Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN)

辛辛那提大学(UC)中心和分支系统结合了三个地区性学术机构的优势 卫生中心(AHC)和几家社区医院提供强大且易于访问的基础设施 用于在各种紧急适应症中快速实施和高质量地执行临床试验。 我们的机构和我们的合作伙伴在以下方面拥有出色的急性临床试验业绩 院前、急诊科(ED)、医院楼层和重症监护病房(ICU)环境。我们的 中心辐射式系统在有效的临床试验登记和高效的 遵守协议的做法。UC将作为我们网络的管理中心。我们的AHC发言人在 肯塔基大学和路易斯维尔大学将扩大我们对急性疾病和受伤患者的覆盖范围， SIREN网络将受益于其现有的研究基础设施。独特的患者群体 AHC的辐条将由我们的社区医院辐条补充；我们与这些 社区医院在辛辛那提有着既定的成功记录。此外，警报器 目标独特地与加州大学的机构、临床和翻译科学奖(CTSA)保持一致 目标，特别是我们的急性护理研究理事会；这个理事会的目标是建立一个协调的急性护理 覆盖整个地区的研究计划。我们领导团队的专长包括院前护理， 紧急心脏护理、紧急神经护理和创伤/危重护理。我们的首要目标是 将更多的参与者吸引到警报网；我们将为SEREN网络的增长和 通过与其他系统的沟通和协作来最大限度地提高警报器的有效性 整个网络的一部分。

The University of Cincinnati (UC) Hub and Spoke System combines the strengths of three regional academic health centers (AHC) and several community hospitals to provide a robust and readily accessible infrastructure for rapid implementation and high quality performance of clinical trials in a breadth of emergency indications. Our institution and our partners have a strong history of outstanding acute clinical trial performance spanning the prehospital, emergency department (ED), hospital floor and intensive care unit (ICU) environments. Our Hub and Spoke System has a proven history of effective clinical trial enrollments combined with efficient protocol adherent practices. UC will serve as the administrative Hub for our network. Our AHC spokes at University of Kentucky and University of Louisville will expand our catchment of acutely ill and injured patients, and the SIREN Network will benefit from their existing research infrastructures. The unique patient populations of the AHC spokes will be complemented by our community hospital spokes; our partnership with these community hospitals has an established track record of success in Cincinnati. Furthermore, the SIREN objectives uniquely align with UC’s institutional and Clinical and Translational Science Award (CTSA) objectives, especially our Acute Care Research Council; this Council aims to build a coordinated acute care research program that covers the entire region. Expertise of our leadership team include prehospital care, emergency cardiac care, emergency neurological care, and trauma/critical care. Our overarching goal is to bring more than just participants to the SIREN Network; we will meaningfully contribute to the growth and success of SIREN through communication and collaboration with other systems to maximize the effectiveness of the entire network.