Altered Oscillatory Dynamics in People with HIV and Methamphetamine Use Disorder
艾滋病毒和甲基苯丙胺使用障碍患者的振荡动力学改变
基本信息
- 批准号:10590607
- 负责人:
- 金额:$ 1.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-09 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:AccelerationAddressAdherenceAdultAreaAttentionBehaviorBehavioralBrainBrain MappingBrain regionCD4 Positive T LymphocytesCell CountClinicalCognitionCognitiveCognitive deficitsComplexContractsDecision MakingDisease ProgressionDorsalDropoutExhibitsFellowshipFunctional disorderGeneral PopulationGoalsHIVHIV InfectionsHIV-associated cognitive impairmentHIV/AIDSHumanImpaired cognitionIndividualInternationalLibidoLife ExpectancyLiteratureMagnetoencephalographyManuscriptsMapsMentorsMethamphetamineMethamphetamine use disorderModelingNational Institute of Drug AbuseNeedle SharingNeurologicNeurophysiology - biologic functionNeurosciencesOutcomePaperParticipantPeer ReviewPerformancePersonsPlayPostbaccalaureateProcessPublic HealthResearchRiskRoleScienceScientistStimulusSubstance Use DisorderSystemTimeTrainingUnited StatesUnsafe SexViralVirus ReplicationVisual attentionWorkaddictionantiretroviral therapyattentional controlblood-brain barrier disruptionbrain dysfunctioncognitive controlcognitive functioncognitive neurosciencecomorbidityconflict resolutioncravingdoctoral studentexperienceimaging modalityimmune activationinnovationinterestmedication compliancemethamphetamine effectmethamphetamine usemillisecondneuralneuroAIDSneuroimagingprematureresponsesexual risk takingstimulus processingsubstance usesustained attentiontemporal measurementvigilance
项目摘要
Project Summary/Abstract
Virally suppressed people with HIV (PWH) now have a life expectancy near that of the general population, yet
their risk of developing cognitive impairment remains substantially elevated relative to seronegative individuals.
Methamphetamine use disorder (METH) is another condition that is significantly more prevalent in PWH, and
METH is also associated with cognitive impairment. Specifically, both HIV and METH appear to have a negative
impact on the processes associated with attention and cognitive control, including decision-making, sustained
attention, and inhibiting task irrelevant stimuli. Human neuroimaging studies in this area have shown that both
PWH and people with METH exhibit inefficient neural processing within the brain networks serving attention and
cognitive control (e.g., frontoparietal, salience). However, there is a dearth of extant literature, specifically with
regard to the synergistic effects of HIV and METH on cognitive and brain dysfunction. Identifying the overall
impact of HIV and METH is critical, as aberrations in attention and cognitive control networks have been shown
to have negative downstream effects on clinical outcomes, including poorer medication adherence in PWH, more
intense methamphetamine cravings, and maladaptive decision-making.
The National Institute on Drug Abuse (NIDA) recently issued a Notice of Special Interest (NOT-DA-21-030) citing
that PWH and a comorbid substance use disorder such as METH “often have exacerbated or accelerated …
cognitive/behavior deficits” relative to nonusers, and that “approaches that involve whole brain modeling or
consideration of complex systems are likely to illuminate brain network-level mechanisms underlying [these]
clinical deficits.” The proposed fellowship application would provide advanced training in this area and initiate a
project that directly addresses this call through a dynamic neuroimaging study that leverages recent discoveries
to identify the synergistic effects of METH and HIV on the brain regions and networks that serve attention and
cognitive control dysfunction in virally suppressed PWH with and without METH and matched seronegative
controls (i.e., four groups). Aim 1 will quantify the adverse synergistic impact of METH in PWH on performance
and the neural oscillatory dynamics serving attention and cognitive control, while Aim 2 will determine whether
METH accentuates the abnormally elevated spontaneous cortical activity observed in virally suppressed PWH
compared to demographically matched seronegative controls. The applicant is a promising second-year PhD
student studying neuroscience who has already distinguished herself through a first-authored manuscript directly
related to the proposed work, two first-authored manuscripts under peer review, and a high number of coauthored
papers through extensive postbaccalaureate research experience. In the proposed fellowship, she will be
mentored by Dr. Tony Wilson – an internationally known expert in human neuroimaging, HIV, and substance
use – and she will receive advanced training in addiction science, neuroHIV, and clinical cognitive neuroscience.
项目总结/摘要
病毒抑制的艾滋病毒感染者(PWH)现在的预期寿命接近普通人群,但
相对于血清反应阴性的个体,他们发展认知障碍的风险仍然显著升高。
甲基苯丙胺使用障碍(METH)是另一种在PWH中更为普遍的疾病,
甲基苯丙胺还与认知障碍有关。具体来说,艾滋病毒和甲基似乎有一个阴性
对与注意力和认知控制相关的过程的影响,包括决策,持续
注意力和抑制任务无关的刺激。在这一领域的人类神经成像研究表明,
PWH和METH患者在大脑网络中表现出低效的神经处理,
认知控制(例如,额顶叶,显著性)。然而,现存的文献很少,特别是
关于HIV和METH对认知和脑功能障碍的协同作用。确定总体
艾滋病毒和甲基苯丙胺的影响是至关重要的,因为注意力和认知控制网络已经显示出失常
对临床结果有负面的下游影响,包括威尔斯亲王医院的药物依从性较差,
对冰毒的强烈渴望以及不适应的决策
国家药物滥用研究所(NIDA)最近发布了一份特别关注的通知(NOT-DA-21-030),
PWH和一种共病的物质使用障碍,如METH“通常会加剧或加速......
认知/行为缺陷”相对于非用户,“方法涉及全脑建模或
对复杂系统的考虑可能会阐明[这些]背后的大脑网络水平机制
临床缺陷”拟议的研究金申请将提供这一领域的高级培训,并启动一个
该项目通过动态神经成像研究直接解决了这一问题,该研究利用了最近的发现
确定METH和HIV对大脑区域和网络的协同作用,
伴或不伴METH的病毒抑制性PWH患者的认知控制功能障碍以及匹配的血清阴性
对照(即,四组)。目标1将量化PWH中METH对性能的不利协同影响
和神经振荡动力学服务于注意力和认知控制,而目标2将决定是否
METH加重了在病毒抑制PWH中观察到的异常升高的自发性皮质活动
与人口统计学匹配的血清阴性对照组相比。申请人是一个很有前途的二年级博士
一个学习神经科学的学生,她已经通过第一作者的手稿直接脱颖而出
与拟议的工作有关,两篇第一作者的手稿正在接受同行评审,还有大量的合著者,
论文通过广泛的postbaccalaureate研究经验。在拟议的奖学金,她将是
由Tony Wilson博士指导-他是国际知名的人类神经成像,HIV和物质专家
她将接受成瘾科学、神经艾滋病毒和临床认知神经科学方面的高级培训。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mikki Schantell其他文献
Mikki Schantell的其他文献
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{{ truncateString('Mikki Schantell', 18)}}的其他基金
Methamphetamine and HIV status modulate the neural dynamics underlying executive dysfunction and emotion dysregulation
甲基苯丙胺和艾滋病毒状态调节执行功能障碍和情绪失调的神经动力学
- 批准号:
10762904 - 财政年份:2023
- 资助金额:
$ 1.71万 - 项目类别:
Altered Oscillatory Dynamics in People with HIV and Methamphetamine Use Disorder
艾滋病毒和甲基苯丙胺使用障碍患者的振荡动力学改变
- 批准号:
10484756 - 财政年份:2022
- 资助金额:
$ 1.71万 - 项目类别:
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