Strategies to Innovate EmeRgENcy Care Clinical Trials Network ("SIREN") - Supplement

项目摘要和摘要 本附录请求对关键个人的努力提供支持，使该大学能够 匹兹堡创新紧急护理临床试验网络战略网站(SIREN) 继续作为招募参与者参与急救研究的中心运营。 请求提供补充支助，以维持经常供资结束之间的业务活动 第一个5年的警报期和第二个5年的警报期。不间断的支持 中心的工作将确保参与者成功地参加正在进行的警报器试验； 冰盖、Boost-3和PEDS-ICECAP。我们会继续支持有关的附属研究 这些试验：PRECICECAP，Bio-Boost和Electronics-Boost。我们的具体目标仍然是：1. 为快速实施和登记急诊临床试验提供管理结构 治疗。2.最大限度地减少多中心临床试验的时间、成本和监管障碍 紧急设置。3.探索创新战略，增加识别、招聘和 在紧急治疗试验中同意。4.探索提高环境质量的创新战略 紧急护理数据，并确保保留在紧急情况下登记的受试者。

Project Summary and Abstract This supplement requests support of effort for key individuals that will allow the University of Pittsburgh site for the Strategies to Innovate Emergency Care Clinical Trials Network (SIREN) to continue operations as a Hub for recruiting participants into emergency care research. Supplemental support is requested to maintain operations between the end of regular funding for the first 5 years of SIREN and start of the second 5 years of SIREN. Uninterrupted support of the Hub will ensure successful enrollment of participants into the ongoing SIREN trials; ICECAP, BOOST-3, and Peds-ICECAP. We will continue to support the ancillary studies for these trials: PRECICECAP, Bio-BOOST and electro-BOOST. Our specific Aims remain: 1. Provide administrative structure to rapidly implement and enroll in clinical trials of emergency treatments. 2. Minimize time, cost and regulatory barriers to multicenter clinical trials in emergency settings. 3. Explore innovative strategies to increase identification, recruitment, and consent in emergency treatment trials. 4. Explore innovative strategies to increase quality of emergency care data and to ensure retention of subjects enrolled in emergency settings.