Systems Immunology profiling of respiratory viral infections in vulnerable populations

摘要/摘要 数据管理和分析核心将为一带一路提供数据分析和管理服务 HIPC中心题为“脆弱人群中呼吸道病毒感染的系统免疫学概况”。 这一核心将服务于两个研究项目，从临床核心接收人口统计学和临床数据， 来自基因组学核心的高质量组学数据，以及来自自适应的高维细胞仪 表型核心。数据管理和分析核心将确保采用统一的实验方法 为所有项目和核心进行设计和分析，负责所有项目的数据和信息流动 负责向ImmPort提交已完成的数据集/项目； 协助其他中心成员和核心向免疫空间、地球观测组织和其他公共档案提交申请。至 为了实现这些目标，DMAC将利用贝纳罗亚现有的基础设施和专业知识 研究所。数据管理和分析核心有四个具体目标，具体目标1、 数据管理和分析核心将为所有一带一路重债穷国项目提供分析服务和咨询。 在具体目标2中，数据管理和分析核心将提供中央存储、管理和 一带一路重债穷国中心生成的数据的信息安全。在具体目标3中，数据管理和 分析核心将把数据管理基础设施与基因组学、适应性表型、临床 和管理核心。在具体目标4中，数据管理和分析核心将协调 根据NIAID标准，及时向ImmPort和其他储存库提交BRI重债穷国数据集， 和数据共享计划。数据将按照现有的格式标准和元数据提交 便于与其他重债穷国调查人员的数据以及与ImmPort工具集成的注解标准 数据检索、可视化和分析。数据管理和分析的关键影响因素 核心是HIPC中心数据的处理、跟踪和存储，以及可操作信息的呈现 在完成这两个研究项目的过程中，以及将重债穷国中心数据转化为 通过分析获得信息和解释。

SUMMARY/ABSTRACT The Data Management and Analysis Core will provide data analysis and management services for the BRI HIPC Center entitled “Systems immunology profiling of respiratory viral infections in vulnerable populations”. This core will serve both Research Projects, receiving demographic and clinical data from the Clinical Core, high quality ‘omics data from the Genomics Core, and high-dimensional cytometry from the Adaptive Phenotyping Core. The Data Management and Analysis Core will ensure a unified approach to experimental design and analysis for all projects and cores, be responsible for the flow of data and information across all components of the Center, be responsible for the submission of completed data sets/projects to ImmPort, and assist other Center members and Cores with submission to ImmuneSpace, GEO and other public archives. To meet these goals, the DMAC will leverage existing infrastructure and expertise that exist at the Benaroya Research Institute. The Data Management and Analysis Core has four Specific Aims, In Specific Aim 1, the Data Management and Analysis Core will provide analysis services and consultation for all BRI HIPC projects. In Specific Aim 2, the Data Management and Analysis Core will provide central storage, management and information security for data generated by the BRI HIPC Center. In Specific Aim 3, the Data Management and Analysis Core will integrate data management infrastructure with the Genomics, Adaptive Phenotyping, Clinical and Administrative Cores. In Specific Aim 4, the Data Management and Analysis Core will coordinate the timely submission of BRI HIPC data sets to ImmPort and other repositories, according to the NIAID standards, and the data sharing plan. Data will be submitted in conformance with existing format standards and meta-data annotation standards to facilitate integration with data from other HIPC investigators and with ImmPort tools for data retrieval, visualization, and analysis. The key impactful features of the Data Management and Analysis Core are the processing, tracking, and storage of HIPC Center data, the presentation of actionable information in the process of completing both Research Projects, and the transformation of HIPC Center data into information and interpretation via analysis.