Regulation of Ferroptosis by the p53/CDK/Rb Axis.

p53/CDK/Rb 轴对铁死亡的调节。

• 批准号: 10632830
• 负责人: William R. Taylor
• 金额: $ 1.29万
• 依托单位: UNIVERSITY OF TOLEDO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10632830
• 关键词: Administrative Supplement; Cell Death; Cell Death Process; Cells; Floods; Freezing; Funding; Location; Malignant Neoplasms; Parents; Pathway interactions; Proteins; Reagent; Regulation; Research; Sampling; System; Systemic Therapy; TP53 gene; Work; cancer cell; cancer therapy; cancer type

Project Summary/Abstract: Many types of cancer are still detected to late to be effectively treated. Therefore, new systemic therapies for cancer are required. In our parent application we proposed to investigate the cell death mechanism called ferroptosis as a potential means to kill cancer cells. Our studies were focused on understanding important cellular pathways that modulate ferroptosis to uncover better mechansism to specifically target cancer cells. While our work was underway, damage to the HVAC system in our building resulted in flooding of a neighboring labortory. As a result, that lab will relocate to another location in the building and will remove an ultralow (-80°C) freezer that my lab was using to store samples. This freezer is essential to store bacterial stocks, cell lysates, protein samples among other important reagents. The purpose of this administrative supplement is to seeks funds to purchase an ultralow -80°C freezer so that our research may continue without major disruption.

项目总结/文摘:

项目成果

Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis.

• DOI: 10.1021/acs.jmedchem.2c00909
• 发表时间: 2022-09-08
• 期刊: Journal of medicinal chemistry
• 影响因子: 7.3
• 作者: Karaj E;Sindi SH;Kuganesan N;Perera L;Taylor W;Tillekeratne LMV
• 通讯作者: Tillekeratne LMV

C9ORF78 partially localizes to centromeres and plays a role in chromosome segregation.

• DOI: 10.1016/j.yexcr.2022.113063
• 发表时间: 2022-02
• 期刊: Experimental cell research
• 影响因子: 3.7
• 作者: Radhika Koranne;Kayla M. Brown;Hannah Vandenbroek;W. Taylor