Cognitive-Motor Interference Assessment for Improving Neurologic and Physical Disability Outcomes (CAMINANDO) in Survivors of Severe Acute Respiratory Failure

项目摘要/摘要 严重急性呼吸衰竭是重症监护室中最常见的器官衰竭，也是最严重的 其形式是急性呼吸衰竭综合征。了解和预防长期的身体和精神疾病 认知障碍是在急性呼吸衰竭(Arf)中存活下来的后遗症，这是他们的职业目标。 曾接受过肺部、重症监护和研究培训的初级少数民族调查员 临床流行病学。尽管之前在ARF上的研究已经独立地检查了移动性结果 从认知结果来看，新出现的证据表明，移动性和认知结果 交织在一起。认知运动干扰(CMI)是一种新兴的风险评估和治疗方法 改善许多患者群体的残疾结果。霍普博士描述了一个有指导的研究项目 和具体的职业发展计划，使他成为CMI评估方面的专家 患有急性呼吸衰竭的患者。这项研究提案旨在利用NHLBI资助的预防 和早期治疗急性肺损伤(花瓣)网络，以确定范围、模式和预测有效性 在住院期间评估急性呼吸衰竭患者的CMI。这项研究提案的第二个 目的是进行一项以医院为基础的以CMI为基础的训练的单中心随机临床试验 呼吸衰竭患者。在颁奖期间，霍普博士制定了一个结构化的计划，以建立在他的 以前的培训，通过获得四个额外领域的技能：1)敏锐地测量认知运动干扰 病人；2)对危重疾病后残疾结局的了解和干预；3)管理 临床试验和4)结构方程建模。作为职业发展奖的一部分，霍普博士将成为 在他的机构担任花瓣网络研究的联合首席调查员，并将担任现场首席调查员 NHLBI资助的一项名为报春花的辅助研究。作为长期花瓣网络的一员 结果工作组委员会，他将与他的导师和合作者一起参与 为衡量PEATAL网络研究的长期结果提出建议。霍普博士会 与神经学、老年病学和重症监护领域的合作导师密切合作，具备认知和行动能力方面的专业知识 结果；他还将与康复医学的顾问和合作者合作，拥有 急症患者的残疾过程。通过正式和非正式课程的混合，实践经验， 本地和国际会议，以及来自这个由导师和 顾问们，霍普博士将准备在本颁奖期结束前成为一名独立调查员。

Project Summary/Abstract Severe acute respiratory failure is the most common organ failure in the intensive care unit, the most severe form of which is acute respiratory failure syndrome. Understanding and preventing the long-term physical and cognitive impairments that is the legacy of surviving acute respiratory failure (ARF) is the career goal of this junior minority investigator with previous clinical training in Pulmonary, Critical Care and research training in Clinical Epidemiology. Although previous research in ARF has examined mobility outcomes independently from the cognitive outcomes, emerging evidence suggests that mobility and cognitive outcomes are intertwined. Cognitive Motor Interference (CMI) is an emerging risk assessment and treatment approach for improving disability outcomes in many patient populations. Dr. Hope describes a mentored research project and specific career development plan which will enable him to become an expert in CMI assessments in patients with acute respiratory failure. The research proposal aims to leverage the NHLBI funded Prevention and Early Treatment of Acute Lung Injury (PETAL) network to define the scope, pattern and predictive validity of assessing acute respiratory failure patients for CMI while in the hospital. The research proposal's second aim is to conduct a single-center randomized clinical trial of hospital based CMI-based training in acute respiratory failure patients. During the award period, Dr. Hope has developed a structured plan to build on his previous training by attaining skills in four additional areas: 1) measuring cognitive motor interference in acutely ill patients; 2) understanding and intervening on disability outcomes after critical illness; 3) the management of clinical trials and 4) structured equation modeling. As part of this career development award, Dr. Hope will be a co-Principal Investigator for PETAL network studies at his institution and will serve as site Principal Investigator for an NHLBI funded ancillary study called PRIMROSE. As a member of the PETAL Network Long-Term Outcomes Working Group Committee, he will be involved, along with his mentors and collaborators, with developing recommendations for measuring long-term outcomes in the PETAL network studies. Dr. Hope will work closely with co-mentors in Neurology, Geriatrics and Critical Care with expertise in cognitive and mobility outcomes; He will also work with advisors and collaborators in Rehabilitation Medicine with expertise in the disability process in acutely ill patients. Through a mix of formal and informal coursework, practical experience, local and international meetings along with directed feedback from this multi-disciplinary team of mentors and advisors, Dr. Hope will be prepared to become an independent investigator by the end of this award period.