Airway microbiome and age 6y asthma phenotypes in 2 diverse multicenter cohorts

2 个不同多中心队列中的气道微生物组和 6 岁哮喘表型

基本信息

  • 批准号:
    10242707
  • 负责人:
  • 金额:
    $ 22.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-21 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY / ABSTRACT Bronchiolitis is the #1 cause of hospitalization in US infants, with ~130,000 hospitalizations annually. Small cohort studies (n<210) suggest that 40-50% of infants hospitalized with bronchiolitis will later develop asthma. The greatest challenges for developing primary prevention strategies for this large group of children (indeed, all children) are the very early identification of modifiable risk factors and the heterogeneity of asthma. The 35th Multicenter Airway Research Collaboration (MARC-35) study (U01AI-087881; Camargo, PI) is a 17-center prospective cohort study that completed enrollment of 921 hospitalized infants with bronchiolitis in 2014. In this diverse cohort (53% African-American or Hispanic), investigators have collected biospecimens, including nasal swabs at the index hospitalization (median age 3 months) and at an age 3y exam (R01AI-114552; Camargo, PI). Follow-up data include biannual parent interviews and medical records to age 5 years, with ~90% follow-up to date. This UG3/UH3 application would: 1) extend the largest severe bronchiolitis cohort in the world (e.g., through an age 6y in-person exam to diagnose and phenotype asthma), and 2) build on our local MARC-43 cohort of 120 healthy infants by adding 600 healthy infants from four diverse sites (total n=720). Both cohorts undergo similar procedures (e.g., serial nasal swabs during early childhood). Our overarching hypothesis is that airway Moraxella abundance is associated with increased risk of childhood asthma, and our pilot data are supportive. In Aim 1, we will investigate the relation of the airway microbiome in early infancy to risk of age 6y asthma among infants with severe bronchiolitis (MARC-35). In Aim 2, we will do the same but among healthy infants (MARC-43). In Aim 3, we will investigate the relation of longitudinal patterns of the airway microbiome (e.g., infancy, age 3y, age 6y) to risk of childhood asthma in the two cohorts combined. In a subset of 200 children (100 from each cohort), we will use whole genome shotgun (WGS) sequencing to examine the relations of bacterial species and metabolic potential in early infancy to risk of asthma. For all 3 Aims, we will examine if associations differ by asthma phenotype (e.g., allergic asthma). The investigators are NIH-funded researchers working in an outstanding research environment. The proposed project is innovative and, by providing a strong evidence base for the future development of targeted microbiome interventions, advances research on the primary prevention of asthma. Moreover, the two racially/ethnically-diverse cohorts will provide the ECHO Consortium with comprehensive data on demographics, development, environmental exposures, genetics, and outcomes from two already-harmonized, multicenter U.S. studies.
项目总结/摘要 细支气管炎是美国婴儿住院的头号原因,约有13万例住院 每年。小队列研究(n <210)表明,40 - 50%的婴儿住院与 细支气管炎以后会发展成哮喘。发展小学面临的最大挑战 针对这一大批儿童(实际上是所有儿童)的预防战略是非常早期的, 确定可改变的危险因素和哮喘的异质性。第35届多中心 气道研究协作(MARC-35)研究(U01AI-087881; Camargo,PI)是一项17个中心的研究, 一项前瞻性队列研究,完成了921例毛细支气管炎住院婴儿的入组 2014年在这个多样化的队列(53%的非洲裔美国人或西班牙裔)中,研究人员收集了 生物标本,包括首次住院时的鼻拭子(中位年龄3个月)和 3岁检查(R01AI-114552; Camargo,PI)。随访数据包括一年两次的父母 访谈和医疗记录,直到5岁,到目前为止,随访率约为90%。UG3/UH3 应用将:1)扩展世界上最大的严重细支气管炎群组(例如,通过 年龄6岁的人在现场考试诊断和表型哮喘),和2)建立在我们当地的MARC-43 120名健康婴儿的队列,增加了来自四个不同地点的600名健康婴儿(总n = 720)。 两个队列都经历了类似的程序(例如,儿童早期的连续鼻拭子)。我们 总体假设是,气道莫拉菌丰度与以下风险增加相关: 儿童哮喘,我们的试点数据是支持的。在目标1中,我们将研究 婴幼儿早期气道微生物群与6岁以上重度哮喘患儿发生哮喘风险 细支气管炎(MARC-35)。在目标2中,我们将做同样的事情,但在健康婴儿中(MARC-43)。 在目标3中,我们将研究气道微生物组的纵向模式(例如, 婴儿期、3岁、6岁)与儿童期哮喘风险的关系。的子集中 200名儿童(每个队列100名),我们将使用全基因组鸟枪(WGS)测序, 研究细菌种类和婴儿早期代谢潜力与 哮喘对于所有3个目标,我们将检查是否存在哮喘表型的相关性(例如,过敏 哮喘)。研究人员是NIH资助的研究人员,他们在一项杰出的研究中工作, 环境拟议的项目具有创新性,通过提供强有力的证据基础, 目标微生物组干预措施的未来发展,推进了对主要微生物的研究, 预防哮喘。此外,这两个种族/族裔多样化的群体将提供 ECHO联合会,提供人口、发展、环境 暴露、遗传学和来自两项已经协调的多中心美国研究的结果。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

CARLOS A. CAMARGO其他文献

CARLOS A. CAMARGO的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('CARLOS A. CAMARGO', 18)}}的其他基金

Nasal microRNA during bronchiolitis and age 6y asthma phenotypes: MARC-35 cohort
细支气管炎和 6 岁哮喘表型期间的鼻 microRNA:MARC-35 队列
  • 批准号:
    10267407
  • 财政年份:
    2020
  • 资助金额:
    $ 22.59万
  • 项目类别:
Host genetics, early-life microbiome, and childhood asthma: MARC-43 Boston
宿主遗传学、生命早期微生物组和儿童哮喘:MARC-43 波士顿
  • 批准号:
    10742124
  • 财政年份:
    2016
  • 资助金额:
    $ 22.59万
  • 项目类别:
Nasal microRNA during bronchiolitis and age 6y asthma phenotypes: MARC-35 cohort
细支气管炎和 6 岁哮喘表型期间的鼻 microRNA:MARC-35 队列
  • 批准号:
    9215155
  • 财政年份:
    2016
  • 资助金额:
    $ 22.59万
  • 项目类别:
Airway microbiome and age 6y asthma phenotypes in 2 diverse multicenter cohorts
2 个不同多中心队列中的气道微生物组和 6 岁哮喘表型
  • 批准号:
    10012789
  • 财政年份:
    2016
  • 资助金额:
    $ 22.59万
  • 项目类别:
Nasal microRNA during bronchiolitis and age 6y asthma phenotypes: MARC-35 cohort
细支气管炎和 6 岁哮喘表型期间的鼻 microRNA:MARC-35 队列
  • 批准号:
    10062795
  • 财政年份:
    2016
  • 资助金额:
    $ 22.59万
  • 项目类别:
Comparative Effectiveness Research on Hospital Readmissions for COPD
慢性阻塞性肺病再入院的比较效果研究
  • 批准号:
    9768958
  • 财政年份:
    2015
  • 资助金额:
    $ 22.59万
  • 项目类别:
Comparative Effectiveness Research on Hospital Readmissions for COPD
慢性阻塞性肺病再入院的比较效果研究
  • 批准号:
    8885175
  • 财政年份:
    2015
  • 资助金额:
    $ 22.59万
  • 项目类别:
Comparative Effectiveness Research on Hospital Readmissions for COPD
慢性阻塞性肺病再入院的比较效果研究
  • 批准号:
    9147581
  • 财政年份:
    2015
  • 资助金额:
    $ 22.59万
  • 项目类别:
Comparative Effectiveness Research on Hospital Readmissions for COPD
慢性阻塞性肺病再入院的比较效果研究
  • 批准号:
    9349489
  • 财政年份:
    2015
  • 资助金额:
    $ 22.59万
  • 项目类别:
Infant specific-IgE, rhinovirus-C bronchiolitis, and incident asthma in MARC-35
MARC-35 中的婴儿特异性 IgE、鼻病毒 C 细支气管炎和哮喘事件
  • 批准号:
    9188529
  • 财政年份:
    2014
  • 资助金额:
    $ 22.59万
  • 项目类别:

相似海外基金

Development and social implementation of unified developmental screening for health checkups for 3-year-old children in local governments
地方政府统一开展3岁儿童健康检查发育筛查工作的开展及社会实施
  • 批准号:
    23H01039
  • 财政年份:
    2023
  • 资助金额:
    $ 22.59万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Low vision screening at 3-year-old children's health check-ups: development of a simple and accurate visual acuity testing software
3岁儿童体检中的低视力筛查:开发简单准确的视力测试软件
  • 批准号:
    23K02283
  • 财政年份:
    2023
  • 资助金额:
    $ 22.59万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
0-3-year-old children's language and literacy learning at home in a digital age (0-3s, Tech and Talk)
数字时代0-3岁儿童在家学习语言和识字(0-3s,Tech and Talk)
  • 批准号:
    ES/W001020/1
  • 财政年份:
    2022
  • 资助金额:
    $ 22.59万
  • 项目类别:
    Research Grant
Associations between physical activity levels of mothers and their 1-3 year old children: examining maternal self-efficacy as a mediator
母亲和 1-3 岁孩子体力活动水平之间的关联:检查作为中介的母亲自我效能感
  • 批准号:
    324339
  • 财政年份:
    2015
  • 资助金额:
    $ 22.59万
  • 项目类别:
Lived time of 3-year-old children in early childhood education and care: Reconsidering continuity of life and development
3岁儿童在幼儿教育和保育中的生存时间:重新思考生命和发展的连续性
  • 批准号:
    15K17356
  • 财政年份:
    2015
  • 资助金额:
    $ 22.59万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Development of family support program to form healthy 3-year-old children and their mothers
制定家庭支持计划,培养健康的3岁儿童及其母亲
  • 批准号:
    24593457
  • 财政年份:
    2012
  • 资助金额:
    $ 22.59万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
SUPPORTING 2 AND 3 YEAR OLD PRE-KINDERGARTEN READINESS
支持 2 岁和 3 岁儿童做好学前准备
  • 批准号:
    7699693
  • 财政年份:
    2008
  • 资助金额:
    $ 22.59万
  • 项目类别:
ADENOIDECTOMY FOR OTITIS MEDIA IN 2/3 YEAR OLD CHILDREN
2/3 岁儿童中耳炎的腺切除术
  • 批准号:
    6350559
  • 财政年份:
    1997
  • 资助金额:
    $ 22.59万
  • 项目类别:
EMOTIONAL AND BEHAVIOR PROBLEMS IN 1-3 YEAR OLD CHILDREN
1-3 岁儿童的情绪和行为问题
  • 批准号:
    2890762
  • 财政年份:
    1997
  • 资助金额:
    $ 22.59万
  • 项目类别:
EMOTIONAL AND BEHAVIOR PROBLEMS IN 1-3 YEAR OLD CHILDREN
1-3 岁儿童的情绪和行为问题
  • 批准号:
    2841735
  • 财政年份:
    1997
  • 资助金额:
    $ 22.59万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了