The Center of Excellence in Addiction Studies (CEAS)
成瘾研究卓越中心 (CEAS)
基本信息
- 批准号:10270346
- 负责人:
- 金额:$ 128.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-15 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAcute PainAddictive BehaviorAddressAmygdaloid structureAnimalsAnxietyApplications GrantsAreaArizonaBasal GangliaBehavioralBehavioral AssayBiologyBrainBrain regionCRISPR/Cas technologyCellsChemicalsCholecystokininClinicalCognitionCognitiveCollaborationsComplementCorpus striatum structureCorticotropin-Releasing HormoneDataDevelopmentDiseaseDopamineDynorphinsEducationElementsEndocannabinoidsEnsureEvaluationEventExecutive DysfunctionFacultyFundingFutureGenesGeneticGenetic TechniquesGlutamatesGoalsHealth ProfessionalHealth SciencesImpairmentImpulsive BehaviorImpulsivityIndividualLeadLeadershipLettersLinkMeasurementMeasuresMediator of activation proteinMethodsModernizationMolecularMolecular TargetMotivationMusNational Institute of Drug AbuseNegative ReinforcementsNeurosciencesNeurotransmittersNew MexicoNucleus AccumbensOpioidOpioid AntagonistOpioid PeptideOutcomeOutcome MeasurePainPain ClinicsPain ResearchPain managementPatientsPersistent painPharmaceutical PreparationsPhasePhysiciansPilot ProjectsPopulationProcessProgram Research Project GrantsPublic HealthRattusRelapseReproducibilityResearchResearch PersonnelResearch Project GrantsResearch SupportResolutionRewardsScienceSecureServicesSignal TransductionSpecificityStandardizationStrategic PlanningStressStructureStudentsSubstance AddictionSubstance abuse problemSystemTechniquesTexasUnderrepresented PopulationsUnited StatesUnited States National Institutes of HealthUniversitiesWithdrawalWorkaddictionbasebiological adaptation to stressbrain circuitrychronic paincognitive functiondetection methoddrug addiction therapydrug of abusedrug reinforcementdrug relapseexecutive functionflexibilityfrontal lobeinsightkappa opioid receptorsmillisecondnegative affectneural circuitneurochemistrynovel strategiesoperationopioid epidemicopioid useopioid withdrawaloptogeneticspreventranpirnaserecruitrelating to nervous systemstemtemporal measurementtherapy developmenttranslational approachtreatment strategy
项目摘要
We propose to establish a Center of Excellence for Addiction Studies (CEAS) that will offer core services allowing
users to develop projects that will lead to new research in addiction. Addiction and relapse are characterized by
dysregulation of brain circuitry that involves diminished activity of brain reward circuits, increased responsiveness
of stress circuits and impaired functioning of executive cortical circuits. Neural changes are observed in the basal
ganglia, extended amygdala and prefrontal cortical regions and encompass a wide range of endogenous
neurotransmitters including dopamine, opioid peptides, endocannabinoids, corticotropin releasing factor (CRF),
dynorphin, glutamate and others. While chronic pain and addiction are different disorders, there is a remarkable
overlap between the influence of drugs of abuse and chronic pain on these circuits. Our faculty has broad
expertise in evaluation of mechanisms that underlie the maladaptations promoted by pain in these circuits. The
CEAS will be composed of four Cores and a Pilot Research Project. The Administrative Core will provide the
structural elements that will allow efficient functioning of the CEAS. The Genetic Targeting of Neural Circuits
Core will allow users to employ cutting edge genetic techniques including CRISPR/Cas9 gene editing,
chemogenetics and optogenetics to produce cell and circuit-specific manipulations to evaluate potential
mechanisms relevant to addiction. The Neuroanalytical Core will provide users with advanced methods of
measuring neurotransmitters with temporal resolution spanning milli-seconds to days and with spatial specificity
through advanced detection methods. The Behavioral Core will allow users to explore questions relevant to
addiction using behavioral assays that evaluate addictive processes including the influence of addictive drugs
on cognitive function. Investigators in the CEAS have worked together for many years and have shared and
individual research funding. Additionally, the CEAS will offer opportunities for other investigators at University
of Arizona as well as Arizona State University, Northern Arizona University, The University of New Mexico and
Texas Tech University Health Sciences Center at Lubbock and El Paso establishing a Southwestern region
engaged in addiction sciences. The CEAS will promote increased diversity in addiction research by recruiting
investigators and students from under-represented populations in neuroscience and addiction. The impact of the
CEAS will be to leverage established funding to develop new research on addiction research. In addition, the
impact of funds from the CEAS will be amplified by commitments of matching funds from the University of Arizona
and from a recently established Comprehensive Center of Pain and Addiction. The CEAS will provide key
services to its users that correspond with the goals of the NIDA to enhance addiction research with a goal of
development of therapies that can stem the opioid epidemic as well as impacting other substance abuse
disorders. The close collaboration between the Cores ensures high expertise in all areas of the addiction
research and will permit outcome measures emphasizing scientific rigor and reproducibility.
我们建议建立一个成瘾研究卓越中心(CEAS),提供核心服务,
用户开发项目,将导致新的研究成瘾。成瘾和复发的特征是
大脑回路失调,涉及大脑奖励回路活动减少,反应性增加
压力回路和执行皮层回路功能受损。在基底节中观察到神经变化
神经节,杏仁核和前额叶皮质区,包括广泛的内源性
神经递质包括多巴胺、阿片肽、内源性大麻素、促肾上腺皮质激素释放因子(CRF),
强啡肽、谷氨酸盐和其他物质。虽然慢性疼痛和成瘾是不同的疾病,但有一个显着的
滥用药物和慢性疼痛对这些回路的影响之间存在重叠。我们的教师有广泛的
在评估机制的专业知识,这些电路的疼痛促进适应不良的基础。的
CEAS将由四个核心和一个试点研究项目组成。行政核心将提供
这些结构要素将使CEAS有效运作。神经回路的遗传靶向
Core将允许用户使用包括CRISPR/Cas9基因编辑在内的尖端遗传技术,
化学遗传学和光遗传学,以产生细胞和电路特异性操作,
与成瘾有关的机制。神经分析核心将为用户提供先进的方法,
以毫秒到数天的时间分辨率和空间特异性测量神经递质
通过先进的检测方法。行为核心将允许用户探索与以下内容相关的问题:
使用行为测定法评价成瘾过程(包括成瘾药物的影响)的成瘾
对认知功能的影响CEAS的调查人员已经合作多年,并分享了
个人研究经费。此外,CEAS将为大学的其他研究人员提供机会
以及亚利桑那州立大学、北方亚利桑那大学、新墨西哥州大学和
位于拉伯克和埃尔帕索的德克萨斯理工大学健康科学中心建立了西南地区
从事成瘾科学研究。CEAS将通过招募人员来促进成瘾研究的多样性
来自神经科学和成瘾领域代表性不足人群的研究人员和学生。的影响
CEAS将利用现有的资金来开发关于成瘾研究的新研究。此外该
来自CEAS的资金的影响将通过亚利桑那大学的匹配资金的承诺而扩大
以及最近成立的疼痛和成瘾综合中心。CEAS将提供关键
为用户提供符合NIDA目标的服务,以加强成瘾研究,
开发可以阻止阿片类药物流行并影响其他药物滥用的疗法
紊乱核心之间的密切合作确保了成瘾所有领域的高专业知识
研究,并将允许强调科学严谨性和可重复性的结果测量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Frank Porreca其他文献
Frank Porreca的其他文献
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{{ truncateString('Frank Porreca', 18)}}的其他基金
The Center of Excellence in Addiction Studies (CEAS)
成瘾研究卓越中心 (CEAS)
- 批准号:
10626079 - 财政年份:2021
- 资助金额:
$ 128.9万 - 项目类别:
The Center of Excellence in Addiction Studies (CEAS)
成瘾研究卓越中心 (CEAS)
- 批准号:
10469424 - 财政年份:2021
- 资助金额:
$ 128.9万 - 项目类别:
New Modalities for the Treatment of Pain and Drug Abuse-Administrative Core
治疗疼痛和药物滥用的新方式——管理核心
- 批准号:
9073234 - 财政年份:2017
- 资助金额:
$ 128.9万 - 项目类别:
Cortical opioid dysfunction in chronic pain
慢性疼痛中的皮质阿片类药物功能障碍
- 批准号:
9479906 - 财政年份:2016
- 资助金额:
$ 128.9万 - 项目类别:
Cortical opioid dysfunction in chronic pain
慢性疼痛中的皮质阿片类药物功能障碍
- 批准号:
9259931 - 财政年份:2016
- 资助金额:
$ 128.9万 - 项目类别:
Brain reward circuits and relief of ongoing pain
大脑奖励回路和缓解持续疼痛
- 批准号:
8431853 - 财政年份:2013
- 资助金额:
$ 128.9万 - 项目类别:
Brain reward circuits and relief of ongoing pain
大脑奖励回路和缓解持续疼痛
- 批准号:
9238757 - 财政年份:2013
- 资助金额:
$ 128.9万 - 项目类别:
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