Precision Brain Health Monitoring for Alzheimer's Disease Risk Detection in the Framingham Study

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Project Summary This supplement seeks to extend the data collection of lens amyloid and smartphone cognitive data to include participants who are Hispanic-Latino/LatinX descent. These data will offset the limited racial/ethnic heterogeneity of the FHS cohort, which is largely non-Hispanic White. The Rio Grande site from which participants will be invited to participate is 99% Hispanic-Latino/LatinX. An estimated 25% of the elderly population in this area are diagnosed with AD dementia and there is concern that this is an underestimate because of income and limited healthcare insurance. The first aim will conduct an ocular scan that provides an Aß biomarker of AD measured in the lens to characterize Aβ burden in a community-based population of Hispanic-Latino/LatinX descent whose age ranges overlap with that of the FHS cohort. The second aim includes using smartphone applications to collect 1 year of longitudinal cognitive metrics from participants who are of Hispanic-Latino/LatinX descent that can be combined with 1 year of longitudinal cognitive metrics from the FHS cohort so that characterization results are more generalizable. Currently the Framingham Heart Study cohort from which the lens amyloid and digital cognitive assessment are to be collected is estimated to be 3,375 of which 131 are projected to be of Hispanic/Latino/LatinX descent. This is well under the 18.7% of the U.S. population that is comprised of people from this ethnic/racial group. To collect data is that is appropriately representative (e.g., 18.7%) will require collecting data from an additional 500 participants from the Rio Grande site.