The Role of Ceramides in the Intestinal Stem Cell
神经酰胺在肠干细胞中的作用
基本信息
- 批准号:10623315
- 负责人:
- 金额:$ 51.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-23 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AblationAdenocarcinomaAmino AcidsAnabolismArchitectureAutomobile DrivingCRISPR interferenceCRISPR-mediated transcriptional activationCancerousCarbohydratesCell SurvivalCellsCellular Metabolic ProcessCeramidesChronicCuesDataDetergentsDietDietary FatsDrosophila genusDyslipidemiasEnzymesEpitheliumFABP1 geneFatty Acid-Binding Protein 1Fatty AcidsGastrointestinal NeoplasmsGastrointestinal tract structureGenesGeneticGenetic TranscriptionGlucoseGrowthHigh Fat DietHumanHyperplasiaIndividualInflammationIntestinesKnockout MiceLesionLinkLipidsMacronutrients NutritionMalignant NeoplasmsMalignant neoplasm of gastrointestinal tractMediatingMetabolicMetabolismMidgutMusNatural regenerationNutrientNutritionalObesityOrganoidsPPAR alphaPalmitatesPalmitoyl Coenzyme APermeabilityPhysical condensationPlayProliferatingRiskRoleScienceSerineSignal TransductionSphingolipidsStructureTestingTissuesTransgenic MiceTumor BurdenTumorigenicityWorkbasecancer therapycell behaviorconditional knockoutcrypt celldeprivationdetection of nutrientdietaryepithelium regenerationfatty acid oxidationflygastrointestinalglucose metabolismgut healthimprovedintestinal epitheliumintestinal villilipid metabolismmouse modelnovelnovel therapeutic interventionobesogenicoxidationpharmacologicprogramsprotein metabolismresponsescaffoldserine palmitoyltransferasestem cell proliferationstem cellsstemnesstissue regenerationtumortumorigenesisuptake
项目摘要
SUMMARY
Exposing cells to excessive amounts of lipid and other nutrients promotes the accumulation of sphingolipids such
as ceramides, which alter tissue metabolism to help cells adapt to the abundance of excessive, detergent-like
fatty acids (Chaurasia et al., Science, 2019). Studies described herein reveal that ceramides play particularly
prominent roles in the gastrointestinal tract, where they increase fatty acid uptake into intestinal stem cells to
promote regeneration of the intestinal epithelium. Using organoid, fly, and mouse models, we will dissect the
mechanisms linking these sphingolipids to the control of intestinal stem cell metabolism, proliferation, and
differentiation. Moreover, we will explore the contribution of sphingolipids as signals of lipid excess that drive
gastrointestinal tumorigenesis and invasiveness. Findings obtained from these studies could uncover new
nutrient-sensing machinery that modulates intestinal stem cell proliferation and leads to new pharmacological
approaches for manipulating sphingolipids to improve gut health.
总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Bruce Alexander Edgar其他文献
Bruce Alexander Edgar的其他文献
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{{ truncateString('Bruce Alexander Edgar', 18)}}的其他基金
Sex steroid signaling and adaptive growth of the intestine
性类固醇信号传导和肠道的适应性生长
- 批准号:
10579238 - 财政年份:2021
- 资助金额:
$ 51.21万 - 项目类别:
Sex steroid signaling and adaptive growth of the intestine
性类固醇信号传导和肠道的适应性生长
- 批准号:
10378067 - 财政年份:2021
- 资助金额:
$ 51.21万 - 项目类别:
The Role of Ceramides in the Intestinal Stem Cell
神经酰胺在肠干细胞中的作用
- 批准号:
10380338 - 财政年份:2021
- 资助金额:
$ 51.21万 - 项目类别:
Sex steroid signaling and adaptive growth of the intestine
性类固醇信号传导和肠道的适应性生长
- 批准号:
10211623 - 财政年份:2021
- 资助金额:
$ 51.21万 - 项目类别:
Growth regulatory targets of the Tuberous Sclerosis Complex
结节性硬化症复合体的生长调节目标
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7131928 - 财政年份:2006
- 资助金额:
$ 51.21万 - 项目类别:
Growth regulatory targets of the Tuberous Sclerosis Complex
结节性硬化症复合体的生长调节目标
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7433900 - 财政年份:2006
- 资助金额:
$ 51.21万 - 项目类别:
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