HIV & Aging SWG

项目摘要/摘要(艾滋病毒与老龄化科学工作组) 迈阿密-CFAR艾滋病毒和老龄科学工作组(HA-SWG)的长期目标是促进 通过多学科合作，在艾滋病毒和老龄化方面的创新和新兴研究领域。因为它的 医管局工作小组于2019年2月成立，现正积极参与研究解决 这些挑战对南佛罗里达州及其他地区感染艾滋病毒的老龄人口产生了重大影响。我们的 研究包括评估艾滋病毒相关的合并症和免疫功能障碍及其对脆弱和 认知能力下降。多种发病率研究的总主题有助于扩大 我们的特种部队。在本应用程序中，我们展示了一个经过重大修改的SWG，该SWG是在重点开发的 通过设立工作组，开展以知识为基础的活动。这些小组将研究具体的研究 利用创新方法的地区。免疫系统在衰老中的代谢调节的话题正在进行中- 研究HIV感染如何与年龄相关的免疫细胞代谢重编程及其相互作用 对较早发病的免疫功能障碍和合并症的影响需要进一步研究。我们的 目前了解老年艾滋病毒携带者(PWH)身体和认知能力脆弱的方法有 翻译关联性。房委会工作小组会进一步扩大这方面的研究范围，包括调查 肠-脑轴和肝-脑轴在神经炎症、神经认知加速过程中的作用 老年PWH的衰退和认知脆弱。在这里，我们提出了HA-SWG的两个具体目标。第一，大力发展 并促进免疫学领域的创新跨学科和协作翻译研究， 代谢调节、神经炎症、虚弱和心血管/肝脏共病。第二，我们将发展 迈阿密大学(UM)科学界内的教育和指导活动，同时加强 目标1中规定的研究目标。通过实现这些目标，HA-SWG努力为 在密歇根大学进行跨学科研究，克服虚弱、认知衰退和共病的临床挑战。 这些努力还将支持研究代谢调节机制的基础科学研究。 艾滋病毒和老龄化中的免疫力。HA-SWG还致力于创建资源丰富的基础设施，以支持 与艾滋病毒和老龄化相关的跨学科建议，支持早期调查人员和新手 艾滋病毒研究领域。为了实现我们的目标，HA-SWG具有独特的定位，可以利用临床和基础 迈阿密-CFAR可用的研究资源和专业知识，以及密歇根大学通过 麦克奈特脑研究所，神经认知科学和衰老中心，脑健康综合中心， 临床和翻译科学研究所、糖尿病研究所、希夫肝病中心和 西尔维斯特综合癌症中心。

Project Summary/Abstract (HIV and Aging Scientific Working Group) The long-term objectives of the Miami-CFAR HIV and Aging Scientific Working Group (HA-SWG) are to promote innovative and emerging areas of research in HIV and aging through multidisciplinary collaborations. Since its inception in February 2019, the HA-SWG is actively involved in research on mechanisms that address the specific challenges that significantly impact our HIV-infected aging population in South Florida and beyond. Our studies include evaluation of HIV-related comorbidities and immune dysfunction and their influence on frailty and cognitive decline. The overall theme of multi-morbidity research serves to broaden the potential and scope of our SWG. In this application, we are presenting a significantly modified SWG that was developed with a focus on knowledge-based activities through the creation of working groups. These groups will study specific research areas utilizing innovative approaches. The topic of metabolic regulation of the immune system in aging is under- investigated and how HIV infection interacts with age-related metabolic reprogramming of immune cells and its implications on the earlier onset of immune dysfunction and comorbidities demands further investigation. Our current approach to understand the physical and cognitive frailty in aging persons living with HIV (PWH) has translational relevance. The HA-SWG will further expand the scope of research in this area by investigating the role of the gut-brain axis and liver-brain axis in the processes of neuroinflammation, accelerated neurocognitive decline and cognitive frailty in aging PWH. Here we propose two specific aims of the HA-SWG. First, to develop and promote innovative cross-disciplinary and collaborative translational research in the areas of immunology, metabolic regulation, neuroinflammation, frailty and cardiovascular/liver co-morbidities. Second, we will develop educational and mentoring activities within the University of Miami (UM) scientific community while enhancing the research goals specified in Aim 1. By achieving these aims, the HA-SWG endeavors to create a platform for interdisciplinary research at UM by bridging the clinical challenges of frailty, cognitive decline and comorbidities. These efforts will also support basic science research studying the mechanisms underlying metabolic regulation of immunity in HIV and Aging. The HA-SWG is also committed to create a resource-rich infrastructure to support cross-disciplinary proposals related to HIV and aging, support Early Stage Investigators and researchers new to the field of HIV research. To achieve our goals, the HA-SWG is uniquely positioned to leverage clinical and basic research resources and expertise available to the Miami-CFAR and infrastructure available at UM through the McKnight Brain Institute, Center on Neurocognitive Science and Aging, Comprehensive Center on Brain Health, Clinical and Translational Science Institute, Diabetes Research Institute, Schiff Center for Liver Diseases and Sylvester Comprehensive Cancer Center.