Project 1

摘要 安凡尼欧研究联盟的总体愿景是建立可持续的基础设施 在巴西开展以艾滋病毒相关恶性肿瘤为重点的研究项目， 莫桑比克.本次U 54艾滋病相关研究选择的研究主题 该中心（HAMRC）的目标是开发新的，低成本和技术可行的方法， 在低收入和低收入妇女中进行宫颈癌筛查、诊断和治疗 中等收入国家（LMIC）。该人权高专办将是一个机构之间的合作， 美国、莫桑比克和巴西，包括具有艾滋病毒/艾滋病、宫颈癌和生殖器疾病方面专业知识的研究人员。 癌症、生物工程、病理学、流行病学和行为科学。调查人员 有几个正在进行的科学和临床合作，其中包括所有三个项目 国家 我们的提案涉及NIH的优先事项：解决HIV相关的合并症，合并感染 和并发症，其中包括恶性肿瘤作为一个类别。艾滋病毒感染是一个已知的风险因素 对于宫颈癌，WLWH的宫颈癌发生风险增加约6倍， 癌 AVANESTO研究联盟的总体目标包括： 1)建立可持续的研究基础设施，以进行多机构研究 在美国、巴西和莫桑比克的机构中，我们 将建立一个全面的研究计划，重点是确定新的，低成本的， 预防、诊断和治疗宫颈癌的技术可行方法 低收入国家的WLWH癌症。 2)开展两个研究项目，推动有前途的低成本 技术集中在高度宫颈发育不良和浸润性宫颈癌的诊断 WLWH中的癌症 3)促进和加强初级调查人员的专业发展， 在莫桑比克和巴西进行的相关恶性肿瘤研究。通过我们的发展核心 和共享资源核心，我们将建立研究能力和合作，通过正式的 研究培训课程，试点项目资金，以及ECHO®项目的实施 在研究能力建设方面，侧重于指导和支持早期职业调查人员。

ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Brazil and Mozambique. The research theme chosen for this U54 HIV-Associated Malignancy Research Center (HAMRC) is to develop novel, low-cost and technologically feasible approaches for cervical cancer screening, diagnosis, and treatment in women living with HIV (WLWH) in low- and middle-income countries (LMICs). This HAMRC will be a collaboration between institutions in the US, Mozambique and Brazil and includes investigators with expertise in HIV/AIDS, Cervical Cancer, Bioengineering, Pathology, Epidemiology and Behavioral Science. The investigators have several ongoing scientific and clinical collaborations which include projects across all three countries. Our proposal addresses the NIH priority: To address HIV-associated comorbidities, coinfections and complications, which includes Malignancies as a category. HIV infection is a known risk factor for cervical cancer, with WLWH having an approximate 6-fold increased risk of developing cervical cancer. The overall goals of the AVANÇO Research Consortium include: 1) Establish sustainable research infrastructure to perform multi-institutional research studies related to HIV-associated malignancies across institutions in the US, Brazil and Mozambique. We will build a comprehensive research program focused on identifying novel, low-cost and technologically feasible approaches for the prevention, diagnosis, and treatment of cervical cancer in WLWH in LMICs. 2) Conduct two Research Projects that advance the development of promising low-cost technologies focused on the diagnoses of high-grade cervical dysplasia and invasive cervical cancer among WLWH. 3) Facilitate and enhance the professional development of junior investigators to conduct HIV- associated malignancy research in Mozambique and Brazil. Through our Developmental Core and Shared Resource Core, we will build research capacity and collaboration through formal research training courses, pilot project funding, and implementation of a Project ECHO® program for research capacity building focused on mentoring and supporting early-career investigators.