Clinical Translational Research Center for Neurodevelopmental Disorders
神经发育障碍临床转化研究中心
基本信息
- 批准号:10621066
- 负责人:
- 金额:$ 5.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-28 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:2 year oldAddressAffectAngelman SyndromeApplied ResearchBasic ScienceBlood CirculationBrainCaliberCenter for Translational Science ActivitiesCerebrospinal FluidChildClinicalClinical ResearchClinical SciencesClinical ServicesCollaborationsCommunitiesComplexDataData Science CoreDevelopmentDevelopmental DisabilitiesDiagnosisDisciplineEarly DiagnosisEarly InterventionEnvironmentEtiologyFamilyFosteringFragile X SyndromeFunctional disorderFundingGeneticGenomicsGoalsGrantImpairmentIndividualInfantInstitutesIntellectual and Developmental Disabilities Research CentersIntellectual functioning disabilityInterdisciplinary StudyInterventionLaboratoriesLinkMeningeal lymphatic systemMicroscopyMusNatureNeurodevelopmental DisorderNeurosciencesNorth CarolinaParticipantPathogenesisPathogenicityPersonal SatisfactionPhenotypePlayPreventionPrevention strategyProteinsRattusRegistriesReportingResearchResearch PersonnelResearch Project GrantsResearch SupportResearch TrainingResourcesRoleScienceSyndromeTrainingTranslational ResearchUnited States National Institutes of HealthUniversitiesanimal imagingautism spectrum disorderbasebehavior measurementbehavioral phenotypingbrain behaviorcollaborative environmentcost effectiveeducational atmosphereimaging facilitiesimprovedinsightmouse modelmultidisciplinaryneuroinflammationnovelpre-clinicalpredictive markerprogramsresponsesynergismtargeted treatmenttherapy development
项目摘要
Project Summary
The University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is an
interdisciplinary program with the overarching goal of supporting and promoting research relevant to
understanding the pathogenesis and treatment of neurodevelopmental disorders. The UNC IDDRC is a critical
component of the new Carolina Institute for Developmental Disabilities (CIDD), which is the focal point for
clinical services, research, and training relevant to intellectual and developmental disabilities (IDDs) on the
UNC campus. The UNC IDDRC currently supports 46 investigators from 13 University departments, and
includes 89 externally-funded research projects. The broad-based research program of this IDDRC is
integrated around 3 themes: (1) Brain and Behavior Development; (2) Autism and Related
Neurodevelopmental Disorders; and, (3) Early Detection/Intervention. The UNC IDDRC is a highly
collaborative program highlighted by the presence of several NIH-funded, interdisciplinary research
centers/programs. This application seeks support for: (1) an Administrative Core; (2) three research cores –
the Clinical Translational Core, which includes the Research Participant Registry and Brain-Behavior
Measurement Laboratory; the PreClinical Core, which includes the Mouse Behavioral Phenotyping Laboratory,
Neuroscience Microscopy Facility, and Small Animal Imaging Facility; the Data Science Core Core; and (3) a
pre-clinical/clinical research project entitled “Cerebrospinal fluid abnormalities in neurodevelopmental
disorders” that proposes to examine role of CSF pathophysiology in the pathogenesis of selected
neurodevelopmental disorders. The three proposed research cores provide cutting-edge, high-quality and cost
effective support for this integrated, multidisciplinary, translational program of IDD-relevant research. Overall,
this Center has had a major impact on developmental disabilities research and scientific training at the
University of North Carolina, and renewal would allow us to continue our support of the truly exceptional
program of IDD research conducted at UNC.
项目摘要
北卡罗来纳大学智力与发展障碍研究中心(IDDRC)
跨学科计划,主要目标是支持和促进与以下领域相关的研究
了解神经发育障碍的发病机制和治疗。北卡罗来纳大学国际数据发展中心是一个关键
新的卡罗莱纳发育障碍研究所(CIDD)的组成部分,它是
与智力和发育障碍(IDDS)相关的临床服务、研究和培训
北卡罗来纳大学校园。北卡罗来纳大学国际发展研究中心目前支持来自13个大学系的46名调查人员,以及
包括89个外部资助的研究项目。IDDRC的基础广泛的研究计划是
围绕三个主题整合:(1)大脑和行为发展;(2)自闭症及其相关
神经发育障碍;以及(3)早期发现/干预。北卡罗来纳大学国际数据中心是一个高度
几项由美国国立卫生研究院资助的跨学科研究突出了合作计划
中心/项目。本申请寻求支持:(1)行政核心;(2)三个研究核心-
临床翻译核心,包括研究参与者注册和大脑行为
测量实验室;临床前核心,包括小鼠行为表型实验室,
神经科学显微镜设备和小动物成像设备;数据科学核心;以及(3)
《神经发育中的脑脊液异常》临床前/临床研究项目
疾病“,建议研究脑脊液病理生理学在所选疾病发病中的作用
神经发育障碍。拟议的三个研究核心提供尖端、高质量和低成本
有效地支持这一综合的、多学科的、与IDD相关的研究的翻译计划。总的来说,
该中心在发展性残疾研究和科学培训方面产生了重大影响
北卡罗来纳大学,续签将使我们能够继续支持真正特殊的
北卡罗来纳大学开展的IDD研究计划。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('GABRIEL S DICHTER', 18)}}的其他基金
Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis
检查雌二醇对围绝经期快感缺失和精神病患者奖励的神经和分子反应的影响
- 批准号:
10544325 - 财政年份:2022
- 资助金额:
$ 5.55万 - 项目类别:
Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis
检查雌二醇对围绝经期快感缺失和精神病患者奖励的神经和分子反应的影响
- 批准号:
10348271 - 财政年份:2022
- 资助金额:
$ 5.55万 - 项目类别:
Clinical Translational Research Center for Neurodevelopmental Disorders
神经发育障碍临床转化研究中心
- 批准号:
10455486 - 财政年份:2020
- 资助金额:
$ 5.55万 - 项目类别:
Clinical Translational Research Center for Neurodevelopmental Disorders
神经发育障碍临床转化研究中心
- 批准号:
10673835 - 财政年份:2020
- 资助金额:
$ 5.55万 - 项目类别:
Development of A Novel Transdiagnostic Intervention for Anhedonia
开发一种针对快感缺失的新型跨诊断干预措施
- 批准号:
10224009 - 财政年份:2017
- 资助金额:
$ 5.55万 - 项目类别:
Neural Circuits That Regulate Social Motivation in Autism
调节自闭症社交动机的神经回路
- 批准号:
9296174 - 财政年份:2017
- 资助金额:
$ 5.55万 - 项目类别:
Development of A Novel Transdiagnostic Intervention for Anhedonia
开发一种针对快感缺失的新型跨诊断干预措施
- 批准号:
9456980 - 财政年份:2017
- 资助金额:
$ 5.55万 - 项目类别:
Development of A Novel Transdiagnostic Intervention for Anhedonia
开发一种针对快感缺失的新型跨诊断干预措施
- 批准号:
9795076 - 财政年份:2017
- 资助金额:
$ 5.55万 - 项目类别:
A Simultaneous PET/MR Study of Striatal Dopamine Binding in Autism
自闭症纹状体多巴胺结合的同时 PET/MR 研究
- 批准号:
9245385 - 财政年份:2016
- 资助金额:
$ 5.55万 - 项目类别:
Imaging Genetic Predictors of Psychotherapy Outcomes in Unipolar Depression
单相抑郁症心理治疗结果的影像遗传预测因子
- 批准号:
8456070 - 财政年份:2012
- 资助金额:
$ 5.55万 - 项目类别:
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