Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
基本信息
- 批准号:10631776
- 负责人:
- 金额:$ 11.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-06-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:16S ribosomal RNA sequencingAddressAdoptedAnimalsBiologicalBody Weight decreasedCardiometabolic DiseaseCardiovascular DiseasesCollectionCommunitiesComplexConsensusCountryDNADataDietDietary ComponentDietary InterventionDietary PracticesEatingFecesFundingFutureGoalsGrantHealthHeartHomeInterventionIntervention TrialKnowledgeLifeLinear RegressionsLiteratureLow incomeMeasuresMediatingMediator of activation proteinMetabolismMinority GroupsNon-Insulin-Dependent Diabetes MellitusNutrientObesity EpidemicOutcomeParentsParticipantPathway interactionsPatient RecruitmentsPatientsPatternPersonal SatisfactionPlantsPrimary Health CareProductionPublic HealthRandomizedRandomized Controlled TrialsReportingResearchRibosomal RNASamplingScholarshipSecureStructureSuggestionTestingTimeVolatile Fatty AcidsWeightbasebeta diversitycardiometabolic riskcardiometabolismcardiovascular disorder riskcohortdesigndietaryethnic diversityfollow-upgood dietgut microbiotahealth equityimprovedinnovationlifestyle interventionmicrobialmicrobiotamulti-ethnicpreferenceprospectiveracial and ethnicrandomized trialresponsesocioeconomicsstool sampletherapy designtreatment armtreatment as usualweight loss intervention
项目摘要
PROJECT SUMMARY
The obesity epidemic has fueled major increases in cardiometabolic diseases. A growing body of evidence
suggests that cardiometabolic diseases are associated with an altered gut microbiota. Observational and
intervention data agree that there is suggestive evidence that a heart-healthy Mediterranean-style diet may be
associated with beneficial changes in gut microbiota. However, the literature has yet to reach consensus. More
research needs to be done on how the gut microbiota may mediate dietary effects on cardiometabolic risk
within community-based dietary interventions. It is important that scholarship take place within community-
based dietary interventions so that the dietary changes being measured are of whole diets (rather than a
specific dietary component) and thus are more sustainable by participants. To address these gaps, this grant
proposes a diversity supplement to the Randomized Explanatory Trial of a Mediterranean Dietary Pattern
Weight Loss Intervention for Primary Care Practices (R33HL142680). The overarching purpose of the parent
R33 is to test whether a weight loss intervention emphasizing a healthful eating pattern (Med-South) can yield
long-term weight loss and improved CVD risk profiles over usual care (WWTM—formerly Weight Watchers).
The study will test the impact of the Med-South intervention by assessing outcomes at 4, 12, and 24 months in
a sample of 360 patients. Fecal samples will also be collected at each timepoint. The current proposal
leverages the patients recruited in the parent R33 to investigate the impacts of the Med-South intervention on
the gut microbiota over time. To do this, we will complete 16S rRNA sequencing on stool DNA using baseline
and 4-month intervention samples. Our goals are to (1) assess cross-sectional association between
participants' baseline pre-intervention diet and microbiota composition, and (2) test the changes in the gut
microbial community composition from baseline through four months of intervention follow-up. For each study
participant, microbial measures for analysis include: (1) alpha-diversity, (2) beta-diversity, and (3) abundances
of distinct taxa (genera).
项目总结
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('THOMAS C KEYSERLING', 18)}}的其他基金
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
- 批准号:
10320207 - 财政年份:2021
- 资助金额:
$ 11.12万 - 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
- 批准号:
10249218 - 财政年份:2019
- 资助金额:
$ 11.12万 - 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
- 批准号:
10890277 - 财政年份:2019
- 资助金额:
$ 11.12万 - 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
- 批准号:
10890282 - 财政年份:2019
- 资助金额:
$ 11.12万 - 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
- 批准号:
10683441 - 财政年份:2019
- 资助金额:
$ 11.12万 - 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
- 批准号:
10026331 - 财政年份:2019
- 资助金额:
$ 11.12万 - 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
- 批准号:
10681486 - 财政年份:2019
- 资助金额:
$ 11.12万 - 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
- 批准号:
10470855 - 财政年份:2019
- 资助金额:
$ 11.12万 - 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
- 批准号:
10462032 - 财政年份:2019
- 资助金额:
$ 11.12万 - 项目类别:
A COMBINED LIFESTYLE AND MEDICATION INTERVENTION TO REDUCE CVD RISK
生活方式和药物相结合的干预措施可降低 CVD 风险
- 批准号:
8051286 - 财政年份:2010
- 资助金额:
$ 11.12万 - 项目类别:
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