Project 1

摘要 Avan圣O研究联盟的总体愿景是建立可持续的基础设施 在巴西和巴西开发专注于艾滋病毒相关恶性肿瘤的研究项目 莫桑比克。本次U54 HIV相关恶性肿瘤研究选择的研究主题 中心(HAMRC)将开发新的、低成本和技术上可行的方法来 低收入和低收入地区艾滋病毒携带者(WLWH)的宫颈癌筛查、诊断和治疗 中等收入国家(LMIC)。这一HAMRC将是 美国、莫桑比克和巴西，包括在艾滋病毒/艾滋病、子宫颈疾病方面有专长的调查人员 癌症、生物工程、病理学、流行病学和行为科学。调查人员 有几个正在进行的科学和临床合作，其中包括所有三个项目 国家。 我们的提案解决了美国国立卫生研究院的优先事项：解决艾滋病毒相关的共病、合并感染 和并发症，其中包括恶性肿瘤作为一个类别。艾滋病毒感染是一个已知的危险因素。 对于宫颈癌，WLWH患宫颈癌的风险大约增加6倍 癌症。 Avan圣O研究联盟的总体目标包括： 1)建立可持续的研究基础设施，开展多机构研究 与美国、巴西和莫桑比克的机构中的艾滋病毒相关恶性肿瘤有关。我们 将建立一个全面的研究计划，专注于发现新颖、低成本和 预防、诊断和治疗宫颈病变的技术可行方法 LMICs中WLWH中的癌症。 2)开展两个研究项目，推动前景看好的低成本发展 侧重于高度宫颈不典型增生和侵袭性宫颈的诊断技术 WLWH中的癌症。 3)促进和加强初级调查人员的专业发展，以开展艾滋病毒-- 莫桑比克和巴西的相关恶性肿瘤研究。通过我们的发展核心 和共享资源核心，我们将通过正式的 研究培训课程、试点项目资金和项目ECHO®计划的实施 对于研究能力建设，重点是指导和支持职业生涯早期的调查人员。

ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Brazil and Mozambique. The research theme chosen for this U54 HIV-Associated Malignancy Research Center (HAMRC) is to develop novel, low-cost and technologically feasible approaches for cervical cancer screening, diagnosis, and treatment in women living with HIV (WLWH) in low- and middle-income countries (LMICs). This HAMRC will be a collaboration between institutions in the US, Mozambique and Brazil and includes investigators with expertise in HIV/AIDS, Cervical Cancer, Bioengineering, Pathology, Epidemiology and Behavioral Science. The investigators have several ongoing scientific and clinical collaborations which include projects across all three countries. Our proposal addresses the NIH priority: To address HIV-associated comorbidities, coinfections and complications, which includes Malignancies as a category. HIV infection is a known risk factor for cervical cancer, with WLWH having an approximate 6-fold increased risk of developing cervical cancer. The overall goals of the AVANÇO Research Consortium include: 1) Establish sustainable research infrastructure to perform multi-institutional research studies related to HIV-associated malignancies across institutions in the US, Brazil and Mozambique. We will build a comprehensive research program focused on identifying novel, low-cost and technologically feasible approaches for the prevention, diagnosis, and treatment of cervical cancer in WLWH in LMICs. 2) Conduct two Research Projects that advance the development of promising low-cost technologies focused on the diagnoses of high-grade cervical dysplasia and invasive cervical cancer among WLWH. 3) Facilitate and enhance the professional development of junior investigators to conduct HIV- associated malignancy research in Mozambique and Brazil. Through our Developmental Core and Shared Resource Core, we will build research capacity and collaboration through formal research training courses, pilot project funding, and implementation of a Project ECHO® program for research capacity building focused on mentoring and supporting early-career investigators.