Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices

地中海饮食模式减肥干预初级保健实践的随机解释性试验

基本信息

  • 批准号:
    10631776
  • 负责人:
  • 金额:
    $ 11.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-06-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY The obesity epidemic has fueled major increases in cardiometabolic diseases. A growing body of evidence suggests that cardiometabolic diseases are associated with an altered gut microbiota. Observational and intervention data agree that there is suggestive evidence that a heart-healthy Mediterranean-style diet may be associated with beneficial changes in gut microbiota. However, the literature has yet to reach consensus. More research needs to be done on how the gut microbiota may mediate dietary effects on cardiometabolic risk within community-based dietary interventions. It is important that scholarship take place within community- based dietary interventions so that the dietary changes being measured are of whole diets (rather than a specific dietary component) and thus are more sustainable by participants. To address these gaps, this grant proposes a diversity supplement to the Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices (R33HL142680). The overarching purpose of the parent R33 is to test whether a weight loss intervention emphasizing a healthful eating pattern (Med-South) can yield long-term weight loss and improved CVD risk profiles over usual care (WWTM—formerly Weight Watchers). The study will test the impact of the Med-South intervention by assessing outcomes at 4, 12, and 24 months in a sample of 360 patients. Fecal samples will also be collected at each timepoint. The current proposal leverages the patients recruited in the parent R33 to investigate the impacts of the Med-South intervention on the gut microbiota over time. To do this, we will complete 16S rRNA sequencing on stool DNA using baseline and 4-month intervention samples. Our goals are to (1) assess cross-sectional association between participants' baseline pre-intervention diet and microbiota composition, and (2) test the changes in the gut microbial community composition from baseline through four months of intervention follow-up. For each study participant, microbial measures for analysis include: (1) alpha-diversity, (2) beta-diversity, and (3) abundances of distinct taxa (genera).
项目摘要 肥胖症的流行助长了心脏代谢疾病的大幅增加。越来越多的证据 表明心脏代谢疾病与肠道菌群的改变有关。观测和 干预数据一致认为,有暗示性证据表明,有益心脏健康的地中海式饮食可能 与肠道微生物群的有益变化有关。然而,文献尚未达成共识。更 需要研究肠道微生物群如何介导饮食对心脏代谢风险的影响 在以社区为基础的饮食干预中。重要的是,奖学金发生在社区- 基于饮食干预,以便测量的饮食变化是整个饮食(而不是 具体饮食成分),因此对参与者来说更可持续。为了弥补这些差距, 建议对地中海饮食模式的随机试验进行多样性补充 初级保健实践的体重减轻干预(R33 HL 142680)。家长的首要目的 R33是为了测试强调健康饮食模式(Med-South)的减肥干预是否能产生 长期减肥和改善心血管疾病的风险概况超过常规护理(WWTM-以前的体重观察者)。 这项研究将通过评估4个月、12个月和24个月的结果来测试地中海-南部干预的影响。 360名患者的样本。还将在每个时间点采集粪便样本。现时的建议 利用在父R33招募的患者调查Med-South干预对 肠道菌群的变化为此,我们将使用基线技术完成粪便DNA的16 S rRNA测序, 和4个月干预样本。我们的目标是(1)评估 参与者的基线干预前饮食和微生物群组成,以及(2)测试肠道的变化 从基线到四个月的干预随访的微生物群落组成。对于每项研究 参与者,用于分析的微生物措施包括:(1)α多样性,(2)β多样性和(3)丰度 不同的分类群(属)。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

THOMAS C KEYSERLING其他文献

THOMAS C KEYSERLING的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('THOMAS C KEYSERLING', 18)}}的其他基金

Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
  • 批准号:
    10320207
  • 财政年份:
    2021
  • 资助金额:
    $ 11.12万
  • 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
  • 批准号:
    10249218
  • 财政年份:
    2019
  • 资助金额:
    $ 11.12万
  • 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
  • 批准号:
    10890277
  • 财政年份:
    2019
  • 资助金额:
    $ 11.12万
  • 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
  • 批准号:
    10890282
  • 财政年份:
    2019
  • 资助金额:
    $ 11.12万
  • 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
  • 批准号:
    10683441
  • 财政年份:
    2019
  • 资助金额:
    $ 11.12万
  • 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
  • 批准号:
    10026331
  • 财政年份:
    2019
  • 资助金额:
    $ 11.12万
  • 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
  • 批准号:
    10681486
  • 财政年份:
    2019
  • 资助金额:
    $ 11.12万
  • 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
  • 批准号:
    10470855
  • 财政年份:
    2019
  • 资助金额:
    $ 11.12万
  • 项目类别:
Randomized Explanatory Trial of a Mediterranean Dietary Pattern Weight Loss Intervention for Primary Care Practices
地中海饮食模式减肥干预初级保健实践的随机解释性试验
  • 批准号:
    10462032
  • 财政年份:
    2019
  • 资助金额:
    $ 11.12万
  • 项目类别:
A COMBINED LIFESTYLE AND MEDICATION INTERVENTION TO REDUCE CVD RISK
生活方式和药物相结合的干预措施可降低 CVD 风险
  • 批准号:
    8051286
  • 财政年份:
    2010
  • 资助金额:
    $ 11.12万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 11.12万
  • 项目类别:
    Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 11.12万
  • 项目类别:
    Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 11.12万
  • 项目类别:
    Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 11.12万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 11.12万
  • 项目类别:
    Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 11.12万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 11.12万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 11.12万
  • 项目类别:
    EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 11.12万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 11.12万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了