Cancer Prevention and Control Program

癌症预防和控制计划

• 批准号: 10627032
• 负责人: Darla Elizabeth Kendzor
• 金额: $ 7.83万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627032
• 关键词: Address; African American; American Indians; Area; Basic Science; Behavioral; Behavioral Sciences; Black race; Cancer Center; Cancer Center Support Grant; Cancer Control; Catchment Area; Chemopreventive Agent; Clinical Sciences; Collaborations; Community Outreach; Complex; Continuance of life; Continuity of Patient Care; Critiques; DNA Damage; Development; Disease; Disparity; Doctor of Philosophy; Economically Deprived Population; Emerging Tobacco Products; Evaluation; Faculty; Financial Hardship; Funding; Future; Genetic; Genomics; Goals; Growth; Health Services Accessibility; Health behavior; Incentives; Incidence; Inflammatory; Institution; Intervention; Intervention Trial; Laboratories; Life Style Modification; Malignant Neoplasms; Menthol; Mentors; Mentorship; Monitor; NCI-Designated Cancer Center; Not Hispanic or Latino; Oklahoma; Outcome; Pain management; Pathway interactions; Peer Review; Play; Population; Population Sciences; Positioning Attribute; Postdoctoral Fellow; Poverty; Publications; Quality of life; Race; Research; Research Peer Review; Research Personnel; Resource Sharing; Risk; Risk Factors; Role; Rural; Strategic Planning; Symptoms; Tobacco Use Cessation; Tobacco use; Training; Treatment Side Effects; Underserved Population; Work; abuse liability; addiction; cancer care; cancer health disparity; cancer prevention; cancer risk; care coordination; chemobrain; community based participatory research; community engagement; community partnership; epidemiologic discoveries; experience; graduate student; improved; innovation; interdisciplinary collaboration; lung cancer screening; mHealth; member; metabolomics; mortality; novel; prevent; programs; racial population; recruit; response; rural area; rural cancer care; rural poverty; rural residence; screening; social; socioeconomic disadvantage; survivorship; synergism; tobacco prevention; tribal Nation; tumor progression; uptake

CANCER PREVENTION AND CONTROL PROGRAM: ABSTRACT The overall goal of the Cancer Prevention and Control (CPC) program is to understand and address high- impact cancers and cancer-related disparities in Oklahoma (SCC catchment area), with a focus on disparities in the state's American Indian (AI), Black / African American (Black/AA), rural, and other socioeconomically disadvantaged populations. Specific aims of the program focus on: 1) identifying genetic, environmental, behavioral, and social risk factors that contribute to high cancer incidence and disparities in Oklahoma; 2) developing, evaluating and implementing interventions to reduce to cancer incidence and mortality; and 3) improving cancer outcomes through enhancing care access, delivery and survivorship. Close interactions with the Community Outreach and Engagement (COE) Associate Director (Mark Doescher, MD) and Core help facilitate catchment area-focused research and community partnerships. CPC program aims have evolved since the last CCSG, driven by center and program planning, new strategic opportunities, maturation of program activities, and in response to emerging cancer problems in the catchment area. Revised program aims now reflect a broader scope as well as greater integration and synergy of activity to address cancer in the catchment area. The CPC program has 43 members (25 full and 18 associate), representing 18 academic departments and a range of transdisciplinary expertise, including: cancer health disparities, community-based participatory research; novel interventions for tobacco prevention and cessation; emerging tobacco products; basic mechanisms of addiction; care coordination, delivery and survivorship; and basic mechanisms of treatment- related side effects. The CPC program made significant progress during past five years on all metrics for programmatic activities. The CPC program has experienced significant increases in NCI ($2.64M  $3.65M) and total peer-reviewed research funding ($5.58M  $7.27M) since the last CCSG, reflecting strategic planning, targeted recruitment, allocation of developmental funds, and value-added support from the SCC. Key publication metrics have also significantly increased since the last CCSG, including: intra-programmatic (36%  40%), inter-programmatic (6%  29%), multi-institutional (64%  82%), and high impact (1%  8%) [impact factor ≥10]. The nearly five-fold increase in inter-programmatic collaborative publications directly addresses a program critique in the prior CCSG. The CPC program hosts numerous training and mentorship programs for under- and graduate students, postdoctoral fellows and junior faculty. The CPC program is led by Paul Spicer, PhD, Darla Kendzor, PhD, and C.V. Rao, PhD, who have diverse and complementary transdisciplinary expertise to advance program aims.

癌症预防与控制 癌症预防和控制（CPC）计划的总体目标是了解和解决高- 影响俄克拉荷马州（SCC集水区）的癌症和与癌症相关的差异，重点关注差异 在该州的美洲印第安人（AI），黑人/非裔美国人（黑人/AA），农村和其他社会经济 弱势群体。该计划的具体目标侧重于：1）识别遗传、环境， 导致俄克拉荷马州癌症高发率和差异的行为和社会风险因素; 2） 制定、评估和实施干预措施，以降低癌症发病率和死亡率;以及3） 通过提高护理的可及性、提供和生存率来改善癌症预后。密切互动 社区外展和参与（COE）副主任（Mark Doescher，MD）和核心帮助 促进以集水区为重点的研究和社区伙伴关系。CPC计划的目标已经演变 自上一届CCSG以来，在中心和项目规划、新的战略机遇、 计划活动，并应对集水区新出现的癌症问题。订正方案 目前的目标反映了在全球范围内解决癌症问题的活动范围更广， 集水区 CPC计划有43名成员（25名正式成员和18名准成员），代表18个学术部门和一个 一系列跨学科的专业知识，包括：癌症健康差距，社区参与 研究;烟草预防和戒烟的新干预措施;新兴烟草产品;基本 成瘾机制;护理协调、提供和生存;以及治疗的基本机制- 相关副作用。CPC计划在过去五年中在所有指标上取得了重大进展， 方案活动。CPC计划在NCI（264万美元至365万美元）中经历了显着增长 自上次CCSG以来，同行评审的研究资金总额（558万至727万美元），反映了战略 规划、有针对性的招聘、发展资金的分配以及SCC的增值支持。关键 自上一届CCSG以来，出版指标也有了显著提高，其中包括：计划内（36%） 40%）、跨计划（6%至29%）、多机构（64%至82%）和高影响力（1%至8%） [影响因子≥10]。方案间合作出版物增加近五倍， 解决了先前CCSG中的一个程序批评。CPC计划举办了许多培训和指导 为本科生和研究生、博士后研究员和初级教师提供的课程。CPC计划由 Paul斯派塞，博士，Darla Kendzor，博士和C. V. Rao，博士，他们有不同的和互补的 跨学科的专业知识，以推进计划的目标。