权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Overcoming vaccine-associated hypoxia with advanced biomaterials to enhance cancer immunotherapy

利用先进生物材料克服疫苗相关缺氧以增强癌症免疫治疗

基本信息

批准号：
10612093
负责人：
Stephen Matthew Hatfield
金额：
$ 45.1万
依托单位：
NORTHEASTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612093
关键词：
Address Adjuvant American Antigen-Presenting Cells Antitumor Response Autologous Tumor Cell Automobile Driving Biocompatible Materials Breast Cancer Model CD8B1 gene Cancer Etiology Cancer Vaccine Related Development Cancer Vaccines Cell physiology Cells Cessation of life Characteristics Clinical Cross-Priming Data Dendritic Cells Dendritic cell activation Distant Metastasis Dose Engineering Environment Exhibits Future Growth Homing Human Hyaluronic Acid Hypoxia Immune Immune checkpoint inhibitor Immune response Immune system Immunologic Tests Immunosuppression Immunotherapy In Vitro Injectable Irradiated tumor Laboratories Malignant Neoplasms Malignant neoplasm of prostate Mechanics Mediating Metastatic Prostate Cancer Mus Neoplasm Transplantation Outcome Oxygen Patient-Focused Outcomes Patients Peripheral Play Polymers Porosity Positioning Attribute Primary Neoplasm Property Prostate Cancer therapy Prostatic Neoplasms Recurrent Malignant Neoplasm Research Role Safety Site Specificity Stress Syringes T cell response T memory cell T-Lymphocyte Temperature Testing Therapeutic Toxic effect Transplantation Treatment Efficacy Tumor Immunity Vaccines anti-tumor immune response biomaterial compatibility cancer immunotherapy cancer recurrence cancer vaccination combat cryogel draining lymph node experimental study functional restoration immune activation immunogenic immunoregulation improved in vivo innovation insight lymph nodes men migration mouse model neoplastic cell novel particle personalized cancer therapy polymerization prevent prophylactic prostate cancer model recruit response scaffold supplemental oxygen synergism tool tumor tumor microenvironment tumor-immune system interactions vaccine efficacy

项目摘要

Project Summary Overcoming the poor efficacy of tumor cell vaccines will require enhancing activation of the immune system and preventing an immunosuppressive tumor microenvironment such as local hypoxia. In this proposal, we will address this critical need by engineering tumor cell vaccines with advanced oxygen-releasing biomaterials (O2- cryogels) to combat hypoxia-driven immunosuppression and improve antitumor immune responses in relevant mouse models of prostate cancer. Our preliminary data in mice indicate that: (i) O2-cryogels can reverse local hypoxia and restore the function of key immune cells (dendritic cells; DCs); (ii) once in the body, cryogel vaccines efficiently localize transplanted tumor cells, controllably release immunomodulatory factors, and recruit large numbers of DCs from the host; and (iii) elicit a specific and robust vaccine-induced T cell-mediated antitumor immunity. Here, we will optimize the characteristics of O2-cryogels for maximum antitumor efficacy and safety; and assess their ability to suppress the local hypoxic stress and improve DC recruitment, activation, and homing to the draining lymph nodes. Finally, we will test O2-cryogel vaccines in prophylactic and therapeutic mouse models of prostate cancer to determine their ability to induce specific, effective, and long-lasting antitumor immune responses. This proposal may have a sustained impact on the field by defining a new avenue of cancer immunotherapy that operates independently but synergizes with other therapies.

项目总结

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Biomaterials Recycling: A Promising Pathway to Sustainability.

DOI：
10.3389/fbiom.2023.1260402
发表时间：
2023-11
期刊：
Frontiers in biomaterials science
影响因子：
0
作者：
Paulina Wiśniewska;M. Saeb;S. Bencherif
通讯作者：
Paulina Wiśniewska;M. Saeb;S. Bencherif

Endothelial glycocalyx sensitivity to chemical and mechanical sub-endothelial substrate properties.

DOI：
10.3389/fbioe.2023.1250348
发表时间：
2023
期刊：
Frontiers in bioengineering and biotechnology
影响因子：
5.7
作者：
通讯作者：

Biomaterial-assisted local oxygenation safeguards the prostimulatory phenotype and functions of human dendritic cells in hypoxia.

DOI：
10.3389/fimmu.2023.1278397
发表时间：
2023
期刊：
Frontiers in immunology
影响因子：
7.3
作者：
通讯作者：

Synthesis and Characterization of Folic Acid-Functionalized DPLA-co-PEG Nanomicelles for the Targeted Delivery of Letrozole.

DOI：
10.1021/acsabm.3c00041
发表时间：
2023-05-15
期刊：
ACS APPLIED BIO MATERIALS
影响因子：
4.7
作者：
Rostami, Neda;Gomari, Mohammad Mahmoudi;Abdouss, Majid;Moeinzadeh, Alaa;Choupani, Edris;Davarnejad, Reza;Heidari, Reza;Bencherif, Sidi A
通讯作者：
Bencherif, Sidi A