Quantitative Analysis

抽象-核心D 核心D将向调查人员提供计算建模和统计分析工具和服务 CTMR。通过将生物学、工程学和计算机的方法结合起来，挑战是将 关注肌肉和运动科学领域对多尺度肌肉生物物理学的新认识 -从分子到运动。在这样做的过程中，解释肌肉如何发展、功能的统一理论 并有功能障碍的疾病和影响，其他生理系统将发展。核心将会 提供用于多尺度研究的宝贵的多尺度计算工具和可视化软件 关于新陈代谢(能量供应)和机械(能量需求/使用)，这些变化是如何发展的 肌肉以及它们在骨骼肌疾病中如何改变。在这样做的过程中，核心将开发符合以下条件的模型 提供信息并提供预测能力，可指导实验设计并建议目标 开发新的治疗方法来治疗疾病。中开发的模型和分析工具 这一核心将加快翻译肌肉研究的步伐。

ABSTRACT – Core D Core D will provide computational modeling and statistical analysis tools and services to investigators in the CTMR. By combining approaches from biology, engineering and computing, the challenge is to transform the field of muscle and movement sciences by focusing on a new understanding of multi-scale muscle biophysics – from molecules to movement. In doing so, the unifying theory explaining how muscle develops, functions and has dysfunction with disease and impacts other physiological systems will be developed. The core will provide invaluable mulit-scale computational tools and visualization software to be used in multi-scale research on metabolism (energy supply) and mechanical (energy demand/use), how these changes in developing muscle and how they are altered in skeletal muscle disease. In doing so, the core will develop models that are informative and provide predictive power that can guide experimental design and suggest targets for development of novel therapeutic approaches to treat disease. The models and analytical tools developed in this core will accelerate the pace of translational muscle research.