Free-living and in-lab effects of sedentary time on cardiac autonomic nervous system function in youth with overweight/obesity

久坐时间对超重/肥胖青少年心脏自主神经系统功能的自由生活和实验室影响

• 批准号: 10598404
• 负责人: Kelsey Lynn McAlister
• 金额: $ 4.66万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598404
• 关键词: Acute; Affect; Age; Automobile Driving; Autonomic nervous system; Behavior Therapy; Behavioral; Cardiac; Cardiovascular Diseases; Childhood; Cognition; Data Collection; Development; Devices; Disease Outcome; Disease Progression; Electrocardiogram; Equilibrium; Exercise; Frequencies; Funding; Health; Heart; Heart Rate; Hour; Individual; Interruption; Intervention; Knowledge; Link; Measures; Mediating; Methodology; Nervous System Physiology; Obesity; Outcome; Overweight; Pathway interactions; Persons; Phase; Physical activity; Physiological; Physiological Processes; Population; Prevention; Public Health; Randomized, Controlled Trials; Research Design; Research Personnel; Rest; System; Testing; Time; United States National Institutes of Health; Walking; Work; Youth; cardiovascular disorder risk; fighting; fitness; glucose metabolism; heart rate variability; high risk; improved; indexing; innovation; insight; mortality; response; sedentary

PROJECT ABSTRACT Cardiovascular disease (CVD) is a significant public health burden and remains the leading cause of mortality among the U.S population. CVD progression can originate during childhood, and youth with overweight and obesity (OW/OB) have an increased risk for CVD development. One mechanism that contributes to the development of CVD is imbalanced cardiac autonomic nervous system (ANS) function. The cardiac ANS governs the heart’s response to everyday conditions via sympathetic and parasympathetic modulation, in which balance of the sympathetic and parasympathetic systems indicates healthy cardiac ANS function. However, youth with OW/OB present overactivation of the sympathetic modulation of the heart, which is strongly associated with several adverse health outcomes. Studies in youth demonstrated that increased sedentary time (ST) is related to higher CVD risk. However, it is unknown whether the associations between ST and CVD are due to time displaced from physical activity to ST or due to underlying physiological processes stimulated by ST. Reduced cardiac ANS balance may be mediating the ST and CVD risk association, but few researchers have examined the associations between ST and cardiac ANS function, and none have examined associations within a day or within a person, and have not experimentally manipulated prolonged ST. Understanding the relationship of ST to cardiac ANS function may provide insight toward methodologies to alleviate CVD development, especially in youth with OW/OB who are at significantly higher risk for CVD. This project aims to leverage data collection opportunities from the NIH-funded Sedentary Breaks Study 3 (P.I. Dr. Britni Belcher; R01DK12333) to elucidate observational and experimental relationships between ST and cardiac ANS function via measures of heart rate variability in youth with OW/OB. The first phase of this project will investigate daily associations between objectively-measured ST and cardiac ANS function under habitual conditions. In the second phase, this project will have an innovative experimental component to determine the acute effects of interrupting ST on cardiac ANS function in-lab over seven consecutive days among three conditions: 1) continuous sitting (SIT), 2) sitting interrupted by 3-minute bouts of moderate-intensity walking every 30 minutes (SIT+WALK), and 3) sitting interrupted by a single 18-minute bout of moderate-intensity walking (EX).

项目摘要 心血管疾病（CVD）是一个重大的公共卫生负担，仍然是死亡的主要原因 在美国人口中。CVD进展可以起源于儿童时期，超重和肥胖的青年人， 肥胖（OW/OB）增加了CVD发展的风险。一种机制，有助于 CVD的发展是心脏自主神经系统（ANS）功能不平衡。心脏ANS支配 心脏对日常条件的反应通过交感神经和副交感神经调节，其中平衡 交感神经系统和副交感神经系统的恢复表明心脏ANS功能健康。然而，青年与 OW/OB表现为心脏交感神经调制的过度激活，这与 几个不利的健康后果。 对年轻人的研究表明，久坐时间（ST）增加与CVD风险增加有关。但据 尚不清楚ST和CVD之间的相关性是否是由于从体力活动到ST的时间转移所致 或由于ST刺激的潜在生理过程。降低的心脏ANS平衡可能介导 ST和CVD风险相关，但很少有研究人员研究ST和心血管疾病之间的关系。 ANS功能，没有人在一天内或一个人内检查过关联，也没有实验 了解ST段与心脏ANS功能的关系可能有助于了解 方法来缓解CVD的发展，特别是在年轻的OW/OB谁是显着 CVD的风险更高。 该项目旨在利用NIH资助的久坐休息研究3（P.I. 博士Britni Belcher; R 01 DK 12333），以阐明ST和 通过测量OW/OB青年的心率变异性来评估心脏ANS功能。该项目的第一阶段 将调查习惯性条件下客观测量的ST与心脏ANS功能之间的日常关联 条件在第二阶段，该项目将有一个创新的实验部分，以确定 在实验室连续7天中断ST对心脏ANS功能的急性影响， 条件：1）连续坐着（SIT），2）坐着被3分钟的中等强度步行打断， 30分钟（SIT+WALK），3）静坐，中间进行一次18分钟的中等强度步行（EX）。