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Gluconeogenic control of Dravet Syndrome

Gluconeogenic control of Dravet Syndrome
Dravet 综合征的糖异生控制
批准号：
10624665
负责人：
Scott C Baraban
金额：
$15.89万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
未结题
起止时间：
2020-06-01 至 2025-05-31
来源：
https://reporter.nih.gov/project-details/10624665
关键词：
Administrative SupplementBiological AssayChildhoodDefectDiseaseDisease modelEpilepsyGeneticGenus HippocampusGoalsLarvaMeasuresMetabolicMitochondriaModelingPathway interactionsResearchSeizuresTechnologyTimeZebrafishbehavioral impairmentdravet syndromeextracellularinnovationinsightinstrumentmetabolic abnormality assessmentnovelparent project

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英文摘要
The goal of this administrative supplement is to request the purchase of a critical instrument (Seahorse XF24e, Agilent Technologies) which is necessary for the continuation and completion of the project. To achieve the major aims and goals of the parent project are to study metabolic defects in a devastating neurodevelopmental disease known as Dravet Syndrome. A key assay that we have developed for this project is assessment of metabolic defects in a zebrafish model of the disease. The assay involves the use of an extracellular flux analyzer that measures mitochondrial and glycolytic functions in real time in live zebrafish larvae. The instrument is requested to replace a new version of a previous model which has been retired by the company.
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Gluconeogenic control of Dravet Syndrome
  • 批准号：
    10415061
  • 项目类别：
  • 资助金额：
    $46.32万
  • 财政年份：
    2020
  • 负责人：
    Scott C Baraban
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
Gluconeogenic control of Dravet Syndrome
  • 批准号：
    10159955
  • 项目类别：
  • 资助金额：
    $46.88万
  • 财政年份：
    2020
  • 负责人：
    Scott C Baraban
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
Gluconeogenic control of Dravet Syndrome
  • 批准号：
    10626920
  • 项目类别：
  • 资助金额：
    $45.73万
  • 财政年份：
    2020
  • 负责人：
    Scott C Baraban
  • 依托单位：
    UNIVERSITY OF COLORADO DENVER
Functional evaluation of catastrophic childhood epilepsy genes in zebrafish
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