Project 1

项目1

• 批准号: 10598936
• 负责人: regis kreitchmann
• 金额: $ 37.01万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598936
• 关键词: AIDS related cancer; Ablation; Acetic Acids; Address; Advanced Development; Algorithmic Analysis; Artificial Intelligence; Behavioral Sciences; Biomedical Engineering; Biopsy; Brazil; Categories; Cervical; Cervical Cancer Screening; Cervical Intraepithelial Neoplasia; Cervical dysplasia; Cessation of life; Characteristics; Clinical; Cold Therapy; Collaborations; Colposcopes; Colposcopy; Country; Cytology; Detection; Development; Devices; Diagnosis; Diagnostic; Early Diagnosis; Early treatment; El Salvador; Epidemiology; Funding; Goals; Guidelines; HIV; HIV Infections; HIV Seronegativity; HIV/AIDS; Human Papillomavirus; Image; Image Analysis; Incidence; Infrastructure; Institution; Instruction; Lesion; Libraries; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Medical; Mentors; Modality; Modeling; Mozambique; Optical Biopsy; Pathology; Patients; Performance; Pilot Projects; Predictive Value; Prevalence; Prevention; Prevention approach; Provider; Recommendation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resolution; Resource Sharing; Resource-limited setting; Resources; Risk; Risk Factors; Sensitivity and Specificity; Services; Specificity; Speed; Technology; Testing; Texas; Time; Training; Triage; United States National Institutes of Health; Virus Diseases; Vision; Visit; Visual; Woman; World Health Organization; accurate diagnosis; automated image analysis; career; cervical biopsy; cervical cancer prevention; co-infection; comorbidity; cost; design; follow-up; formative assessment; image archival system; loop electrosurgical excision procedure; low and middle-income countries; medically underserved; microendoscope; multimodality; novel; overtreatment; point of care; premalignant; programs; prospective; research study; screening; skills; standard of care; treatment program; underserved area; usability; user centered design

ABSTRACT The overall vision of the AVANÇO Research Consortium is to establish sustainable infrastructure to develop research programs focused on HIV-associated malignancies in Brazil and Mozambique. The research theme chosen for this U54 HIV-Associated Malignancy Research Center (HAMRC) is to develop novel, low-cost and technologically feasible approaches for cervical cancer screening, diagnosis, and treatment in women living with HIV (WLWH) in low- and middle-income countries (LMICs). This HAMRC will be a collaboration between institutions in the US, Mozambique and Brazil and includes investigators with expertise in HIV/AIDS, Cervical Cancer, Bioengineering, Pathology, Epidemiology and Behavioral Science. The investigators have several ongoing scientific and clinical collaborations which include projects across all three countries. Our proposal addresses the NIH priority: To address HIV-associated comorbidities, coinfections and complications, which includes Malignancies as a category. HIV infection is a known risk factor for cervical cancer, with WLWH having an approximate 6-fold increased risk of developing cervical cancer. The overall goals of the AVANÇO Research Consortium include: 1) Establish sustainable research infrastructure to perform multi-institutional research studies related to HIV-associated malignancies across institutions in the US, Brazil and Mozambique. We will build a comprehensive research program focused on identifying novel, low-cost and technologically feasible approaches for the prevention, diagnosis, and treatment of cervical cancer in WLWH in LMICs. 2) Conduct two Research Projects that advance the development of promising low-cost technologies focused on the diagnoses of high-grade cervical dysplasia and invasive cervical cancer among WLWH. 3) Facilitate and enhance the professional development of junior investigators to conduct HIV- associated malignancy research in Mozambique and Brazil. Through our Developmental Core and Shared Resource Core, we will build research capacity and collaboration through formal research training courses, pilot project funding, and implementation of a Project ECHO® program for research capacity building focused on mentoring and supporting early-career investigators.

抽象的 Avanço研究联盟的总体愿景是建立可持续的基础设施 开发研究针对巴西与艾滋病毒相关的恶性肿瘤的研究计划 莫桑比克。为U54 HIV相关的恶性研究选择的研究主题 中心（HAMRC）是为开发新颖，低成本和技术可行的方法 宫颈癌筛查，诊断和治疗艾滋病毒（WLWH）的低和妇女的治疗 中等收入国家（LMIC）。这个HAMRC将是机构之间的合作 美国，莫桑比克和巴西，包括艾滋病毒/艾滋病专业知识的调查员，宫颈 癌症，生物工程，病理学，流行病学和行为科学。调查人员 进行了几次正在进行的科学和临床合作，其中包括这三个项目 国家。 我们的建议涉及NIH的优先事项：解决与HIV相关的合并症，共同感染 和并发症，其中包括Malignancys作为类别。艾滋病毒感染是已知的危险因素 对于宫颈癌，WLWH的宫颈风险大约增加了6倍 癌症。 Avanço研究联盟的总体目标包括： 1）建立可持续的研究基础设施以进行多机构研究研究 与美国，巴西和莫桑比克的机构之间与艾滋病毒相关的恶性肿瘤有关。我们 将建立一个全面的研究计划，旨在识别新颖，低成本和 在技​​术上可行的方法，用于预防，诊断和治疗宫颈 LMIC中的WLWH癌症。 2）进行两个研究项目，以推动承诺低成本的发展 专注于诊断高级宫颈发育不良和侵入性宫颈的技术 WLWH中的癌症。 3）促进和增强初级研究人员的专业发展，以进行HIV- 莫桑比克和巴西的相关恶性研究。通过我们的发展核心 并共享资源核心，我们将通过公式建立研究能力和协作 研究培训课程，试点项目资金以及项目Echo®计划的实施 用于研究能力建设，专注于心理和支持早期研究人员。