Non-Invasive Technology (NIT) Core F

非侵入式技术 (NIT) 核心 F

• 批准号: 10270193
• 负责人: ESTHER M. STERNBERG
• 金额: $ 67.75万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10270193
• 关键词: Age-associated memory impairment; Aging; Autonomic nervous system; Behavioral; Biochemical; Cardiac; Cognition; Cognitive; Collection; Computers; Data; Data Collection; Data Science Core; Dimensions; Emotions; Frequencies; Genetic Transcription; Glass; Goals; Hand; Heart Rate; Hormones; Human; Immune; Impaired cognition; Investigation; Lead; Linguistics; Longevity; Mass Spectrum Analysis; Measures; Modeling; Molecular; Monitor; Motion; Motor; Online Systems; Participant; Pathologic; Pattern; Performance; Persons; Phenotype; Physical activity; Physiological; Positioning Attribute; Process; Rest; Short-Term Memory; Sleep; Speech; Stress; Technology; Time; Voice; Work; arm; base; biobehavior; biosignature; cognitive change; cohort; computerized data processing; cost; data streams; exhaustion; frailty; healthspan; heart rate variability; innovation; lexical; novel; personalized predictions; relating to nervous system; response; sedentary lifestyle; sleep quality; social; speech processing; systematic review; wearable device; web site

SUMMARY/ABSTRACT: Non-Invasive Technology Core F The Non-Invasive Technology (NIT) Core supports the goals and objectives of the Precision Aging Network (PAN) by leading the implementation and advancement of cutting edge non-invasive approaches to capture mobility (e.g., step counts, sleep, sedentary behavior, cardiac response, and physical frailty phenotypes), speech (e.g., prosodic and lexical features), and sweat biochemical signatures that can enhance the early assessment of the gap between cognitive healthspan and human lifespan. The aims of the NIT Core are to collect (1) mobility information (mobility performance and motor capacity) via both web-based data collection modules and wearable devices, (2) spontaneous speech information via computer-based audio recording, and (3) sweat based biosignatures via glass beads which PAN participants will roll in the palm of their hands. The NIT Core will process and curate the data for use in conjunction with the objectives of each of the four projects. The NIT Core will help position the PAN to implement innovative non-invasive technologies to predict individualized aging trajectories with respect to social, physiological, behavioral and molecular dimensions.

摘要/摘要：非侵入式技术核心F 非侵入性技术(NIT)核心支持精密老化的目标和目标 网络(PAN)，通过领导实施和推进尖端非侵入性方法 捕捉机动性(例如，步数、睡眠、久坐行为、心脏反应和身体虚弱 表型)、语音(例如，韵律和词汇特征)和汗液生化特征 对认知健康寿命和人类寿命之间差距的早期评估。NIT核心的目标 通过基于网络的数据收集(1)移动性信息(移动性性能和运动能力) 采集模块和可穿戴设备，(2)通过基于计算机的音频的自发语音信息 记录，和(3)通过玻璃珠子的汗液生物签名，PAN参与者将在手掌中滚动 他们的手。NIT核心将处理和管理数据，以便与每个 四个项目。NIT核心将帮助PAN实施创新的非侵入性技术 从社会、生理、行为和分子方面预测个性化的衰老轨迹 尺寸。