Predoctoral and Postdoctoral Training in Alzheimer's Pathophysiology

项目概要/摘要 我们建议在糖尿病的病理生理学方面建立一个高度合作的博士前和博士后培训计划。 阿尔茨海默病和其他相关的新保守主义疾病。我们的计划是致力于推进前- 和博士后研究员成为研究密集型大学和卫生部门的独立研究科学家- 相关研究实验室。我们的学员将由米切尔中心的成员指导， 德克萨斯大学医学分支-加尔维斯顿的神经退行性疾病。我们的高度合作 教师跨越多个部门，使他们能够采用一些实验方法， 与阿尔茨海默病有关的问题。我们的培训计划包括细胞动物模型， 疾病进展机制和药理学操作，免疫学方法靶向 tau蛋白和淀粉样蛋白低聚物，突触电生理学，神经变性中的DNA损伤和修复， 突触发育和退化的遗传学，认知弹性的分子机制，以及 神经变性的代谢决定因素。我们培训计划的优势在于UTMB的投资 在发展这个高度合作的团队，我们的联合出版物和资助赠款证明。 我们的四名博士前和三名博士后学员将在整个培训过程中得到密切指导。我们的博士预科 学员将被要求学习几门专门研究神经退行性疾病中细胞信号传导的新课程， 淀粉样蛋白的生物化学和生物物理学，而我们的博士后学员将参加一个 高级生物医学研究战略证书课程。所有受训人员将参加研讨会， 社区建设活动、期刊俱乐部和积极的合作研究培训。我们提出了一种 框架，这将使我们能够培训和指导前和博士后学员的方式成为 独立的科学家，以帮助解决阿尔茨海默氏症的医疗需求的国家。

Project Summary/Abstract We proposed creating a highly collaborative pre- and post-doctoral training program in the pathophysiology of Alzheimer’s disease and other related neoconservative disorders. Our program is dedicated on advancing pre- and post-doctoral fellows into independent research scientists at research intensive universities and health- related research laboratories. Our trainees will be mentored by members of the Mitchell Center for Neurodegenerative Diseases at the University of Texas Medical Branch – Galveston. Our highly collaborative faculty reach across multiple departments allowing them to employ a number of experimental approaches to the problems associated with Alzheimer's disease. Our training program incorporates cellular animal models, disease progression mechanisms and pharmacological manipulations, immunotherapeutic approaches targeting tau and amyloid oligomers, synaptic electrophysiology and, DNA damage and repair in neurodegeneration, genetics of synaptic development and degeneration, molecular mechanisms in cognitive resilience, and metabolic determinants of neurodegeneration. A strength of our training program is the investment UTMB has made in developing this highly collaborative team as demonstrated by our joint publications and funded grants. Our four pre-and three post-doctoral trainees will be closely mentored throughout their training. Our pre-doctoral trainees will be required to take several new courses devoted to the cellular signaling in neurodegeneration and the biochemistry and biophysics of amyloid proteins, while our post-doctoral trainees will participate in a certificate program in advanced biomedical research strategies. All trainees will participate in seminars, community building events, journal clubs and active collaborative research training. We have proposed a framework that will enable us to train and mentor both pre- and post-doctoral trainees on their way to becoming independent scientist to help address the Alzheimer’s medical needs of the country.