Infralimbic circuit control over a sex-dependent switch in threat responding
边缘下电路控制威胁响应中的性别依赖性开关
基本信息
- 批准号:10620853
- 负责人:
- 金额:$ 44.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:Amygdaloid structureAnatomyAnimal ExperimentationAversive StimulusBehaviorBehavioralClinicalComplexConditioned ReflexCreteDataDevelopmentDiseaseDisease susceptibilityDorsalEquilibriumExhibitsExtinctionFOS geneFemaleFreezingFrightGeneticGoalsImmunofluorescence ImmunologicIndividual DifferencesInvestigationLearningLinkMachine LearningMeasuresMediatingMediatorMental disordersModelingNeurobiologyOdorsOutcomeOutcome MeasurePainPatternPerformancePhenotypePost-Traumatic Stress DisordersPre-Clinical ModelPrediction of Response to TherapyPrevalenceRattusRisk FactorsRisk MarkerRoleSex DifferencesShockStimulusStressSynapsesTechniquesTestingViralWomanWorkbehavioral outcomebehavioral responsecohortconditioned fearconditioningcopingdisorder riskflexibilitygenetic approachimprovedinsightmachine visionmalemenmidbrain central gray substanceneuralneural circuitneurobiological mechanismnovelpharmacologicpostsynapticpre-clinicalpredictive markerpreventrecruitresilienceresponseselective expressionsexsexual dimorphismstress resiliencesuccesstooltranslational goaltranslational neurosciencetrauma exposure
项目摘要
Project Summary
Sex differences in the development and prevalence of mental illnesses are widespread, suggesting that the
factors that promote disease risk and resilience may be distinct in men and women. The neurobiological
mechanisms underlying this possibility are poorly understood, however, because the vast majority of pre-
clinical animal research has been conducted in males. In addition, the behavioral outcome measures used to
understand learned fear have focused predominantly on passive, or freezing behavior. We recently identified
an active, escape-like conditioned fear response in rats (“darting”) that occurred almost exclusively in females
and was predictive of improved extinction retention. A better understanding of potentially sexually dimorphic
mechanisms that drive this behavior could open new avenues for treatment of disorders that are more
prevalent in women, like PTSD. We propose here to define the neural circuitry that drives the selection of
conditioned darting vs. freezing, and how that integrates with known extinction circuits to promote extinction
retention. Our preliminary data implicate the infralimbic cortex (IL) in this role, and we will use pharmacological,
chemogenetic, and viral techniques to probe how descending IL projections to the dorsal and ventral
periaqueductal gray (PAG) may mediate a strategic switch between active and passive responding and drive
long-term behavioral flexibility through putative collaterals in the amygdala. We will then use sophisticated
machine vision and machine learning-based tools to define the broader behavioral repertoires within which
darting exists, thereby identifying a multifaceted phenotype that could provide insight into the mechanisms
underlying individual differences in stress resilience and vulnerability.
项目总结
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Darting across space and time: parametric modulators of sex-biased conditioned fear responses.
- DOI:10.1101/lm.053587.122
- 发表时间:2022-07
- 期刊:
- 影响因子:2
- 作者:Mitchell, Julia R.;Trettel, Sean G.;Li, Anna J.;Wasielewski, Sierra;Huckleberry, Kylie A.;Fanikos, Michaela;Golden, Emily;Laine, Mikaela A.;Shansky, Rebecca M.
- 通讯作者:Shansky, Rebecca M.
Sounding the Alarm: Sex Differences in Rat Ultrasonic Vocalizations during Pavlovian Fear Conditioning and Extinction.
- DOI:10.1523/eneuro.0382-22.2022
- 发表时间:2022-11-01
- 期刊:
- 影响因子:3.4
- 作者:Laine, Mikaela A;Mitchell, Julia R;Shansky, Rebecca M
- 通讯作者:Shansky, Rebecca M
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REBECCA M SHANSKY其他文献
REBECCA M SHANSKY的其他文献
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{{ truncateString('REBECCA M SHANSKY', 18)}}的其他基金
Sex-dependent pain processing circuitry in classical Pavlovian fear conditioning
经典巴甫洛夫恐惧调节中的性别依赖性疼痛处理电路
- 批准号:
10572183 - 财政年份:2022
- 资助金额:
$ 44.53万 - 项目类别:
Infralimbic circuit control over a sex-dependent switch in threat responding
边缘下电路控制威胁响应中的性别依赖性开关
- 批准号:
10425352 - 财政年份:2020
- 资助金额:
$ 44.53万 - 项目类别:
Infralimbic circuit control over a sex-dependent switch in threat responding
边缘下电路控制威胁响应中的性别依赖性开关
- 批准号:
10033671 - 财政年份:2020
- 资助金额:
$ 44.53万 - 项目类别:
Infralimbic circuit control over a sex-dependent switch in threat responding
边缘下电路控制威胁响应中的性别依赖性开关
- 批准号:
10223137 - 财政年份:2020
- 资助金额:
$ 44.53万 - 项目类别:
TRPV1 signaling as a sex-specific mechanism of contextual fear generalization
TRPV1 信号传导作为情境恐惧泛化的性别特异性机制
- 批准号:
10091528 - 财政年份:2020
- 资助金额:
$ 44.53万 - 项目类别:
Mapping mesocortical contributions to estrous-dependent learning processes
绘制中皮质对发情依赖性学习过程的贡献
- 批准号:
9807686 - 财政年份:2019
- 资助金额:
$ 44.53万 - 项目类别:
Sex Specific Neuroanatomical Markers Of Vulnerability In Animal Model Of PTSD
PTSD 动物模型中易受伤害的性别特异性神经解剖学标记
- 批准号:
8490449 - 财政年份:2012
- 资助金额:
$ 44.53万 - 项目类别:
Sex Specific Neuroanatomical Markers Of Vulnerability In Animal Model Of PTSD
PTSD 动物模型中易受伤害的性别特异性神经解剖学标记
- 批准号:
8354858 - 财政年份:2012
- 资助金额:
$ 44.53万 - 项目类别:
Sex differences in stress-induced dendritic remodeling
应激诱导的树突重塑的性别差异
- 批准号:
7221343 - 财政年份:2006
- 资助金额:
$ 44.53万 - 项目类别:
Sex differences in stress-induced dendritic remodeling
应激诱导的树突重塑的性别差异
- 批准号:
7294933 - 财政年份:2006
- 资助金额:
$ 44.53万 - 项目类别:
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