Supplemental: Improving Inference of Genetic Architecture and Selection with African Genomes
Supplemental: Improving Inference of Genetic Architecture and Selection with African Genomes
批准号:
10622156
负责人:
Brenna M Henn
金额:
$7.66万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-05 至 2024-07-31
关键词:
AfricanAfrican American populationAnimal ModelBiological AssayBiological ModelsCandidate Disease GeneCase StudyClustered Regularly Interspaced Short Palindromic RepeatsCollectionCommunitiesComplexDNAEtiologyEuropeanFishesGenesGeneticGenetic DeterminismGenetic RecombinationGenomeGenomicsGenotypeGrantHeightHeritabilityHumanImageIndividualKnock-outLarvaMapsMeasuresMethodsMindModelingMosaicismMutationNamibiaOutcomeParentsPatternPhenotypePigmentation physiologic functionPopulationResearchResourcesSNP arraySample SizeSamplingSiblingsSiteSkin PigmentationSouth AfricaSouthern AfricaSystemTestingVariantWorkZebrafishcausal variantcohortdensitydisease phenotypeexperiencegene discoverygenetic architecturegenetic pedigreegenetic selectiongenetic variantgenome wide association studyhutteriteimprovedknockout genenovelparent grantphenotypic dataportabilityprogramsskin colortrait
中文摘要
项目摘要
迫切需要在小规模、多样化的群体中进行人口基因组研究,
遗传学家描述任何人类社区疾病/表型的遗传决定因素。
最近提出了各种新的复杂性状定位方法,用于内婚或
混合种群然而,这些方法往往是与特定的欧洲血统,
考虑到案例研究(例如,在赫特人,撒丁岛)和应用到替代队列介绍
特别是在非洲大陆和非洲裔美国人群体中。
我的实验室专门研究非洲的基因组多样性,
在南部非洲发展群组收集。为了验证关于遗传结构的假设,
在非洲群体中的多基因选择模式,我专注于高度遗传,易于测量的性状
[e.g.身高,皮肤色素沉着]作为模型系统,用于识别基因型-表型关联。
例如,我们已经证明,非洲人的色素沉着的多源性要复杂得多
比欧洲人。虽然野外工作是我实验室研究计划的核心,但它也提供了一个至关重要的
其他研究小组的基因组资源。南部非洲人,如KhoeSan人,
在其他地方很少观察到的变异及其不寻常的连锁不平衡模式,
用于精细绘制因果变异。这项赠款的成果将包括:1)收集DNA,
实地考察,并为我们的实验室描述南部非洲人群的基本基因组特征
和合作者; 2)估计重组率和突变模式在南部非洲使用
深谱系; 3)使用皮肤色素沉着和身高作为模型,以了解便携性
基因型-表型的相关性。
英文摘要
Project Summary
There is a pressing need for population genomic research in small, diverse cohorts -- allowing
geneticists to characterize the genetic determinants of disease/phenotype for any human community.
A variety of new complex trait mapping methods have been recently proposed for endogamous or
admixed populations. However, these methods were often developed with specific European-descent
case-studies in mind (e.g. in Hutterites, Sardinians) and application to alternative cohorts introduces
special challenges, especially in continental African and African-American populations.
My lab specializes in African genomic diversity and I have over 13 years experience
developing cohort collections in southern Africa. To test hypotheses about genetic architecture and
polygenic selection patterns in African cohorts, I focus on highly heritable, easily measured traits
[e.g. height, skin pigmentation] as model systems for identifying genotype-phenotype associations.
We have shown, for example, that the polygenicity of pigmentation is far more complex in Africans
than in Europeans. While field work is central to my lab's research program, it also provides a crucial
genomic resource for other research groups. Southern Africans, like the KhoeSan, contain genetic
variants which are rarely observed elsewhere and their unusual patterns of linkage disequilbrium can
be used to fine-map causal variants. Outcomes of this grant will include: 1) collect DNA, maintain
field sites and characterize fundamental genomic features of southern African populations for our lab
and collaborators; 2) estimate recombination rates and mutational patterns in southern Africans using
deep pedigrees; 3) use skin pigmentation and height as models for understanding the portability of
genotype-phenotype associations across populations.
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会议论文
Administrative Supplement: Improving Inference of Genetic Architecture and Selection with African Genomes
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批准号:10891050
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项目类别:
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资助金额:$11.16万
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财政年份:2023
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负责人:Brenna M Henn
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依托单位:
Improving Inference of Genetic Architecture and Selection with African Genomes
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批准号:10226849
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项目类别:
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资助金额:$38.4万
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财政年份:2019
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负责人:Brenna M Henn
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依托单位:
Improving Inference of Genetic Architecture and Selection with African Genomes
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批准号:9797610
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项目类别:
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资助金额:$38.4万
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财政年份:2019
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负责人:Brenna M Henn
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依托单位:
Improving Inference of Genetic Architecture and Selection with African Genomes
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批准号:10009451
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项目类别:
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资助金额:$38.12万
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财政年份:2019
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负责人:Brenna M Henn
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依托单位:
Improving Inference of Genetic Architecture and Selection with African Genomes
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批准号:10439682
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项目类别:
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资助金额:$38.23万
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财政年份:2019
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负责人:Brenna M Henn
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依托单位:
Improving Inference of Genetic Architecture and Selection with African Genomes
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批准号:10726904
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项目类别:
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资助金额:$8.17万
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财政年份:2019
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负责人:Brenna M Henn
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依托单位:
Improving Inference of Genetic Architecture and Selection with African Genomes
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批准号:10661519
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项目类别:
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资助金额:$37.71万
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财政年份:2019
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负责人:Brenna M Henn
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依托单位:
Supplement: Improving Inference of Genetic Architecture and Selection with African Genomes
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批准号:10389999
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项目类别:
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资助金额:$8.5万
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财政年份:2019
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负责人:Brenna M Henn
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依托单位:
海外基金