HIV & Aging SWG

艾滋病病毒

• 批准号: 10621279
• 负责人: SURESH PALLIKKUTH
• 金额: $ 8.28万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-11-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621279
• 关键词: Acceleration; Acquired Immunodeficiency Syndrome; Address; Administrative Supplement; Advisory Committees; Affect; Age; Age Years; Aging; Area; Award; Basic Science; Brain; COVID-19; COVID-19 pandemic; Cardiovascular Diseases; Cardiovascular system; Cells; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinics and Hospitals; Cognitive; Cognitive aging; Collaborations; Communities; Comprehensive Cancer Center; Data; Diabetes Mellitus; Education; Evaluation; Florida; Focus Groups; General Population; Goals; HIV; HIV Infections; HIV/AIDS; Health; Health Sciences; Immune; Immune System Diseases; Immune system; Immunity; Immunologics; Immunologist; Immunology; Impaired cognition; Individual; Infrastructure; Institution; Interdisciplinary Study; Investigation; Joints; Knowledge; Lead; Life; Life Expectancy; Liver; Liver diseases; Malignant Neoplasms; Mentors; Metabolic; Microbiology; Monitor; Neurocognition; Neurocognitive; Neurocognitive Deficit; Neurologic; Neurologist; Personal Satisfaction; Persons; Population; Positioning Attribute; Process; Public Health; Publishing; Regulation; Reporting; Research; Research Institute; Research Personnel; Research Priority; Resources; Role; Science; Specific qualifier value; Strategic Planning; Talents; Translational Research; United States National Institutes of Health; Universities; Woman; age related; aging population; antiretroviral therapy; brain health; community engagement; comorbidity; early onset; frailty; gut-brain axis; immunoregulation; innovation; interest; knowledge base; medical schools; meetings; multiple chronic conditions; neuroinflammation; programs; research study; response; symposium; virtual; working group

Project Summary/Abstract (HIV and Aging Scientific Working Group) The long-term objectives of the Miami-CFAR HIV and Aging Scientific Working Group (HA-SWG) are to promote innovative and emerging areas of research in HIV and aging through multidisciplinary collaborations. Since its inception in February 2019, the HA-SWG is actively involved in research on mechanisms that address the specific challenges that significantly impact our HIV-infected aging population in South Florida and beyond. Our studies include evaluation of HIV-related comorbidities and immune dysfunction and their influence on frailty and cognitive decline. The overall theme of multi-morbidity research serves to broaden the potential and scope of our SWG. In this application, we are presenting a significantly modified SWG that was developed with a focus on knowledge-based activities through the creation of working groups. These groups will study specific research areas utilizing innovative approaches. The topic of metabolic regulation of the immune system in aging is under- investigated and how HIV infection interacts with age-related metabolic reprogramming of immune cells and its implications on the earlier onset of immune dysfunction and comorbidities demands further investigation. Our current approach to understand the physical and cognitive frailty in aging persons living with HIV (PWH) has translational relevance. The HA-SWG will further expand the scope of research in this area by investigating the role of the gut-brain axis and liver-brain axis in the processes of neuroinflammation, accelerated neurocognitive decline and cognitive frailty in aging PWH. Here we propose two specific aims of the HA-SWG. First, to develop and promote innovative cross-disciplinary and collaborative translational research in the areas of immunology, metabolic regulation, neuroinflammation, frailty and cardiovascular/liver co-morbidities. Second, we will develop educational and mentoring activities within the University of Miami (UM) scientific community while enhancing the research goals specified in Aim 1. By achieving these aims, the HA-SWG endeavors to create a platform for interdisciplinary research at UM by bridging the clinical challenges of frailty, cognitive decline and comorbidities. These efforts will also support basic science research studying the mechanisms underlying metabolic regulation of immunity in HIV and Aging. The HA-SWG is also committed to create a resource-rich infrastructure to support cross-disciplinary proposals related to HIV and aging, support Early Stage Investigators and researchers new to the field of HIV research. To achieve our goals, the HA-SWG is uniquely positioned to leverage clinical and basic research resources and expertise available to the Miami-CFAR and infrastructure available at UM through the McKnight Brain Institute, Center on Neurocognitive Science and Aging, Comprehensive Center on Brain Health, Clinical and Translational Science Institute, Diabetes Research Institute, Schiff Center for Liver Diseases and Sylvester Comprehensive Cancer Center.

项目摘要/摘要（艾滋病毒和老龄化科学工作组） 迈阿密-CFAR艾滋病毒和老龄化科学工作组（HA-SWG）的长期目标是促进 通过多学科合作，研究艾滋病毒和老龄化的创新和新兴领域。以来 HA-SWG于2019年2月成立，积极参与解决问题的机制研究 这些挑战对南佛罗里达及其他地区的艾滋病毒感染老年人口产生了重大影响。我们 研究包括评估HIV相关的合并症和免疫功能障碍及其对虚弱的影响， 认知能力下降多重发病率研究的总体主题有助于扩大 我们的SWG在这个应用程序中，我们提出了一个显着修改的SWG，是开发的重点， 通过设立工作组，开展以知识为基础的活动。这些小组将研究具体的研究 利用创新方法的领域。衰老过程中免疫系统的代谢调节的主题是在- 以及HIV感染如何与年龄相关的免疫细胞代谢重编程相互作用， 对免疫功能障碍和合并症的早期发病的影响需要进一步研究。我们 目前了解艾滋病毒感染者（PWH）身体和认知能力脆弱的方法 翻译相关性HA-SWG将通过调查 肠-脑轴和肝-脑轴在神经炎症过程中的作用，加速神经认知 衰老PWH中的衰退和认知脆弱。在这里，我们提出了HA-SWG的两个具体目标。第一，发展 促进免疫学领域的创新性跨学科和协作性转化研究， 代谢调节、神经炎症、虚弱和心血管/肝脏合并症。第二，我们将发展 迈阿密大学（UM）科学界的教育和指导活动，同时提高 目标1中规定的研究目标。通过实现这些目标，HA-SWG努力为以下方面创建一个平台： 通过弥合虚弱，认知能力下降和合并症的临床挑战，在UM进行跨学科研究。 这些努力还将支持基础科学研究，研究代谢调节的潜在机制 免疫力在艾滋病和衰老中的作用HA-SWG还致力于创建资源丰富的基础设施，以支持 与艾滋病毒和老龄化有关的跨学科建议，支持早期研究人员和新的研究人员， 艾滋病研究领域。为了实现我们的目标，HA-SWG具有独特的定位，可以利用临床和基础 研究资源和专业知识提供给迈阿密CFAR和基础设施提供在UM通过 麦克奈特脑研究所，神经认知科学和老龄化中心，脑健康综合中心， 临床和转化科学研究所，糖尿病研究所，希夫肝病中心和 西尔维斯特综合癌症中心。