Experience-dependent plasticity of auditory processing for vocal communication

声音交流听觉处理的经验依赖性可塑性

• 批准号: 10599250
• 负责人: Chad Daniel Meliza
• 金额: $ 34.28万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10599250
• 关键词: Acoustic Stimulation; Acoustics; Affect; Area; Auditory; Auditory Perception; Auditory area; Auditory system; Birds; Brain; Cell membrane; Cells; Chick; Classification; Communication; Communication impairment; Complex; Cues; Data; Development; Developmental Communication Disorders; Developmental Process; Disease; Dyslexia; Electron Microscopy; Electrophysiology (science); Environment; Exposure to; Face; Failure; Fire - disasters; Foundations; Goals; Hearing; Human; Immunofluorescence Immunologic; Impairment; Infant; Injections; Intrinsic drive; Language; Language Development; Language Development Disorders; Learning; Life; Link; Measurement; Measures; Membrane; Memory; Modeling; Neurons; Noise; Parents; Patients; Perception; Phase; Phonetics; Physiological; Poverty; Probability; Process; Property; Protein Analysis; Research; Role; Shapes; Signal Transduction; Slice; Social Environment; Songbirds; Speech; Speech Development; Speech Perception; Speech Sound; Stimulus; Structure; Systems Development; Testing; auditory processing; bird song; design; early experience; effective intervention; effective therapy; experience; experimental study; extracellular; in vivo; insight; neural; neuromechanism; noise exposure; protein expression; protein transport; response; sound; specific language impairment; statistics; tutoring; vocalization; zebra finch

PROJECT SUMMARY Many developmental communication disorders, such as speech sound disorder, specific language impairment, and dyslexia, are associated with central auditory processing deficits that affect phonetic perception. Infants learn how to classify the phonemes of their native language(s) through exposure to speech in the first year of life, but surprisingly little is known about the neural mechanisms of this key developmental process. The overarching goal of this project is to understand how complex signals like speech shape cellular and circuit properties in the central auditory areas responsible for decoding them. This research uses the zebra finch, a well-established model for auditory processing and learning. Like speech, birdsong has a complex spectral and temporal structure, and young birds need to hear song for normal development of auditory perception. Using the zebra finch model enables an approach that combines strong experimental control of the acoustic structure, social context, and timing of song experience, with intracellular and extracellular electrophysiological measurements and analyses of protein expression and trafficking. During a critical stage in vocal development, neurons in a cortical-level area involved in auditory learning develop diverse intrinsic properties that influence how they process communication sounds. Aim 1 examines the acoustic stimuli required for this plasticity to occur. Aim 2 investigates the mechanism of this experience- dependent intrinsic plasticity. Aim 3 tests how experience affects auditory processing in noisy conditions. By identifying how the timing and structure of auditory experience shape development at the single-cell level in a well-described learning task, this research has significant implications for understanding how impoverished environments can lead to auditory processing deficits associated with a wide range of human communication disorders.

项目摘要 许多发展性沟通障碍，如语音障碍，特定语言 障碍和诵读困难与影响语音的中枢听觉处理缺陷有关， perception.婴儿通过接触来学习如何对母语的音素进行分类 在生命的第一年就开始说话，但令人惊讶的是，人们对这一过程的神经机制知之甚少。 关键的发展过程。这个项目的首要目标是了解如何复杂 像语音形状的信号细胞和中央听觉区域的电路特性负责 解码它们这项研究使用了斑胸草雀，一种成熟的听觉处理模型 和学习像语言一样，鸟鸣声也有复杂的光谱和时间结构， 听觉的正常发展需要听歌曲。利用斑胸草雀模型 使一种方法，结合了强大的实验控制的声学结构，社会 背景和歌曲体验的时间，细胞内和细胞外电生理 蛋白质表达和运输的测量和分析。在声乐的关键阶段， 在发育过程中，参与听觉学习的皮质水平区域的神经元发育出不同的内在神经元 影响它们如何处理交流声音的特性。目标1检查声学 这种可塑性发生所需的刺激。目的2研究这种经验的机制- 依赖的内在可塑性Aim 3测试了经验如何影响嘈杂环境中的听觉处理 条件通过识别听觉体验的时间和结构如何塑造发展， 单细胞水平在一个良好的描述学习任务，这项研究具有重大意义， 了解贫困的环境如何导致听觉处理缺陷， 患有多种人类交流障碍