Predoctoral and Postdoctoral Training in Alzheimer's Pathophysiology

阿尔茨海默病病理生理学博士前和博士后培训

• 批准号: 10627752
• 负责人: Rakez Kayed
• 金额: $ 34.91万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627752
• 关键词: Alzheimer' s Disease; Functional disorder; post-doctoral training; pre-doctoral

Project Summary/Abstract We proposed creating a highly collaborative pre- and post-doctoral training program in the pathophysiology of Alzheimer’s disease and other related neoconservative disorders. Our program is dedicated on advancing pre- and post-doctoral fellows into independent research scientists at research intensive universities and health- related research laboratories. Our trainees will be mentored by members of the Mitchell Center for Neurodegenerative Diseases at the University of Texas Medical Branch – Galveston. Our highly collaborative faculty reach across multiple departments allowing them to employ a number of experimental approaches to the problems associated with Alzheimer's disease. Our training program incorporates cellular animal models, disease progression mechanisms and pharmacological manipulations, immunotherapeutic approaches targeting tau and amyloid oligomers, synaptic electrophysiology and, DNA damage and repair in neurodegeneration, genetics of synaptic development and degeneration, molecular mechanisms in cognitive resilience, and metabolic determinants of neurodegeneration. A strength of our training program is the investment UTMB has made in developing this highly collaborative team as demonstrated by our joint publications and funded grants. Our four pre-and three post-doctoral trainees will be closely mentored throughout their training. Our pre-doctoral trainees will be required to take several new courses devoted to the cellular signaling in neurodegeneration and the biochemistry and biophysics of amyloid proteins, while our post-doctoral trainees will participate in a certificate program in advanced biomedical research strategies. All trainees will participate in seminars, community building events, journal clubs and active collaborative research training. We have proposed a framework that will enable us to train and mentor both pre- and post-doctoral trainees on their way to becoming independent scientist to help address the Alzheimer’s medical needs of the country.

项目总结/文摘

项目成果

Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia.

• DOI: 10.1016/j.celrep.2021.109419
• 发表时间: 2021-07-20
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Gaikwad S;Puangmalai N;Bittar A;Montalbano M;Garcia S;McAllen S;Bhatt N;Sonawane M;Sengupta U;Kayed R
• 通讯作者: Kayed R

Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies.

• DOI: 10.1007/s12035-023-03211-3
• 发表时间: 2023-05
• 期刊: MOLECULAR NEUROBIOLOGY
• 影响因子: 5.1
• 作者: Moore, Kenya;Sengupta, Urmi;Puangmalai, Nicha;Bhatt, Nemil;Kayed, Rakez
• 通讯作者: Kayed, Rakez

Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies.

• DOI: 10.1111/bpa.13112
• 发表时间: 2023-01
• 期刊: BRAIN PATHOLOGY
• 影响因子: 6.4
• 作者: Montalbano, Mauro;Majmundar, Lajja;Sengupta, Urmi;Fung, Leiana;Kayed, Rakez
• 通讯作者: Kayed, Rakez

Microbial determinants of dementia risk in subjects of Mexican descent with type 2 diabetes living in South Texas.

生活在德克萨斯州南部的墨西哥裔 2 型糖尿病患者痴呆风险的微生物决定因素。

• DOI: 10.1101/2024.03.20.24304637
• 发表时间: 2024
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Matz,LisaM;Shah,NisargS;Porterfield,Laura;Stuyck,OliviaM;Jochum,MichaelD;Kayed,Rakez;Taglialatela,Giulio;Urban,RandallJ;Buffington,ShellyA
• 通讯作者: Buffington,ShellyA