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Functional and Neurochemical Substrates of Amygdala-Frontal Circuitry across Development and Anxiety (COVID-19 Supplement)

杏仁核-额叶回路跨越发育和焦虑的功能和神经化学底物（COVID-19 补充材料）

基本信息

批准号：
10631017
负责人：
Shaolin Yang
金额：
$ 6.08万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-12 至 2023-08-11
项目状态：
已结题

项目摘要

ABSTRACT R21 MH116475 entitled “Functional and Neurochemical Substrates of Amygdala-Frontal Circuitry across Development and Anxiety” (FANSDA) is to examine the developmental trajectories of amygdala-frontal (particularly the anterior cingulate cortex [ACC]) circuitry in healthy (N = 40) and anxious (with generalized anxiety disorder [GAD], N = 40) participants between 16 to 26 years old. The overarching objective of this study is to uncover an integrated functional-neurochemical biomarker for healthy versus anxious development. The award was originally received by the PI at the University of Illinois at Chicago (UIC) on August 12, 2020. As the PI moved from UIC to University of Pittsburgh (Pitt), the award was transferred from UIC to Pitt on April 8, 2021. After the project was set up at Pitt, following the university and department guidelines for COVID, we had to halt recruitment from time to time as the scanner site had to be shut down because of the infection of the staff. As of April 2022, we have recruited 18 participants, 17 participants have been interviewed for behavioral and neuropsychological measures and 8 participants have completed the final MRI scans. We are confident that we will eventually recruit 80 subjects (40 subjects in each group). We request the fund that is specifically aimed to recover salaries paid due to the COVID pandemic shutdown. This proposal is responsive to NOT-MH-21-120 as 1) it is within the scope of the funded research; 2) FANSDA is in the last year of the award; 3) completion of enrollment is critical for the success of the current project.

摘要 R21 MH 116475，标题为“杏仁核-额叶回路的功能和神经化学底物，发展与焦虑”（FANSDA）是研究杏仁核-额叶皮层的发展轨迹，（特别是前扣带皮层[ACC]）电路在健康（N = 40）和焦虑（广义焦虑障碍[GAD]，N = 40）16 - 26岁的参与者。本报告的总体目标这项研究旨在揭示健康与焦虑发展的综合功能神经化学生物标志物。该奖项最初由PI于2020年8月12日在伊利诺伊大学芝加哥分校（UIC）获得。由于PI从UIC转移到匹兹堡大学（皮特），该奖项于4月12日从UIC转移到皮特大学。 2021年8月8日该项目在皮特成立后，遵循大学和部门对COVID的指导方针，我们不得不不时停止招聘，因为扫描网站不得不关闭，因为感染了工作人员。截至2022年4月，我们已招募18名参与者，17名参与者已接受面试，行为和神经心理学测量，8名参与者完成了最终的MRI扫描。我们我们有信心最终招募80名受试者（每组40名受试者）。我们要求基金，特别旨在收回因新型冠状病毒疫情停工而支付的工资。这项建议是响应NOT-MH-21-120，因为1）它在资助研究的范围内; 2）FANSDA在最后一年的奖励; 3）完成招生是本项目成功的关键。