MARC at University of California, Davis

加州大学戴维斯分校 MARC

• 批准号: 10625326
• 负责人: ALDRIN V. GOMES
• 金额: $ 50.11万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625326
• 关键词: Bachelor' s Degree; Biomedical Research; CCL7 gene; California; Communication; Communities; Data Analyses; Development; Discipline; Doctor of Philosophy; Ethics; Experimental Designs; Goals; Learning; Measurable; Mentors; Mentorship; Mission; Oral; Process; Research; Research Design; STEM field; Science; Self Efficacy; Social support; Source; Students; Time; Training Programs; Underrepresented Populations; Universities; Writing; career; collaborative environment; experience; faculty research; graduate school; graduate student; outreach; programs; recruit; skills; social; student participation; student retention; symposium

Abstract The mission of the UC Davis MARC program is to increase the diversity of students who complete their baccalaureate degree, and subsequently pursue a PhD or MD/PhD in a biomedical research-focused STEM field. To achieve this, we have developed an academic and research-focused training program for students in underrepresented groups in biomedical sciences. To fulfill this mission, we propose to recruit 10 students, annually, to participate in a two to three year MARC training program, which will include at least two summers of full-time research and two academic years of part-time research. Our MARC program will promote student retention and academic excellence through activities that facilitate social and academic integration and scientific identity formation within a supportive peer group environment. It will engage students in research as well as in discussions of biomedical research topics, integrity in research, and experimental design. It will also provide them with experience in scientific presentations both oral and written, experience in proposal writing, guidance in the graduate school application process, and career information. To achieve these goals, our MARC program will have four main components: advising, research experience, professional development, and community activities that enhance science identity formation and provide important sources of social support. This program has the following measurable objectives. MARC students will: (1) learn the importance of conducting biomedical research responsibly, ethically, and with integrity; (2) increase their scientific research expertise with respect to understanding scientific reasoning, rigorous experimental design, data analysis, and interpretation; (3) develop skills to communicate scientific research to a variety of audiences, including those at national conferences; (4) develop a science identity, science community values, self-efficacy, and sense of belonging; (5) develop a network of supportive mentors who are at a variety of career stages, including faculty research mentors and graduate students; (6) engage in outreach and/or mentorship activities; (7) be extensively prepared to create competitive graduate school applications; (8) maintain/enhance their commitment to careers in biomedical research; (9) graduate at a rate of 90% with a GPA that is competitive for entrance into a PhD program; and (10) enter PhD or MD/PhD programs in biomedical related disciplines within 3 years of graduation at a rate of at least 60%.

摘要 加州大学戴维斯分校MARC计划的使命是增加学生的多样性， 学士学位，随后在以生物医学研究为重点的STEM中攻读博士或MD/PhD 领域为了实现这一目标，我们为学生制定了一个以学术和研究为重点的培训计划 在生物医学科学中代表性不足的群体中。为了完成这一使命，我们建议招收10名学生， 每年，参加一个为期两到三年的MARC培训计划，其中至少包括两个夏天 全职研究和两年的兼职研究。我们的MARC计划将促进学生 通过促进社会和学术融合以及科学研究的活动， 在一个支持性的同龄人群体环境中形成身份。它将让学生参与研究以及 讨论生物医学研究主题，研究的完整性和实验设计。它还将提供 他们有口头和书面科学报告的经验，有提案写作的经验， 在研究生院申请过程中，以及职业信息。为了实现这些目标，我们的MARC计划 将有四个主要组成部分：咨询，研究经验，专业发展，和社区 加强科学身份形成并提供重要社会支持来源的活动。这个程序 有以下可衡量的目标。MARC学生将：（1）学习进行的重要性 生物医学研究负责任，道德和诚信;（2）增加他们的科学研究专业知识， 尊重理解科学推理，严格的实验设计，数据分析和解释; (3)培养向各种受众传播科学研究的技能，包括国家级受众。 （4）培养科学身份、科学共同体价值观、自我效能感和归属感; (5)发展一个支持导师的网络，他们处于各种职业阶段，包括教师研究 导师和研究生;（6）参与外展和/或导师活动;（7）做好充分准备 创造有竞争力的研究生院申请;（8）保持/加强他们对职业的承诺， 生物医学研究;（9）以90%的速度毕业，GPA具有进入博士学位的竞争力 计划;以及（10）在毕业后3年内进入生物医学相关学科的博士或MD/PhD课程 至少有60%。

项目成果

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer.

BRCA2 缺陷型胰腺癌中自噬增强导致 BET 抑制的新脆弱性。

• DOI: 10.1038/s41419-023-06145-9
• 发表时间: 2023-09-21
• 期刊: CELL DEATH & DISEASE
• 影响因子: 9
• 作者: Lee, Eunjung;Archasappawat, Suyakarn;Ji, Keely;Pena, Jocelyn;Fernandez-Vega, Virneliz;Gangaraju, Ritika;Beesabathuni, Nitin Sai;Kim, Martin Jean;Tian, Qi;Shah, Priya S.;Scampavia, Louis;Spicer, Timothy P.;Hwang, Chang-Il
• 通讯作者: Hwang, Chang-Il