A mechanistic dissection of short and long term spatiotemporal learning in V1

V1 中短期和长期时空学习的机制剖析

基本信息

项目摘要

Project Summary The primary visual cortex (V1) can learn to encode spatiotemporal relationships based on visual experience and uses the resulting functional memory to actively predict how the visual scene will unfold in time. This demonstrates expression of a canonical cortical function localized in an experimentally accessible region. We propose to leverage the tools of modern neuroscience to mechanistically dissect this ability in the mouse, with the overall aim of developing a description of how the neocortex learns to represent temporal information. The primary goals of this work are first to understand how similar forms of visual stimulation drive different forms of short and long-term plasticity that can encode either spatial or temporal information, and second to identify the distinct mechanisms involved. In addition to their direct relevance to sensory neurobiology, various psychiatric and neurological disorders, and visual physiology our experiments will address the wider question of how cortical circuits learn to use temporal relationships to build predictive models of the world, the answer to which remains as murky as it is critical for our understanding of the brain.
项目总结

项目成果

期刊论文数量(0)
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Jeffrey Peter Gavornik其他文献

Jeffrey Peter Gavornik的其他文献

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{{ truncateString('Jeffrey Peter Gavornik', 18)}}的其他基金

A mechanistic dissection of short and long term spatiotemporal learning in V1
V1 中短期和长期时空学习的机制剖析
  • 批准号:
    9974010
  • 财政年份:
    2020
  • 资助金额:
    $ 41.25万
  • 项目类别:
A mechanistic dissection of short and long term spatiotemporal learning in V1
V1 中短期和长期时空学习的机制剖析
  • 批准号:
    10356128
  • 财政年份:
    2020
  • 资助金额:
    $ 41.25万
  • 项目类别:
Cortical mechanisms of learned spatial-temporal sequence coding
学习时空序列编码的皮质机制
  • 批准号:
    8425728
  • 财政年份:
    2013
  • 资助金额:
    $ 41.25万
  • 项目类别:
Cortical mechanisms of learned spatial-temporal sequence coding
学习时空序列编码的皮质机制
  • 批准号:
    9264583
  • 财政年份:
    2013
  • 资助金额:
    $ 41.25万
  • 项目类别:
Cortical mechanisms of learned spatial-temporal sequence coding
学习时空序列编码的皮质机制
  • 批准号:
    8978909
  • 财政年份:
    2013
  • 资助金额:
    $ 41.25万
  • 项目类别:
Cortical mechanisms of learned spatial-temporal sequence coding
学习时空序列编码的皮质机制
  • 批准号:
    8600324
  • 财政年份:
    2013
  • 资助金额:
    $ 41.25万
  • 项目类别:

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