to then be tested in clinical trials, advancing the care for stroke patients. In Aim 1 of the project we will establish the SPAN standard operating protocols and timeline for testing of the interventions. In Aim 2, we will test the efficacy of candidate cerebroprotectants in multiple rodent models of transient middle cerebral artery occlusion, including models incorporating aging and comorbidities. In an exploratory Aim 3, we will test innovative methods to improve the predictive value of the SPAN testing protocols to identify candidate treatments that will be efficacious in patients and enhance the impact of SPAN.

项目摘要。 该项目建议在耶鲁大学为NINDS项目建立一个啮齿动物临床前中风治疗试验基地 中风临床前评估网络（SPAN）支持急性脑保护的转化研究。 一组包括基础科学家在内的研究人员研究了中风后的损伤机制， 研究人员、生物医学成像专家和临床试验人员形成了一个高度协作和互动的 一个专门负责测试NINDS在国家监督下选择的候选杀虫剂的小组 协调中心。总的目标是确定最有前途的候选人为新的中风疗法 然后在临床试验中进行测试，推进对中风患者的护理。 在项目目标1中，我们将建立SPAN标准操作方案和时间轴，用于测试 干预措施。在目标2中，我们将在多种啮齿类动物模型中测试候选抗肿瘤保护剂的功效。 短暂性大脑中动脉闭塞，包括老化和合并症模型。中 探索性目标3，我们将测试创新方法，以提高SPAN测试的预测价值 方案，以确定候选治疗，将是有效的患者，并提高SPAN的影响。