Brain Inhibition Control and Child Obesity Risk

脑抑制控制和儿童肥胖风险

• 批准号: 10271122
• 负责人: Shan Luo
• 金额: $ 12.38万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10271122
• 关键词: Adolescence; Adolescent; Adult; Age; Anterior; Appetite Regulation; Attenuated; Award; Base of the Brain; Behavioral; Birth; Body Weight Changes; Body mass index; Brain; Brain imaging; Budgets; Calories; Caring; Child; Child Health; Childhood; Cognitive; Consumption; Cues; Data; Desire for food; Development; Diet; Eating; Effectiveness; Emotional; Energy Intake; Ethnic Origin; Exposure to; Face; Fetal Development; Food; Functional disorder; Funding; Future; Gestational Diabetes; Goals; Growth; Health Care Costs; Human; Hyperphagia; Image; Imaging Techniques; Intervention; Knowledge; Lead; Link; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mediator of activation protein; Mentored Research Scientist Development Award; Metabolic; Modeling; Multimodal Imaging; Newborn Infant; Obesity; Overweight; Paper; Pathway interactions; Personal Satisfaction; Play; Positioning Attribute; Prefrontal Cortex; Prevention strategy; Productivity; Program Development; Public Health; Publications; Race; Reaction Time; Research; Resolution; Rewards; Risk; Risk Factors; Role; Scientist; Signal Transduction; Site; Socioeconomic Status; Stimulus; Structure; Testing; Thick; Time; TimeLine; United States; United States National Institutes of Health; Visit; Waist-Hip Ratio; Weight; Work; base; brain circuitry; brain pathway; brain reward regions; career; cingulate cortex; cognitive development; early adolescence; exposure pathway; frontal lobe; high risk; improved; in utero; innovation; large scale data; middle childhood; multimodality; neuromechanism; obesity development; obesity in children; obesity prevention; obesity risk; offspring; prenatal exposure; preventive intervention; response; sex; social

Project Summary Childhood obesity rate has been increasing dramatically, at great cost for health care and wellbeing. It is highly likely that obesity will persist into adulthood; thus, identifying risk factors contributing to childhood obesity is extremely critical so that prevention strategies can be taken early to reduce the obesity rate. Research suggests that children who were exposed to gestational diabetes mellitus (GDM) in utero have increased propensity of developing obesity. However, there are few human studies aimed to understand the mechanisms explaining this relationship. The primary goal of the applicant’s K01 project was to investigate associations between GDM exposure and brain pathways implicated in appetite regulation, particularly metabolic and reward pathways. The overall goal of this R03 project is to extend findings from the applicant’s ongoing K01 study to test a hypothesis that in utero exposure to GDM may disrupt the prefrontal inhibition control circuitry, resulting in overeating and obesity. To accomplish this goal, the applicant and her team plan to leverage brain and adiposity data available through the Adolescent Brain Cognitive Development (ABCD) study, and 1) investigate relationships between GDM exposure and functional/structural correlates of inhibition control; and 2) use brain-based markers to predict changes in adiposity. This will be the largest study in humans to use multi-modal imaging techniques to examine neural mechanisms of the link between GDM exposure and obesity risk. The proposed study is an extension of the applicant’s K01 project, together by which will allow the candidate to have a comprehensive assessment of brain circuitry involved in appetite regulation and establish a brain-based working model explaining increased obesity risk among children exposed to GDM in utero.

项目摘要 儿童肥胖率一直在急剧上升，付出了医疗保健和福祉的巨大成本。它 肥胖很可能会持续到成年。因此，确定导致儿童的危险因素 肥胖至关重要，因此可以尽早采取预防策略来降低肥胖率。 研究表明，子宫内接触妊娠糖尿病（GDM）的儿童已经 肥胖发展的可靠性提高。但是，人类研究的目的很少 解释这种关系的机制。申请人K01项目的主要目标是调查 GDM暴露与食欲调节中实施的大脑通道之间的关联，特别是 代谢和奖励途径。该R03项目的总体目标是从 申请人正在进行的K01研究，以检验一个假设，即在子宫内暴露于GDM中可能会破坏 前额叶抑制控制电路，导致暴饮暴食和肥胖。为了实现这一目标， 申请人和她的团队计划利用青少年大脑可用的大脑和肥胖数据 认知发展（ABCD）研究，1）研究GDM暴露与 抑制控制的功能/结构相关； 2）使用基于大脑的标记来预测 肥胖。这将是人类最大的研究，用于使用多模式成像技术检查神经 GDM暴露与肥胖风险之间联系的机制。 拟议的研究是申请人的K01项目的扩展，一起将允许 候选人对涉及食欲调节的脑电路进行全面评估并建立 一个基于大脑的工作模型，解释了暴露于子宫内GDM的儿童肥胖风险的增加。