Functional and Neurochemical Substrates of Amygdala-Frontal Circuitry across Development and Anxiety
杏仁核-额叶回路跨越发育和焦虑的功能和神经化学底物
基本信息
- 批准号:10058131
- 负责人:
- 金额:$ 1.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-12 至 2020-11-17
- 项目状态:已结题
- 来源:
- 关键词:AdolescenceAdolescentAdultAffectAge-YearsAmericanAmygdaloid structureAnimal ExperimentationAnimalsAnteriorAnxietyAnxiety DisordersBiological MarkersBrainBrain StemChildChildhoodCognitiveDevelopmentEarly InterventionEmotionsEquilibriumExhibitsFaceFailureFrightFunctional Magnetic Resonance ImagingFunctional disorderGeneralized Anxiety DisorderGlutamatesHealthHumanImpairmentIndividualInterneuronsInvasive LesionLearningMagnetic Resonance SpectroscopyMeasuresMedialNeurosciences ResearchNeurotransmittersOutcomeParticipantPathological anxietyPathway interactionsPhasePlayPrefrontal CortexPrevalencePreventionProcessRegulationReportingResearchResponse to stimulus physiologyRiskRoleSeveritiesShapesSignal TransductionSourceStimulusSystemTimeUnited StatesWorkadaptive learninganxiety symptomsanxiouscingulate cortexdesignemerging adultemotion regulationflexibilitygamma-Aminobutyric Acidhigh riskhippocampal pyramidal neuronmultimodalityneurochemistryneuroimagingneurotransmissionnovelpre-clinicalpsychologicresponsesocialtraittreatment strategyyoung adult
项目摘要
Generalized anxiety disorder (GAD) is a debilitating illness characterized by persistent and exaggerated
worrying. It can disruptively interfere with everyday functioning, and is associated with poor health, and
negative financial and social outcomes. As one of the most common anxiety disorders, GAD affects millions of
Americans each year with a 12-month prevalence of 3.1%. Compared to the stable rates in children and
younger adolescents, new onset of GAD increases substantially from 16 to 26 years of age, suggesting the
transition from late adolescence to early adulthood as a key high-risk stage for GAD. Amygdala-frontal
circuitry, particularly functional interactions between the amygdala and anterior cingulate cortex (ACC), plays a
critical role in threat processing and emotional regulation, and has been centrally implicated in anxiety
disorders. Specifically, adult-like connectivity/activity in the ACC appears to emerge in late adolescence, and
gradually develops into adulthood as an effective top-down inhibitory regulation. It is possible that
developmental deviations of the amygdala-ACC interaction may trigger the development of GAD during the
transition from late adolescence to early adulthood. Therefore, a cross-sectional multimodal study (fMRI+MRS
[functional MRI + magnetic resonance spectroscopy]) is designed to examine the developmental trajectories of
amygdala-ACC circuitry in healthy (N = 40) and anxious (N = 40) participants between 16 to 26 years old. The
overarching objective of this study is to uncover an integrated functional-neurochemical biomarker for healthy
versus anxious development. Specifically, fMRI will be used to measure the functional connectivity between
the amygdala and the ACC in response to social threats; 1H-MRS will be used to measure the concentrations
of the primary excitatory neurotransmitter glutamate and the primary inhibitory neurotransmitter GABA (γ-
aminobutyric acid) in the ACC. Disrupted functional connectivity and imbalanced neurochemistry as identified
in this study can serve as objective and developmentally sensitive markers for identifying at-risk individuals for
early intervention and prevention of GAD. The integrated functional-neurochemical biomarker of healthy and
anxious development can also guide the development of novel treatments targeting at the glutamatergic and
GABAergic systems from a neurodevelopmental perspective.
广泛性焦虑障碍(GAD)是一种以持续性和扩张性为特征的衰弱性疾病
项目成果
期刊论文数量(0)
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Shaolin Yang其他文献
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{{ truncateString('Shaolin Yang', 18)}}的其他基金
Functional and Neurochemical Substrates of Amygdala-Frontal Circuitry across Development and Anxiety (COVID-19 Supplement)
杏仁核-额叶回路跨越发育和焦虑的功能和神经化学底物(COVID-19 补充材料)
- 批准号:
10631017 - 财政年份:2020
- 资助金额:
$ 1.37万 - 项目类别:
Functional and Neurochemical Substrates of Amygdala-Frontal Circuitry across Development and Anxiety
杏仁核-额叶回路跨越发育和焦虑的功能和神经化学底物
- 批准号:
10333667 - 财政年份:2020
- 资助金额:
$ 1.37万 - 项目类别:
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