Predoctoral and Postdoctoral Training in Alzheimer's Pathophysiology

项目摘要/摘要 我们建议创建一个高度协作的博士后前和博士后培训计划，在病理生理学方面 阿尔茨海默病和其他相关的新保守主义疾病。我们的节目致力于推进预制 和博士后研究员成为研究密集型大学和卫生领域的独立研究科学家- 相关研究实验室。我们的实习生将由米切尔中心的成员指导 德克萨斯大学加尔维斯顿分校的神经退行性疾病。我们高度协作 教员跨越多个部门，允许他们采用许多实验性的方法来 与阿尔茨海默氏症相关的问题。我们的训练计划包含了细胞动物模型， 疾病进展机制和药物操作，靶向免疫治疗方法 Tau和淀粉样寡聚体，突触电生理学，神经退行性变中的DNA损伤和修复， 突触发育和退化的遗传学，认知弹性的分子机制，以及 神经退行性变的代谢决定因素。我们培训计划的一个优势是UTMB的投资 我们在发展这一高度协作的团队方面取得了进展，我们的联合出版物和资助赠款证明了这一点。 我们的四名博士后和三名博士后实习生将在整个培训过程中得到密切指导。我们的博士前 受训人员将被要求参加几门新课程，专门研究神经退行性变中的细胞信号和 淀粉样蛋白的生物化学和生物物理学，而我们的博士后实习生将参加一个 高级生物医学研究策略证书课程。所有学员都将参加研讨会， 社区建设活动、期刊俱乐部和积极的合作研究培训。我们已经提出了一个 这一框架将使我们能够培训和指导博士后和博士后实习生成为 帮助解决该国阿尔茨海默氏症医疗需求的独立科学家。

Project Summary/Abstract We proposed creating a highly collaborative pre- and post-doctoral training program in the pathophysiology of Alzheimer’s disease and other related neoconservative disorders. Our program is dedicated on advancing pre- and post-doctoral fellows into independent research scientists at research intensive universities and health- related research laboratories. Our trainees will be mentored by members of the Mitchell Center for Neurodegenerative Diseases at the University of Texas Medical Branch – Galveston. Our highly collaborative faculty reach across multiple departments allowing them to employ a number of experimental approaches to the problems associated with Alzheimer's disease. Our training program incorporates cellular animal models, disease progression mechanisms and pharmacological manipulations, immunotherapeutic approaches targeting tau and amyloid oligomers, synaptic electrophysiology and, DNA damage and repair in neurodegeneration, genetics of synaptic development and degeneration, molecular mechanisms in cognitive resilience, and metabolic determinants of neurodegeneration. A strength of our training program is the investment UTMB has made in developing this highly collaborative team as demonstrated by our joint publications and funded grants. Our four pre-and three post-doctoral trainees will be closely mentored throughout their training. Our pre-doctoral trainees will be required to take several new courses devoted to the cellular signaling in neurodegeneration and the biochemistry and biophysics of amyloid proteins, while our post-doctoral trainees will participate in a certificate program in advanced biomedical research strategies. All trainees will participate in seminars, community building events, journal clubs and active collaborative research training. We have proposed a framework that will enable us to train and mentor both pre- and post-doctoral trainees on their way to becoming independent scientist to help address the Alzheimer’s medical needs of the country.