THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A
社区动脉粥样硬化风险 (ARIC) 研究 - 现场中心 - 任务令 01,任务区 A
基本信息
- 批准号:10620985
- 负责人:
- 金额:$ 92.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-11-15 至 2022-11-14
- 项目状态:已结题
- 来源:
- 关键词:AdultAfrican AmericanAmyloid depositionAncillary StudyAreaAtherosclerosisAtherosclerosis Risk in CommunitiesAtrial FibrillationBiochemicalBiological AssayBlood VesselsBlood specimenBrainCandidate Disease GeneCardiovascular DiseasesCase-Control StudiesClinicalCognitionCohort StudiesCollaborationsCommunitiesContractsCoronary heart diseaseCountyCryopreservationDNADataData CollectionDementiaDiabetes MellitusEFRACElectrocardiogramEnvironmental Risk FactorEventFosteringFundingGeneticGenome ScanGeographic LocationsGoalsGrantHeart failureHospitalizationInjuryInvestigationLymphocyteMonitorMyocardial InfarctionNatural HistoryParticipantPoliciesProcessProspective cohort studyPublicationsResearch PersonnelRisk FactorsSubgroupTechnologyUnited States National Institutes of HealthVentricular DysfunctionVital StatusWashingtonagedarterial stiffnessbasecaucasian Americanclinical developmentclinical examinationclinical predictorscohortcoronary artery calcificationdata sharingfollow-upmembermiddle agemortalitynovelpreservationrecruitresidencerural settingsuburbtrend
项目摘要
The Atherosclerosis Risk in Communities (ARIC) Study was initiated in 1985 with two components: community-based surveillance and a prospective cohort study. The community surveillance aimed to monitor trends in hospitalized myocardial infarction (MI), fatal coronary heart disease (CHD) in four U.S. communities: Forsyth County, NC; Jackson, MS; suburbs of Minneapolis, MN; and Washington County, MD. Surveillance for hospitalized heart failure (HF) events was added in 2005. The communities were selected to provide data across four (4) geographic locations with a range of mortality rates, in urban, suburban, and rural settings. The cohort study aimed to investigate the risk factors for and natural history of atherosclerosis and development of clinical atherosclerosis in middle-aged white or African American adults from the same communities. The study recruited in 15,792 white or African American participants initially aged 45-64 years and selected participants received triennial clinical exams over the first ten years of the study (1987-1989, 1990-1992, 1993-1995, and 1996-1998). The clinical exam in 2011-13 was conducted on over 6,500 participants 69-89 years with a focus on characterizing heart failure stages in community-dwelling participants and enabling identification of genetic and environmental factors leading to ventricular dysfunction and vascular stiffness. These data provided the basis for several ancillary studies covering a breadth of topics. The clinical exam in 2018-19 on almost 3,600 participants 75 years and older supported exam components from 12 NIH grant-funded ancillary studies on topics including progression of Heart Failure with preserved Ejection Fraction (HFpEF), coronary artery calcification, atrial fibrillation burden detected by novel continuous ECG monitoring technology, diabetes, dementia, brain amyloid deposition, and changes in arterial stiffness and cognition. Participation of the surviving cohort was 91, 82, 74, 65, and 50% at each of the respective follow-up examinations. Blood samples have been assayed for putative biochemical risk factors and stored for case-control studies. DNA has been extracted and lymphocytes cryopreserved (for possible immortalization) for study of candidate genes, genome-wide scanning, expression, and other –omics investigations. Since baseline, cohort members have also been contacted every 12 months (and every 6 months since 2012) to obtain information on vital status, current residence, major illness or injury, and hospitalizations occurring between contacts to identify clinical cardiovascular disease (CVD) events. Cohort contact was 78% at the last completed follow-up period. Findings have been presented in over 2,600 publications as of 2021.
社区动脉粥样硬化风险(ARIC)研究始于1985年,包括两个部分:社区监测和前瞻性队列研究。社区监测旨在监测美国四个社区住院心肌梗死(MI)、致死性冠心病(CHD)的趋势:北卡罗来纳州福赛斯县;杰克逊女士;明尼阿波利斯郊区,明尼苏达州;2005年增加了住院心力衰竭(HF)事件的监测。这些社区被选中提供四(4)个地理位置的数据,包括城市、郊区和农村的死亡率范围。该队列研究旨在调查来自同一社区的中年白人或非洲裔美国成年人动脉粥样硬化的危险因素、自然病史和临床动脉粥样硬化的发展。该研究招募了15,792名年龄在45-64岁之间的白人或非裔美国人参与者,选定的参与者在研究的前十年(1987-1989年,1990-1992年,1993-1995年和1996-1998年)接受三年一次的临床检查。2011- 2013年的临床研究对6500多名69-89岁的参与者进行了临床研究,重点是描述社区参与者的心力衰竭阶段,并确定导致心室功能障碍和血管僵硬的遗传和环境因素。这些数据为几项涵盖广泛主题的辅助研究提供了基础。2018-19年的临床检查对近3600名75岁及以上的参与者进行了临床检查,支持了来自12项NIH资助的辅助研究的检查内容,这些研究的主题包括心力衰竭的进展并保留射血分数(HFpEF),冠状动脉钙化,新型连续心电图监测技术检测的房颤负担,糖尿病,痴呆,脑淀粉样蛋白沉积,以及动脉僵硬和认知的变化。在每次随访检查中,存活队列的参与率分别为91%、82%、74%、65%和50%。对血液样本进行了假定的生化危险因素分析,并保存以供病例对照研究。DNA已被提取,淋巴细胞冷冻保存(为了可能的永生),用于候选基因的研究,全基因组扫描,表达和其他组学研究。自基线以来,每12个月与队列成员联系一次(自2012年以来每6个月),以获取有关接触者之间的生命状况、当前居住地、主要疾病或损伤以及住院情况的信息,以确定临床心血管疾病(CVD)事件。在最后一个完成的随访期间,队列接触率为78%。截至2021年,研究结果已发表在2600多份出版物上。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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LYNNE WAGENKNECHT其他文献
LYNNE WAGENKNECHT的其他文献
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{{ truncateString('LYNNE WAGENKNECHT', 18)}}的其他基金
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A
社区动脉粥样硬化风险 (ARIC) 研究 - 现场中心 - 任务令 01,任务区 A
- 批准号:
10788259 - 财政年份:2021
- 资助金额:
$ 92.74万 - 项目类别:
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