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Developmental Core

发展核心

基本信息

批准号：
10598939
负责人：
Elizabeth Chiao
金额：
$ 5.82万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10598939
关键词：
AIDS related cancer Address Advanced Development Area Award Behavioral Behavioral Sciences Biomedical Engineering Brazil Cancer Center Categories Cervical Cancer Screening Cervical dysplasia Clinical Clinical Research Collaborations Communities Country Data Analyses Development Diagnosis Discipline Discipline of obstetrics Education Eligibility Determination Epidemiology Ethics Faculty Feedback Fellowship Fostering Funding Goals Grant Gynecologic Oncology Gynecologic Pathology Gynecology HIV HIV Infections HIV/AIDS Hospitals Hour Image Image Analysis Infrastructure Institution Laboratories Laboratory Research Language Life Low income Machine Learning Malignant Neoplasms Malignant neoplasm of cervix uteri Medicine Mentors Mentorship Methods Mozambique Oncology Participant Pathology Persons Physicians Pilot Projects Portuguese Prevention Prevention approach Research Research Design Research Infrastructure Research Personnel Research Project Grants Research Training Residencies Resource Sharing Rice Risk Risk Factors Scientist Technology Texas Time Training Translational Research United States National Institutes of Health Universities Vision Woman Writing cancer therapy career career development cervical cancer prevention clinical care co-infection college comorbidity cost experience flexibility human subject protection implementation science improved innovation interest lectures low and middle-income countries member multidisciplinary novel programs recruit research study skills survivorship training opportunity videoconference virtual

项目摘要

ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Brazil and Mozambique. The research theme chosen for this U54 HIV-Associated Malignancy Research Center (HAMRC) is to develop novel, low-cost and technologically feasible approaches for cervical cancer screening, diagnosis, and treatment in women living with HIV (WLWH) in low- and middle-income countries (LMICs). This HAMRC will be a collaboration between institutions in the US, Mozambique and Brazil and includes investigators with expertise in HIV/AIDS, Cervical Cancer, Bioengineering, Pathology, Epidemiology and Behavioral Science. The investigators have several ongoing scientific and clinical collaborations which include projects across all three countries. Our proposal addresses the NIH priority: To address HIV-associated comorbidities, coinfections and complications, which includes Malignancies as a category. HIV infection is a known risk factor for cervical cancer, with WLWH having an approximate 6-fold increased risk of developing cervical cancer. The overall goals of the AVANÇO Research Consortium include: 1) Establish sustainable research infrastructure to perform multi-institutional research studies related to HIV-associated malignancies across institutions in the US, Brazil and Mozambique. We will build a comprehensive research program focused on identifying novel, low-cost and technologically feasible approaches for the prevention, diagnosis, and treatment of cervical cancer in WLWH in LMICs. 2) Conduct two Research Projects that advance the development of promising low-cost technologies focused on the diagnoses of high-grade cervical dysplasia and invasive cervical cancer among WLWH. 3) Facilitate and enhance the professional development of junior investigators to conduct HIV- associated malignancy research in Mozambique and Brazil. Through our Developmental Core and Shared Resource Core, we will build research capacity and collaboration through formal research training courses, pilot project funding, and implementation of a Project ECHO® program for research capacity building focused on mentoring and supporting early-career investigators.

摘要