Airway microbiome and age 6y asthma phenotypes in 2 diverse multicenter cohorts
2 个不同多中心队列中的气道微生物组和 6 岁哮喘表型
基本信息
- 批准号:10242707
- 负责人:
- 金额:$ 22.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-21 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:16S ribosomal RNA sequencing3 year old5 year old6 year old9 year oldAffectAfrican AmericanAgeAreaAsthmaBostonBronchiolitisCCL7 geneChildChildhood AsthmaCohort StudiesCollaborationsComplexDataData SetDevelopmentDiagnosisDietDiseaseEarly identificationEnrollmentEnvironmentEnvironmental ExposureEpigenetic ProcessEuropeanExtrinsic asthmaFlavin MononucleotideFundingFutureGeneticGenetic Predisposition to DiseaseHeterogeneityHispanicsHospitalizationHuman MicrobiomeImmune responseInfantInterventionInterviewKnowledgeLiteratureLongterm Follow-upMediatingMedical RecordsMetabolicMetagenomicsMethodsMoraxellaNitric Oxide PathwayNoseOutcomeParentsPathogenesisPatternPersonsPhenotypePositioning AttributePrevention strategyPrimary PreventionProceduresProspective cohort studyRecurrenceReportingResearchResearch PersonnelRiboflavinRibosomal RNARiskRisk FactorsRoleSamplingShotgunsSiteSwabTechniquesTestingUnited States National Institutes of HealthViral Respiratory Tract InfectionWheezingWhole-Genome Shotgun Sequencingasthma preventioncohortdemographicsearly childhoodethnic diversityevidence basefollow-uphigh riskhigh risk populationhypopharynxindexinginfancyinnovationmicrobiomemicrobiome researchmodifiable risknasal swabpreventpsychosocialrRNA Genesracial and ethnicrespiratory microbiomewhole genome
项目摘要
PROJECT SUMMARY / ABSTRACT
Bronchiolitis is the #1 cause of hospitalization in US infants, with ~130,000 hospitalizations
annually. Small cohort studies (n<210) suggest that 40-50% of infants hospitalized with
bronchiolitis will later develop asthma. The greatest challenges for developing primary
prevention strategies for this large group of children (indeed, all children) are the very early
identification of modifiable risk factors and the heterogeneity of asthma. The 35th Multicenter
Airway Research Collaboration (MARC-35) study (U01AI-087881; Camargo, PI) is a 17-center
prospective cohort study that completed enrollment of 921 hospitalized infants with bronchiolitis
in 2014. In this diverse cohort (53% African-American or Hispanic), investigators have collected
biospecimens, including nasal swabs at the index hospitalization (median age 3 months) and at
an age 3y exam (R01AI-114552; Camargo, PI). Follow-up data include biannual parent
interviews and medical records to age 5 years, with ~90% follow-up to date. This UG3/UH3
application would: 1) extend the largest severe bronchiolitis cohort in the world (e.g., through an
age 6y in-person exam to diagnose and phenotype asthma), and 2) build on our local MARC-43
cohort of 120 healthy infants by adding 600 healthy infants from four diverse sites (total n=720).
Both cohorts undergo similar procedures (e.g., serial nasal swabs during early childhood). Our
overarching hypothesis is that airway Moraxella abundance is associated with increased risk of
childhood asthma, and our pilot data are supportive. In Aim 1, we will investigate the relation of
the airway microbiome in early infancy to risk of age 6y asthma among infants with severe
bronchiolitis (MARC-35). In Aim 2, we will do the same but among healthy infants (MARC-43).
In Aim 3, we will investigate the relation of longitudinal patterns of the airway microbiome (e.g.,
infancy, age 3y, age 6y) to risk of childhood asthma in the two cohorts combined. In a subset of
200 children (100 from each cohort), we will use whole genome shotgun (WGS) sequencing to
examine the relations of bacterial species and metabolic potential in early infancy to risk of
asthma. For all 3 Aims, we will examine if associations differ by asthma phenotype (e.g., allergic
asthma). The investigators are NIH-funded researchers working in an outstanding research
environment. The proposed project is innovative and, by providing a strong evidence base for
the future development of targeted microbiome interventions, advances research on the primary
prevention of asthma. Moreover, the two racially/ethnically-diverse cohorts will provide the
ECHO Consortium with comprehensive data on demographics, development, environmental
exposures, genetics, and outcomes from two already-harmonized, multicenter U.S. studies.
项目摘要/摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CARLOS A. CAMARGO其他文献
CARLOS A. CAMARGO的其他文献
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{{ truncateString('CARLOS A. CAMARGO', 18)}}的其他基金
Nasal microRNA during bronchiolitis and age 6y asthma phenotypes: MARC-35 cohort
细支气管炎和 6 岁哮喘表型期间的鼻 microRNA:MARC-35 队列
- 批准号:
10267407 - 财政年份:2020
- 资助金额:
$ 22.59万 - 项目类别:
Host genetics, early-life microbiome, and childhood asthma: MARC-43 Boston
宿主遗传学、生命早期微生物组和儿童哮喘:MARC-43 波士顿
- 批准号:
10742124 - 财政年份:2016
- 资助金额:
$ 22.59万 - 项目类别:
Nasal microRNA during bronchiolitis and age 6y asthma phenotypes: MARC-35 cohort
细支气管炎和 6 岁哮喘表型期间的鼻 microRNA:MARC-35 队列
- 批准号:
9215155 - 财政年份:2016
- 资助金额:
$ 22.59万 - 项目类别:
Airway microbiome and age 6y asthma phenotypes in 2 diverse multicenter cohorts
2 个不同多中心队列中的气道微生物组和 6 岁哮喘表型
- 批准号:
10012789 - 财政年份:2016
- 资助金额:
$ 22.59万 - 项目类别:
Nasal microRNA during bronchiolitis and age 6y asthma phenotypes: MARC-35 cohort
细支气管炎和 6 岁哮喘表型期间的鼻 microRNA:MARC-35 队列
- 批准号:
10062795 - 财政年份:2016
- 资助金额:
$ 22.59万 - 项目类别:
Comparative Effectiveness Research on Hospital Readmissions for COPD
慢性阻塞性肺病再入院的比较效果研究
- 批准号:
9768958 - 财政年份:2015
- 资助金额:
$ 22.59万 - 项目类别:
Comparative Effectiveness Research on Hospital Readmissions for COPD
慢性阻塞性肺病再入院的比较效果研究
- 批准号:
8885175 - 财政年份:2015
- 资助金额:
$ 22.59万 - 项目类别:
Comparative Effectiveness Research on Hospital Readmissions for COPD
慢性阻塞性肺病再入院的比较效果研究
- 批准号:
9147581 - 财政年份:2015
- 资助金额:
$ 22.59万 - 项目类别:
Comparative Effectiveness Research on Hospital Readmissions for COPD
慢性阻塞性肺病再入院的比较效果研究
- 批准号:
9349489 - 财政年份:2015
- 资助金额:
$ 22.59万 - 项目类别:
Infant specific-IgE, rhinovirus-C bronchiolitis, and incident asthma in MARC-35
MARC-35 中的婴儿特异性 IgE、鼻病毒 C 细支气管炎和哮喘事件
- 批准号:
9188529 - 财政年份:2014
- 资助金额:
$ 22.59万 - 项目类别:
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