Identifying Associations between Brain Iron, Neurocognitive Networks and Protective Factors

识别脑铁、神经认知网络和保护因素之间的关联

基本信息

  • 批准号:
    10579909
  • 负责人:
  • 金额:
    $ 53.27万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-05-01 至 2026-02-28
  • 项目状态:
    未结题

项目摘要

Identifying Associations between Brain Iron, Neurocognitive Networks and Protective Factors Alzheimer’s disease (AD) involves accumulation of pathological levels of amyloid-beta (Aβ) and phospho-tau proteins. However, a significant proportion of individuals with AD pathology do not have clinical AD, indicating contributions of other factors. Novel in-vivo measures are required to track other factors contributing to AD-related cognitive declines. Increasing evidence suggests that age-related accumulation of brain iron and its correlates contribute to the manifestation of memory declines. Our recent neuroimaging results suggest that high brain iron concentration, measured with in vivo quantitative susceptibility mapping (QSM), is associated poor connectivity within brain memory networks. This proposal seeks to identify associations between QSM-based iron concentration and neurocognitive changes toward a goal of improving AD biomarkers. We will also define the interplay between QSM-based iron signal, AD pathology, inflammatory markers on cognitive declines. Finally, we will test the possibility that brain iron accumulation may be slowed by an antioxidant rich diet. We propose to study 140 healthy older adults using neuroimaging measures including fMRI and QSM, measures of CSF and plasma Aβ, p-tau and t-tau and inflammatory markers. Additional structural neuroimaging measures will include regional volumes, FLAIR imaging for quantification of WMH volumes and diffusion tensor imaging for quantification of regionally distributed white matter connectivity. A subset of participants will be complete the same CSF and imaging measures approximately 3 years later. We aim to identify (1) effects of QSM-based iron signal on functional and structural brain networks supporting cognition; (2) associations between brain iron, inflammatory markers, AD pathology and cognitive declines and; (3) modifiers of brain iron or its effects on cognition. We will test hypotheses that high QSM-based brain iron is associated with low connectivity in memory circuits independently of AD pathology but may and synergistically interacts with AD over time. We will also test the hypothesis that reserve factors will offset the effects of brain iron on cognitive functions via mechanisms of brain maintenance or plastic functional brain reorganization of large-scale brain functional networks in some older adults.
确定脑铁,神经认知网络和

项目成果

期刊论文数量(0)
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BRIAN Timothy GOLD其他文献

BRIAN Timothy GOLD的其他文献

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{{ truncateString('BRIAN Timothy GOLD', 18)}}的其他基金

Reduced BBB Water Exchange as a Preclinical Biomarker of Small Vessel Disease
BBB 水交换减少作为小血管疾病的临床前生物标志物
  • 批准号:
    10369462
  • 财政年份:
    2022
  • 资助金额:
    $ 53.27万
  • 项目类别:
Identifying Associations between Brain Iron, Neurocognitive Networks and Protective Factors
识别脑铁、神经认知网络和保护因素之间的关联
  • 批准号:
    10206402
  • 财政年份:
    2021
  • 资助金额:
    $ 53.27万
  • 项目类别:
Identifying Associations between Brain Iron, Neurocognitive Networks and Protective Factors
识别脑铁、神经认知网络和保护因素之间的关联
  • 批准号:
    10395546
  • 财政年份:
    2021
  • 资助金额:
    $ 53.27万
  • 项目类别:
Contributions of Alzheimer's Pathology and Cerebrovascular Factors to Cognitive Aging
阿尔茨海默病病理学和脑血管因素对认知衰老的影响
  • 批准号:
    9448188
  • 财政年份:
    2017
  • 资助金额:
    $ 53.27万
  • 项目类别:
The effects of bilingualism on age-related cognitive and neurobiological declines
双语对与年龄相关的认知和神经生物学衰退的影响
  • 批准号:
    7729395
  • 财政年份:
    2009
  • 资助金额:
    $ 53.27万
  • 项目类别:
The effects of bilingualism on age-related cognitive and neurobiological declines
双语对与年龄相关的认知和神经生物学衰退的影响
  • 批准号:
    8134817
  • 财政年份:
    2009
  • 资助金额:
    $ 53.27万
  • 项目类别:
The effects of bilingualism on age-related cognitive and neurobiological declines
双语对与年龄相关的认知和神经生物学衰退的影响
  • 批准号:
    8316218
  • 财政年份:
    2009
  • 资助金额:
    $ 53.27万
  • 项目类别:
The effects of bilingualism on age-related cognitive and neurobiological declines
双语对与年龄相关的认知和神经生物学衰退的影响
  • 批准号:
    8516420
  • 财政年份:
    2009
  • 资助金额:
    $ 53.27万
  • 项目类别:
The effects of bilingualism on age-related cognitive and neurobiological declines
双语对与年龄相关的认知和神经生物学衰退的影响
  • 批准号:
    7930649
  • 财政年份:
    2009
  • 资助金额:
    $ 53.27万
  • 项目类别:
UK-ADRC neuroimaging supplement: LATE and PART
UK-ADRC 神经影像补充:LATE 和 PART
  • 批准号:
    10170755
  • 财政年份:
    2006
  • 资助金额:
    $ 53.27万
  • 项目类别:
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