Training Program in Precision Genetics of Aging, Alzheimer's Disease and Related Dementias

衰老、阿尔茨海默病和相关痴呆症精准遗传学培训项目

• 批准号: 10621316
• 负责人: Gareth R Howell
• 金额: $ 25.59万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621316
• 关键词: Aging; Alzheimer' s disease related dementia; Training Programs; precision genetics

PROJECT SUMMARY/ABSTRACT The Jackson Laboratory (JAX) has been a leader in mammalian genetics research and education since its inception in 1929. JAX pioneered the development of genetic approaches toward understanding fundamental questions in mammalian development and the genetic underpinnings of human disease. JAX also has a long and illustrious track record of training postdoctoral, and more recently predoctoral scholars, to be productive researchers at the nexus of systems genetics, genomics and computational biology. To support JAX's dual mission of discovery and education, we continually strive to provide cutting-edge, unique, and highly relevant training opportunities designed to prepare all JAX trainees for successful scientific careers. An NIA T32–funded Training Program in Precision Genetics of Aging and Dementia (PGAD) would provide high-quality graduate and postdoctoral training to prepare its trainees for careers as independent investigators in universities, research institutions and the biomedical industry. It would bring together 16 highly productive and well-funded faculty mentors at the JAX Mammalian Genetics campus in Bar Harbor, ME and the JAX Genomic Medicine campus in Farmington, CT who provide a uniquely interdisciplinary, integrated and comprehensive training environment. Research foci within the context of aging and age-related disease include mammalian genetics, hematology, vascular biology, immunology, nephrology, neurology, behavior, microbiome, systems genetics, and bioinformatics. We seek to provide two slots for postdoctoral fellows, and request support for two predoctoral students. JAX participates in collaborative Ph.D. training programs with the Tufts School of Medicine, the University of Maine, and the University of Connecticut that have grown to critical mass. Specific criteria are used to admit both pre- and postdoctoral trainees into the program. Required and elective curricula have been developed to enrich the training experience. Trainees will test hypotheses regarding the genetic underpinnings of aging and disease, and will model new diagnostic and therapeutic modalities, using cutting-edge computational and mouse genetics resources uniquely available to them at JAX. Trainees will have access to focused and individualized career development opportunities, such as teaching and grant writing experiences, and will be integrated into seminars, workshops, and research interest groups. They will write external funding applications, present their findings at scientific meetings, and publish in peer-reviewed journals. Trainee evaluation will be rigorous and coupled with support for growth. The program will thus provide exceptional research opportunities in a stimulating scientific training environment and enable trainees to launch successful independent careers in biomedical research.

项目总结/摘要 自成立以来，杰克逊实验室（JAX）一直是哺乳动物遗传学研究和教育的领导者。 成立于1929年。JAX开创了遗传学方法的发展， 哺乳动物发育问题和人类疾病的遗传基础。Jax也有一个长 以及培养博士后和最近的博士前学者的杰出记录，以提高生产力 系统遗传学、基因组学和计算生物学的研究人员。为了支持JAX的dual 发现和教育的使命，我们不断努力提供尖端的，独特的，高度相关的 为所有JAX学员提供培训机会，使其为成功的科学事业做好准备。 NIA T32资助的衰老和痴呆症精确遗传学培训计划（PGAD）将 提供高质量的研究生和博士后培训，为学员的职业生涯做好准备， 大学、研究机构和生物医学行业的调查人员。它将汇集16个高度 在位于缅因州巴尔港的JAX哺乳动物遗传学校区， JAX基因组医学校园法明顿，CT谁提供了一个独特的跨学科，综合和 全面的训练环境。老龄化和与年龄有关的疾病的研究重点包括 哺乳动物遗传学、血液学、血管生物学、免疫学、肾脏学、神经学、行为学、微生物组， 系统遗传学和生物信息学。 我们寻求为博士后研究员提供两个名额，并请求为两名博士前学生提供支持。 JAX参与协作博士学位。与塔夫茨大学医学院的培训计划， 缅因州和康涅狄格大学已经发展到临界质量。具体标准用于承认两者 博士前和博士后学员进入该计划。必修和选修课程已经制定，以丰富 培训经验。学员将测试关于衰老和疾病的遗传基础的假设， 并将使用尖端的计算和小鼠遗传学来模拟新的诊断和治疗方式 在JAX中唯一可用的资源。学员将有机会获得重点和个性化的职业生涯 发展机会，如教学和赠款写作经验，并将纳入研讨会， 研讨会和研究兴趣小组。他们将撰写外部资金申请， 科学会议，并在同行评审的期刊上发表。对受训人员的评估将是严格的， 支持增长。因此，该计划将在一个刺激的科学领域提供特殊的研究机会。 培训环境，使学员能够在生物医学研究中成功地开展独立的职业生涯。

项目成果

Improving mouse models for the study of Alzheimer's disease.

改进用于研究阿尔茨海默病的小鼠模型。

• DOI: 10.1016/bs.ctdb.2021.12.005
• 发表时间: 2022
• 期刊: Current topics in developmental biology
• 作者: Reagan,AlainaM;Onos,KristenD;Heuer,SarahE;Sasner,Michael;Howell,GarethR
• 通讯作者: Howell,GarethR

Genetic context controls early microglia-synaptic interactions in mouse models of Alzheimer's disease.

遗传背景控制阿尔茨海默病小鼠模型中的早期小胶质细胞-突触相互作用。

• DOI: 10.1101/2023.04.28.538728
• 发表时间: 2023
• 期刊: bioRxiv : the preprint server for biology
• 作者: Heuer,SarahE;Keezer,KellyJ;Hewes,AmandaA;Onos,KristenD;Graham,KourtneyC;Howell,GarethR;Bloss,ErikB
• 通讯作者: Bloss,ErikB