Supplement

补充

基本信息

  • 批准号:
    10623041
  • 负责人:
  • 金额:
    $ 7.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-15 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

I. SUMMARY OF THE FUNDED PARENT AWARD R01 GM140584 This proposal seeks to understand how proteins located in the cell membrane work as gatekeepers to selectively allow compounds into or out of the cell. Such gatekeepers are known as ATP-binding cassette (ABC) transporters because they use the energy of ATP (adenosine triphosphate) hydrolysis to transport compounds across the cell membrane. Bacterial ABC importers are essential for organism survival, controlling the rate of uptake for nutrients scavenged from the bacterium's environment. Control of the rate of transport precludes over- accumulation of a nutrient that is beneficial at low concentrations but is potentially toxic at high concentrations. While a subset of ABC proteins contain an additional “accessory” domain that can regulate the uptake of compounds by shutting off the transporter, it is unclear why certain transporters contain these domains while others do not. However, we do understand that certain transporters are “turned off” when a specific compound or protein binds to this accessory domain. Other accessory domains regulate by “sensing” changes in the microenvironment and reacting accordingly. To decipher this mechanism of regulation, the PI's laboratory combines biochemical and biophysical experiments with structural biology to understand how these accessory domains play a role in transport regulation, which in restricts or allows nutrients to enter the cell. This research program will define the molecular mechanism that controls nutrient uptake and allow researchers to understand how multiple transport systems work in concert within an organism to maintain cell survival. We will test our hypothesis that regulation of transporter activation via a sensing accessory protein. The proposed research will decipher the complex circuitry of regulation in a model system in three Aims to: (1) understand how PepT SBPs select for different substrates within the microenvironment (i.e., nutrients, cofactors, and peptides); (2) determine how the assembly of the core transporter dictates transport selectivity and efficiency (3) reveal how PepT transporters regulate the import of substrates into the cell through the activation of a novel regulatory domain. This research program has set out to close critical gaps in the understanding of the fundamentals of the transport mechanism present in all bacteria. The results will yield insights into how regulatory domains modulate transport across all organisms, crucial for cell viability. There are no changes to the funded parent award
一、资助父母奖总结r01 gm140584

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Heather Wendy Pinkett其他文献

Heather Wendy Pinkett的其他文献

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{{ truncateString('Heather Wendy Pinkett', 18)}}的其他基金

Molecular Biophysics Training Program at Northwestern University
西北大学分子生物物理学培训项目
  • 批准号:
    10405487
  • 财政年份:
    2021
  • 资助金额:
    $ 7.85万
  • 项目类别:
Molecular Biophysics Training Program at Northwestern University
西北大学分子生物物理学培训项目
  • 批准号:
    10615114
  • 财政年份:
    2021
  • 资助金额:
    $ 7.85万
  • 项目类别:
Regulation mechanisms of ABC transporters
ABC转运蛋白的调控机制
  • 批准号:
    10478032
  • 财政年份:
    2020
  • 资助金额:
    $ 7.85万
  • 项目类别:
A novel multifunctional role of diverse substrate binding and import by the Haemophilus Sap transporter
嗜血杆菌汁液转运蛋白多种底物结合和输入的新型多功能作用
  • 批准号:
    10582420
  • 财政年份:
    2020
  • 资助金额:
    $ 7.85万
  • 项目类别:
Regulation mechanisms of ABC transporters
ABC转运蛋白的调控机制
  • 批准号:
    10682597
  • 财政年份:
    2020
  • 资助金额:
    $ 7.85万
  • 项目类别:
Regulation mechanisms of ABC transporters
ABC转运蛋白的调控机制
  • 批准号:
    10893186
  • 财政年份:
    2020
  • 资助金额:
    $ 7.85万
  • 项目类别:
Regulation mechanisms of ABC transporters
ABC转运蛋白的调控机制
  • 批准号:
    10260611
  • 财政年份:
    2020
  • 资助金额:
    $ 7.85万
  • 项目类别:

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