Training Program in Basic and Translational Pediatric Oncology Research

基础和转化儿科肿瘤学研究培训计划

• 批准号: 10590705
• 负责人: TIMOTHY P CRIPE
• 金额: $ 39.34万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10590705
• 关键词: Pediatric Oncology; Research; Training Programs

PROJECT SUMMARY Pediatric cancers are generally quite different than adult cancers. For example, pediatric cancers exhibit unique oncogenic mechanisms, often reflective of aberrant developmental pathways. Thankfully, pediatric cancers are rare, and so the field must rely more strongly on cooperation, collaboration, and team-science to enable scientific progress and translation to the clinic. These realities, when combined with an insufficient research workforce, necessitate the development of a specifically-designed training program for pediatric oncology research. The overarching goal of the “Training Program in Basic and Translational Pediatric Oncology Research” is to provide postdoctoral and graduate student trainees with the requisite skills and expertise to develop into successful researchers focused on pediatric oncology. The Training Program is centered at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, a world-renowned pediatric research hospital environment, and also leverages the strengths of The Ohio State University as an academic partner. Training includes strong mentorship in laboratory-based basic and translational research with newly-developed program-specific classwork, a broad palette of elective classwork, thoughtful training in career-development, team science, and relationship-building, and a clinical exposure plan to enable trainees to better appreciate the impact of their work on patients, families, and clinical teams. This new application seeks 6 training slots per year: 3 postdoctoral fellows and 3 graduate students. Trainees will generally spend 2 years in the Training Program. Postdoctoral trainees include Pediatric Heme/Onc/BMT MD (or MD/PhD) fellows and PhD (or MD/PhD) postdoctoral trainees. Graduate students are drawn from one of three graduate programs at The Ohio State University. A well-constructed trainee selection plan with a focus on diversity will ensure that the trainees who enter the Training Program have a high-likelihood for success in their ultimate entry into the field of pediatric cancer research. Finally, the Training Program includes a thoughtful logic model as a framework for program evaluation and continuous improvement cycles. The trainees, the mentors, and the Training Program itself will all be subjected to rigorous evaluation by our External and Internal Advisory Boards, consisting of individuals with key areas of expertise and focus, to ensure that the Training Program continues to evolve as training needs evolve. Overall, the Training Program in Basic and Translational Pediatric Oncology Research will expand highly- skilled pediatric oncology research and improve its collaborative potential to transform the care of children with cancer.

项目摘要 儿童癌症通常与成人癌症有很大不同。例如，儿科癌症表现出独特的 致癌机制，通常反映异常的发育途径。幸运的是，儿科癌症 罕见，因此该领域必须更加依赖合作，协作和团队科学，以使科学 进展和翻译到诊所。这些现实，再加上研究人员不足， 有必要为儿科肿瘤学研究制定专门设计的培训计划。 “基础和转化儿科肿瘤学研究培训计划”的总体目标是 为博士后和研究生学员提供必要的技能和专业知识，以发展成为 成功的研究人员专注于儿科肿瘤学。该培训计划是集中在阿比盖尔韦克斯纳 全国儿童医院研究所，一个世界知名的儿科研究医院环境， 并利用俄亥俄州州立大学的优势作为学术合作伙伴。培训内容包括： 导师在实验室为基础的基础和转化研究与新开发的具体方案 课堂作业，选修课的广泛调色板，在职业发展，团队科学周到的培训， 建立关系，以及临床接触计划，使学员能够更好地了解他们工作的影响 病人家属和临床团队 这个新的申请每年寻求6个培训名额：3名博士后研究员和3名研究生。学员 一般会在培训计划中花费2年时间。博士后培训人员包括儿科血红素/Onc/BMT MD（或MD/PhD）研究员和PhD（或MD/PhD）博士后学员。研究生是从一个 俄亥俄州州立大学的三个研究生项目。一个精心设计的培训生选拔计划， 多样性将确保参加培训计划的学员在以下方面取得成功的可能性很高： 他们最终进入了儿科癌症研究领域。 最后，培训计划包括一个深思熟虑的逻辑模型，作为计划评估的框架， 持续改进周期。学员、导师和培训计划本身都将受到 由我们的外部和内部咨询委员会进行严格的评估，该委员会由具有以下关键领域的个人组成： 专业知识和重点，以确保培训计划随着培训需求的发展而不断发展。 总体而言，基础和转化儿科肿瘤学研究的培训计划将高度扩展- 熟练的儿科肿瘤学研究，并提高其合作潜力，以改变儿童的护理， 癌

项目成果

The DBD-α4 helix of EWS::FLI is required for GGAA microsatellite binding that underlies genome regulation in Ewing sarcoma.

EWS::FLI 的 DBD-α4 螺旋是 GGAA 微卫星结合所必需的，是尤文肉瘤基因组调控的基础。

• DOI: 10.1101/2024.01.31.578127
• 发表时间: 2024
• 期刊: bioRxiv : the preprint server for biology
• 作者: Bayanjargal,Ariunaa;Taslim,Cenny;Showpnil,IftekharA;Selich-Anderson,Julia;Crow,JesseC;Lessnick,StephenL;Theisen,EmilyR
• 通讯作者: Theisen,EmilyR