Cancer Prevention and Control Program

癌症预防和控制计划

• 批准号: 10627032
• 负责人: Darla Elizabeth Kendzor
• 金额: $ 7.83万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627032
• 关键词: Address; African American; American Indians; Area; Basic Science; Behavioral; Behavioral Sciences; Black race; Cancer Center; Cancer Center Support Grant; Cancer Control; Catchment Area; Chemopreventive Agent; Clinical Sciences; Collaborations; Community Outreach; Complex; Continuance of life; Continuity of Patient Care; Critiques; DNA Damage; Development; Disease; Disparity; Doctor of Philosophy; Economically Deprived Population; Emerging Tobacco Products; Evaluation; Faculty; Financial Hardship; Funding; Future; Genetic; Genomics; Goals; Growth; Health Services Accessibility; Health behavior; Incentives; Incidence; Inflammatory; Institution; Intervention; Intervention Trial; Laboratories; Life Style Modification; Malignant Neoplasms; Menthol; Mentors; Mentorship; Monitor; NCI-Designated Cancer Center; Not Hispanic or Latino; Oklahoma; Outcome; Pain management; Pathway interactions; Peer Review; Play; Population; Population Sciences; Positioning Attribute; Postdoctoral Fellow; Poverty; Publications; Quality of life; Race; Research; Research Peer Review; Research Personnel; Resource Sharing; Risk; Risk Factors; Role; Rural; Strategic Planning; Symptoms; Tobacco Use Cessation; Tobacco use; Training; Treatment Side Effects; Underserved Population; Work; abuse liability; addiction; cancer care; cancer health disparity; cancer prevention; cancer risk; care coordination; chemobrain; community based participatory research; community engagement; community partnership; epidemiologic discoveries; experience; graduate student; improved; innovation; interdisciplinary collaboration; lung cancer screening; mHealth; member; metabolomics; mortality; novel; prevent; programs; racial population; recruit; response; rural area; rural cancer care; rural poverty; rural residence; screening; social; socioeconomic disadvantage; survivorship; synergism; tobacco prevention; tribal Nation; tumor progression; uptake

CANCER PREVENTION AND CONTROL PROGRAM: ABSTRACT The overall goal of the Cancer Prevention and Control (CPC) program is to understand and address high- impact cancers and cancer-related disparities in Oklahoma (SCC catchment area), with a focus on disparities in the state's American Indian (AI), Black / African American (Black/AA), rural, and other socioeconomically disadvantaged populations. Specific aims of the program focus on: 1) identifying genetic, environmental, behavioral, and social risk factors that contribute to high cancer incidence and disparities in Oklahoma; 2) developing, evaluating and implementing interventions to reduce to cancer incidence and mortality; and 3) improving cancer outcomes through enhancing care access, delivery and survivorship. Close interactions with the Community Outreach and Engagement (COE) Associate Director (Mark Doescher, MD) and Core help facilitate catchment area-focused research and community partnerships. CPC program aims have evolved since the last CCSG, driven by center and program planning, new strategic opportunities, maturation of program activities, and in response to emerging cancer problems in the catchment area. Revised program aims now reflect a broader scope as well as greater integration and synergy of activity to address cancer in the catchment area. The CPC program has 43 members (25 full and 18 associate), representing 18 academic departments and a range of transdisciplinary expertise, including: cancer health disparities, community-based participatory research; novel interventions for tobacco prevention and cessation; emerging tobacco products; basic mechanisms of addiction; care coordination, delivery and survivorship; and basic mechanisms of treatment- related side effects. The CPC program made significant progress during past five years on all metrics for programmatic activities. The CPC program has experienced significant increases in NCI ($2.64M  $3.65M) and total peer-reviewed research funding ($5.58M  $7.27M) since the last CCSG, reflecting strategic planning, targeted recruitment, allocation of developmental funds, and value-added support from the SCC. Key publication metrics have also significantly increased since the last CCSG, including: intra-programmatic (36%  40%), inter-programmatic (6%  29%), multi-institutional (64%  82%), and high impact (1%  8%) [impact factor ≥10]. The nearly five-fold increase in inter-programmatic collaborative publications directly addresses a program critique in the prior CCSG. The CPC program hosts numerous training and mentorship programs for under- and graduate students, postdoctoral fellows and junior faculty. The CPC program is led by Paul Spicer, PhD, Darla Kendzor, PhD, and C.V. Rao, PhD, who have diverse and complementary transdisciplinary expertise to advance program aims.

癌症预防和控制计划：摘要 癌症预防和控制 (CPC) 计划的总体目标是了解和解决高风险问题 影响俄克拉荷马州（SCC 流域）的癌症和与癌症相关的差异，重点关注差异 在该州的美洲印第安人 (AI)、黑人/非裔美国人 (Black/AA)、农村和其他社会经济方面 弱势群体。该计划的具体目标侧重于：1）识别遗传、环境、 导致俄克拉荷马州癌症高发病率和差异的行为和社会风险因素； 2） 制定、评估和实施干预措施以降低癌症发病率和死亡率；和 3) 通过改善护理机会、交付和生存来改善癌症结果。密切互动 社区外展和参与 (COE) 副总监（MarkDoscher，医学博士）和核心帮助 促进以流域为重点的研究和社区伙伴关系。 CPC 计划目标已发生变化 自上一届 CCSG 以来，在中心和项目规划、新的战略机遇、成熟的 计划活动，并应对流域内新出现的癌症问题。修改后的计划 现在的目标反映了更广泛的范围以及更大程度的整合和协同作用，以解决全球范围内的癌症问题 集水区。 CPC 项目有 43 名成员（25 名正式成员和 18 名副成员），代表 18 个学术部门和一个 一系列跨学科专业知识，包括：癌症健康差异、基于社区的参与 研究;预防和戒烟的新干预措施；新兴烟草产品；基本的 成瘾机制；护理协调、交付和生存；和治疗的基本机制- 相关的副作用。 CPC 计划在过去五年中在所有指标上都取得了重大进展 计划性活动。 CPC 计划的 NCI 显着增加（264 万美元 → 365 万美元） 自上次 CCSG 以来同行评审研究经费总额（558 万美元 → 727 万美元），反映了战略性 规划、定向招聘、发展资金分配以及SCC的增值支持。钥匙 自上次 CCSG 以来，出版指标也显着增加，包括： 程序内（36% → 40%)、跨项目(6% → 29%)、多机构(64% → 82%) 和高影响力(1% → 8%) [影响因子≥10]。跨项目合作出版物直接增加近五倍 解决了先前 CCSG 中的计划批评。 CPC 计划举办大量培训和指导 面向本科生和研究生、博士后研究员和初级教师的项目。中国共产党的纲领是由 Paul Spicer 博士、Darla Kendzor 博士和 C.V. Rao 博士，他们具有多元化和互补性 跨学科专业知识来推进计划目标。