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Cognitive Motor Interference Assessment for Improving Neurologic and Physical Disability Outcomes in Survivors of Severe Acute Respiratory Failure (CAMINANDO) Phase II

用于改善严重急性呼吸衰竭幸存者的神经系统和身体残疾结果的认知运动干扰评估 (CAMINANDO) 第二阶段

基本信息

批准号：
10621635
负责人：
Aluko A. Hope
金额：
$ 17.66万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2024-08-31
项目状态：
已结题

项目摘要

Project Summary/Abstract Severe acute respiratory failure is the most common organ failure in the intensive care unit, the most severe form of which is acute respiratory failure syndrome. Understanding and preventing the long-term physical and cognitive impairments that is the legacy of surviving acute respiratory failure (ARF) is the career goal of this junior minority investigator with previous clinical training in Pulmonary, Critical Care and research training in Clinical Epidemiology. Although previous research in ARF has examined mobility outcomes independently from the cognitive outcomes, emerging evidence suggests that mobility and cognitive outcomes are intertwined. Cognitive Motor Interference (CMI) is an emerging risk assessment and treatment approach for improving disability outcomes in many patient populations. Dr. Hope describes a mentored research project and specific career development plan which will enable him to become an expert in CMI assessments in patients with acute respiratory failure. The research proposal aims to leverage the NHLBI funded Prevention and Early Treatment of Acute Lung Injury (PETAL) network to define the scope, pattern and predictive validity of assessing acute respiratory failure patients for CMI while in the hospital. The research proposal's second aim is to conduct a single-center randomized clinical trial of hospital based CMI-based training in acute respiratory failure patients. During the award period, Dr. Hope has developed a structured plan to build on his previous training by attaining skills in four additional areas: 1) measuring cognitive motor interference in acutely ill patients; 2) understanding and intervening on disability outcomes after critical illness; 3) the management of clinical trials and 4) structured equation modeling. As part of this career development award, Dr. Hope will be a co-Principal Investigator for PETAL network studies at his institution and will serve as site Principal Investigator for an NHLBI funded ancillary study called PRIMROSE. As a member of the PETAL Network Long-Term Outcomes Working Group Committee, he will be involved, along with his mentors and collaborators, with developing recommendations for measuring long-term outcomes in the PETAL network studies. Dr. Hope will work closely with co-mentors in Neurology, Geriatrics and Critical Care with expertise in cognitive and mobility outcomes; He will also work with advisors and collaborators in Rehabilitation Medicine with expertise in the disability process in acutely ill patients. Through a mix of formal and informal coursework, practical experience, local and international meetings along with directed feedback from this multi-disciplinary team of mentors and advisors, Dr. Hope will be prepared to become an independent investigator by the end of this award period.

项目总结/摘要严重急性呼吸衰竭是重症监护病房最常见的器官衰竭，急性呼吸衰竭综合征的一种形式。了解和预防长期的身体和认知障碍是生存急性呼吸衰竭（ARF）的遗产，这是其职业目标。初级少数民族研究者，既往接受过肺部、重症监护和研究培训，临床流行病学。尽管之前的ARF研究独立地检查了移动性结果从认知结果来看，新出现的证据表明，交织在一起认知运动干扰（CMI）是一种新兴的风险评估和治疗方法，改善许多患者群体的残疾结局。霍普博士描述了一个受指导的研究项目和具体的职业发展计划，使他能够成为一个专家，在CMI评估，急性呼吸衰竭患者。该研究提案旨在利用NHLBI资助的预防和急性肺损伤早期治疗（PETAL）网络，以确定范围、模式和预测有效性评估急性呼吸衰竭患者的CMI。研究计划的第二部分目的是进行一项单中心随机临床试验，以医院为基础，以CMI为基础的培训，在急性呼吸衰竭患者。在获奖期间，霍普博士制定了一个结构化的计划，通过获得四个额外领域的技能来进行先前的培训：1）测量急性认知运动干扰，疾病患者; 2）了解和干预危重病后的残疾结果; 3）管理临床试验和4）结构方程建模。作为职业发展奖的一部分，霍普博士将成为一名其所在机构PETAL网络研究的共同主要研究者，并将担任研究中心主要研究者一项名为报春花的NHLBI资助的辅助研究。作为PETAL长期网络的成员成果工作组委员会，他将沿着他的导师和合作者，为衡量PETAL网络研究的长期成果提出建议。霍普医生会与神经病学、老年病学和重症监护领域的共同导师密切合作，他们具有认知和移动方面的专业知识结果;他还将与康复医学领域的顾问和合作者合作，急性病患者的残疾过程。通过正式和非正式的课程，实践经验，本地和国际会议沿着来自这个多学科导师团队的直接反馈，顾问，希望博士将准备成为一个独立的研究员，在此奖励期结束。