Anesthestic modulation of human memory during acute pain

急性疼痛期间人类记忆的麻醉调节

基本信息

批准号：
10242824
负责人：
Keith Michael Vogt
金额：
$ 18.9万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-15 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10242824
关键词：
Acute Pain Adrenergic Antagonists Adult Affect Age Amnesia Amygdaloid structure Analgesics Anesthesia procedures Anesthesiology Anesthetics Animals Anxiety Attenuated Aversive Stimulus Awareness Behavior Behavioral Brain Brain imaging Brain region Characteristics Clinical Clinical Research Cognitive Conscious Data Data Set Development Development Plans Dexmedetomidine Dose Emotions Evaluation Event Fentanyl Functional Magnetic Resonance Imaging General Anesthesia Goals Heart Rate Hippocampus (Brain)Human Image Incidence Individual Individual Differences Insula of Reil Investigation Lead Magnetic Resonance Imaging Measurable Measurement Measures Mediating Memory Mentors Methodology Methods Motivation Neuroanatomy Neurosciences Opioid Pain Pattern Performance Periodicity Pharmaceutical Preparations Pharmacology Physicians Physiological Placebos Post-Traumatic Stress Disorders Process Propofol Protocols documentation Psychology Psychometrics Psychophysiology Randomized Reaction Time Research Research Personnel Research Technics Running Scientist Sedation procedure Single-Blind Study Sleep Statistical Data Interpretation Stimulus Stress Structure Subconscious System Techniques Translational Research Universities Variant Work anxiety spectrum disorders arm base behavior measurement career development clinically relevant cognitive neuroscience cognitive task complement C2a conditioned fear conditioning design direct application experience hands on research human subject hypnotic imaging study implicit memory indexing medical schools meetings memory encoding multidisciplinary neuroimaging pain perception pain processing patient oriented prevent psychologic receptor relating to nervous system response sedative statistical learning

项目摘要

Project Summary (abstract): Despite routine use of sedative-hypnotic and analgesic agents (anesthetics) to prevent or ease suffering during aversive conditions, the effects of these agents on behavior and the neural systems that form memories, respond to threat, and process pain are poorly understood. This project will determine the memory-modulating effects of propofol, dexmedetomidine, and fentanyl in the context of periodic pain stimulation. It is a randomized, placebo- controlled, single-blind, parallel arm fMRI study in healthy adults (under age 40). Subjects will perform a memory encoding task while receiving periodic acute pain stimulation. Explicit and implicit memory will be quantified using response time and physiologic responses, including heart rate and electrodermal activity. Neuroimaging will localize brain activity and connectivity. Psychometric data relevant to pain and anxiety will be used to account for inter-individual differences. The central hypothesis is that, when forming memory during concomitant painful stimulation, three anesthetic agents, with different receptor pharmacology, will have distinct behavioral and physiologic response patterns, which are mediated by different activity within and interactions between the neural systems responsible for memory encoding, threat response, and pain processing. There are three scientific research goals of this patient-oriented career development proposal. The first is to determine how behavioral and physiologic measures of explicit and implicit memory are modulated by pain and the individual effects of the three anesthetics under investigation. The second aim is to determine the brain structures differentially engaged in memory encoding under pain and drug conditions, using task-related functional MRI and functional connectivity analyses. The third aim is to determine brain changes correlated to subject psychometric measures of anxiety, stress, sleep, and pain through multivariate psychophysiological interaction analysis. The scientific framework for this project has a direct application in better understanding the impact of memories formed during sedation with anesthetics while experiencing noxious stimuli. Additionally, further extension of this pharmacologic modulation technique to other cognitive neuroscience paradigms could provide a multidisciplinary framework for basic studies of memory formation, the genesis of dysregulated memories, and the necessary conditions for anesthetic-induced amnesia. In addition to the hands-on research experience of running a trial, achieved through the research aims, this project will advance the applicant into an independent physician scientist in anesthesiology through specific career-development activities. This will be accomplished through a combination of mentoring and evaluation meetings, national scientific/professional meetings, formal didactics, and local seminars/presentations. As part of professional development, coursework in multivariate statistical analysis techniques and cognitive and behavioral neuroscience is planned. The project will be conducted at the University of Pittsburgh, in the School of Medicine, which has outstanding support for clinical and translational research and an established record of developing physician scientists into independent investigators.

项目摘要（摘要）：尽管常规使用镇静催眠剂和镇痛药（麻醉剂），以防止或缓解痛苦厌恶条件，这些药物对行为和形成记忆的神经系统的影响威胁和过程疼痛知之甚少。该项目将确定记忆调节的效果在周期性疼痛刺激的背景下，丙泊酚，右美托咪定和芬太尼。这是一个随机的安慰剂 - 健康成年人（40岁以下）受控的单盲，平行手臂fMRI研究。主题将执行记忆在接受定期急性疼痛刺激时编码任务。明确和隐式内存将使用反应时间和生理反应，包括心率和耳皮活动。神经影像学会定位大脑活动和连通性。与疼痛和焦虑有关的心理测量数据将用于说明对于个体间的差异。中心假设是，在伴随疼痛期间形成记忆时刺激，三种具有不同受体药理的麻醉药物，将具有不同的行为和生理反应模式，这些模式是由内在的不同活性和神经之间的相互作用介导的负责记忆编码，威胁响应和疼痛处理的系统。有三个科学这项以患者为导向的职业发展计划的研究目标。首先是确定行为方式显性和隐式记忆的生理测量是由疼痛和个人影响调节的正在调查三种麻醉药。第二个目的是确定大脑结构差异参与在疼痛和药物条件下编码的记忆中，使用任务相关的功能MRI和功能连接分析。第三个目的是确定与主体心理测量指标相关的大脑变化通过多元心理生理相互作用分析，焦虑，压力，睡眠和疼痛。科学该项目的框架有直接应用，以更好地理解在在经历有害刺激的同时，用麻醉药进行麻醉。此外，该药理的进一步扩展针对其他认知神经科学范式的调节技术可以为多学科的框架提供记忆形成的基础研究，失调记忆的起源以及麻醉引起的失忆症。除了实现试验的动手研究经验外研究的目的是，该项目将使申请人成为独立的医师科学家通过特定的职业发展活动进行麻醉学。这将通过组合完成指导和评估会议，国家科学/专业会议，正式教学和当地研讨会/演讲。作为专业发展的一部分，多元统计分析的课程工作计划了技术，认知和行为神经科学。该项目将在大学进行匹兹堡医学院的匹兹堡，该学院对临床和转化研究有出色的支持以及将医师科学家发展成独立研究人员的既定记录。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Anesthesia and the neurobiology of fear and posttraumatic stress disorder.

DOI：
10.1097/aco.0000000000001176
发表时间：
2022-10-01
期刊：
Current opinion in anaesthesiology
影响因子：
0
作者：
通讯作者：

Wellness Principles Correlate With More Favorable Burnout Scores in Junior Anesthesiology Residents.

健康原则与初级麻醉住院医师更有利的倦怠评分相关。

DOI：
发表时间：
2020
期刊：
The journal of education in perioperative medicine : JEPM
影响因子：
0
作者：
Ungerman,ElizabethA;Vogt,KeithM;Sakai,Tetsuro;Metro,DavidG;Adams,PhillipS
通讯作者：
Adams,PhillipS

Financial Incentive, in Place of Nonclinical Time, Increases Faculty Involvement and Improves Resident Didactic Evaluation Scores in an Anesthesiology Residency Training Program.

用经济激励代替非临床时间，可以增加教师的参与并提高麻醉科住院医师培训计划中的住院医师教学评估分数。

DOI：
发表时间：
2019
期刊：
The journal of education in perioperative medicine : JEPM
影响因子：
0
作者：
Adams,DouglasR;Vogt,KeithM;Norton,CarolineM;Metro,DavidG
通讯作者：
Metro,DavidG

Neutral auditory words immediately followed by painful electric shock may show reduced next-day recollection.

DOI：
10.1007/s00221-022-06467-8
发表时间：
2022-11
期刊：
EXPERIMENTAL BRAIN RESEARCH
影响因子：
2
作者：
Norton, Caroline M.;Ibinson, James W.;Pcola, Samantha J.;Popov, Vencislav;Tremel, Joshua J.;Reder, Lynne M.;Fiez, Julie A.;Vogt, Keith M.
通讯作者：
Vogt, Keith M.