A mechanistic dissection of short and long term spatiotemporal learning in V1
V1 中短期和长期时空学习的机制剖析
基本信息
- 批准号:10579980
- 负责人:
- 金额:$ 41.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-03-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:Animal ModelBehaviorBehavioral AssayBrainCategoriesChemosensitizationCodeCognitionDissectionElectrophysiology (science)ElementsEventFeedbackFunctional ImagingGoalsHourImageInfluentialsInformation StorageInterneuronsLearningLong-Term PotentiationMediatingMemoryMental disordersModelingModernizationModificationMusMuscarinic Acetylcholine ReceptorMuscarinicsNeocortexNeurobiologyNeurosciencesOcular PhysiologyPatternPerceptionPhotic StimulationPhysiologicalPhysiologyPlayProbabilityProcessProtocols documentationRapid screeningReceptor SignalingRoleSensorySignal PathwaySignal TransductionStimulusStructureSystemTestingTimeTrainingTransition ElementsVisualVisual SystemWorkantagonistarea striatabasal forebraincholinergiccholinergic neuroncognitive functionexperienceexperimental studyhuman modelinsightmemory recallmotor controlneocorticalnervous system disorderneural networkneuromechanismpredictive modelingresponsesensory cortexspatiotemporaltoolvisual informationvisual stimulus
项目摘要
Project Summary
The primary visual cortex (V1) can learn to encode spatiotemporal relationships based on visual
experience and uses the resulting functional memory to actively predict how the visual scene will unfold in
time. This demonstrates expression of a canonical cortical function localized in an experimentally
accessible region. We propose to leverage the tools of modern neuroscience to mechanistically dissect
this ability in the mouse, with the overall aim of developing a description of how the neocortex learns to
represent temporal information. The primary goals of this work are first to understand how similar forms of
visual stimulation drive different forms of short and long-term plasticity that can encode either spatial or
temporal information, and second to identify the distinct mechanisms involved. In addition to their direct
relevance to sensory neurobiology, various psychiatric and neurological disorders, and visual physiology
our experiments will address the wider question of how cortical circuits learn to use temporal relationships
to build predictive models of the world, the answer to which remains as murky as it is critical for our
understanding of the brain.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeffrey Peter Gavornik其他文献
Jeffrey Peter Gavornik的其他文献
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{{ truncateString('Jeffrey Peter Gavornik', 18)}}的其他基金
A mechanistic dissection of short and long term spatiotemporal learning in V1
V1 中短期和长期时空学习的机制剖析
- 批准号:
9974010 - 财政年份:2020
- 资助金额:
$ 41.25万 - 项目类别:
A mechanistic dissection of short and long term spatiotemporal learning in V1
V1 中短期和长期时空学习的机制剖析
- 批准号:
10356128 - 财政年份:2020
- 资助金额:
$ 41.25万 - 项目类别:
Cortical mechanisms of learned spatial-temporal sequence coding
学习时空序列编码的皮质机制
- 批准号:
8425728 - 财政年份:2013
- 资助金额:
$ 41.25万 - 项目类别:
Cortical mechanisms of learned spatial-temporal sequence coding
学习时空序列编码的皮质机制
- 批准号:
9264583 - 财政年份:2013
- 资助金额:
$ 41.25万 - 项目类别:
Cortical mechanisms of learned spatial-temporal sequence coding
学习时空序列编码的皮质机制
- 批准号:
8978909 - 财政年份:2013
- 资助金额:
$ 41.25万 - 项目类别:
Cortical mechanisms of learned spatial-temporal sequence coding
学习时空序列编码的皮质机制
- 批准号:
8600324 - 财政年份:2013
- 资助金额:
$ 41.25万 - 项目类别:
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