Cell Cycle and Development

描述（由申请人提供）：本次Keystone研讨会的目标是将研究正常发育过程中细胞周期控制机制的科学家聚集在一起，使用不同的模型系统。 虽然许多定期会议都集中在发展或细胞周期控制，很少有专门解决这两个传统上独立的领域的接口。 然而，最近的研究在不同的模式生物，包括小鼠，果蝇，C。线虫和拟南芥的研究已经开始揭示许多令人兴奋的见解，即细胞周期控制机制是如何由发育程序控制的。 由于细胞周期控制和发育调控系统都是高度保守的，因此连接这两个生物过程的机制和策略也被认为是进化保守的。 因此，研究非常不同的生物的科学家可以相互学习。 本次研讨会将解决以下问题：哪些组件的细胞周期控制装置在胚胎发生和器官发生过程中进行调节？ 细胞周期调控基因如何整合不同的发育线索？ 什么机制协调细胞生长与细胞周期进程？ 虽然目的是关注正常发育而不是疾病，但理解正常增殖控制对于充分理解癌症中发生的失控增殖或伤口愈合和再生所需的增殖再活化的基础至关重要。 这一跨系统、以专题为重点的会议在促进系统间新方法的转让、突出不同模式的适当使用以及确定一般范例和无知领域方面应具有宝贵价值。 为期四天的八场会议将包括各种特邀演讲者和从提交的摘要中选出的演讲者的演讲。 下午则用于海报展示和非正式互动。 因为这种类型的大型会议之前没有举行过，我们认为这次研讨会将是一个独特的培训和网络场所的主要研究人员以及博士后和研究生参与细胞周期控制的研究在发展过程中。

DESCRIPTION (provided by applicant): The goal of this Keystone Symposium is to bring together scientists studying the mechanisms of cell cycle control during normal development, using diverse model systems. Although many regular meetings are focused on either development or cell cycle control, exceedingly few have specifically addressed the interface of these two traditionally separate fields. Nevertheless, recent research in divergent model organisms including mice, Drosphila, C. elegans, and Arabidopsis, has begun to reveal many exciting insights into how the cell cycle control machinery is governed by developmental programs. Since both cell cycle control and developmental regulatory systems are highly conserved, the mechanisms and strategies connecting these two biological processes are also expected to be evolutionary conserved. Hence scientists working on very different organisms can learn tremendously from one another. This Symposium will address the following questions: Which components of the cell cycle control apparatus are regulated during embryogenesis and organogenesis? How are diverse developmental cues integrated by cell cycle regulatory genes? What mechanisms coordinate cell growth with cell cycle progression? Although the intent is to focus on normal development rather than disease, an understanding of normal proliferative control will be essential to fully understand the basis of the deregulated proliferation that occurs in cancer, or the proliferative re-activation required for wound healing and regeneration. This cross-system, topic-focused meeting should be invaluable in promoting the transfer of new methodologies between systems, highlighting the appropriate uses of the different models, and defining general paradigms and areas of ignorance. Eight sessions running over four days will consist of talks from a diverse array of invited speakers and speakers selected from submitted abstracts. Afternoons are reserved for poster presentations and informal interactions. Because a large meeting of this type has not been held before, we think this Symposium will be a unique training and networking venue for principal Investigators as well as postdoctorals and graduate students involved in studies of cell cycle control during development.