Training in Basic and Translational Digestive Sciences

摘要 本申请旨在续订NIH T32基础和翻译消化科学培训，即 目前已进入第10个年头。密歇根大学在胃肠训练方面有着卓越的历史 过去几十年的科学研究，包括内科和非内科科学家。2012年，我们 启动了一项培训计划，重点是培训博士后临床研究员(医学博士、医学博士/博士)与 对基础消化科学和翻译消化科学感兴趣的博士前博士后候选人。培训 该计划包括26名由NIH资助的教师导师，其中包括12名临床活跃的内科科学家和14名非 临床教员，来自临床和基础科学系：内科(13)， 分子与综合生理学(6)、病理学(3)、微生物学与免疫学(3)、外科(1)。我们的 该计划整合了从事胃肠道基础研究和翻译工作的主要研究人员 密歇根大学医学院研究成为培养内科医生的强大核心导师 对胃肠科学研究事业感兴趣的科学家和生物医学研究人员。我们这群人 26名培训计划教职员工也是由NIH资助的密歇根消化疾病核心中心的成员 (P30 DK34933)，并带来了合作和团队科学的悠久历史。我们的T32培训 该计划侧重于三个主题领域，这些领域在 参与机制：1)细胞命运、可塑性、再生和转化的机制；2)系统的， 细胞和营养代谢；3)对宿主-环境-微生物的免疫和炎症反应 互动。要求继续为3名博士前实习生提供支持，他们正在攻读下列项目之一的博士学位 学科范围从生理学、微生物学和免疫学，到细胞和分子生物学，以及2 胃肠病学博士后同行实习生。该计划由医学博士钟欧阳联合指导(分部 消化内科)和Linda Samuelson博士(分子和医学系 综合生理学)，包括每周一次的胃肠道科学研讨会系列(内部和外部演讲者)， 受训人员研究报告、负责任地进行研究和研究重复性方面的培训；以及 强有力的辅导和职业发展指导。学员研究将得到超过20美元的支持 每年授予培训教师数百万美元的研究经费，加上大量的机构 支持直接支持受训人员和项目。可利用的数量和多样性的组合 资源，我们过去的培训记录，以及培训人员表现出的卓越表现，提供了强大的 这一计划将继续在培训下一代调查人员方面取得巨大成功的证据 对基础消化科学和翻译消化科学感兴趣。

ABSTRACT This application seeks to renew the NIH T32 Training in Basic and Translational Digestive Sciences that is currently in its 10th year. The University of Michigan has a superb history of training in gastrointestinal sciences over the last several decades, including both physician and non-physician scientists. In 2012 we initiated a training program that focused on training postdoctoral clinical fellows (MD, MD/PhD) together with predoctoral PhD candidate scientists interested in basic and translational digestive sciences. The Training Program includes 26 NIH-funded faculty mentors, including 12 clinically active physician scientists and 14 non- clinical faculty members, who come from clinical and basic science departments: Internal Medicine (13), Molecular & Integrative Physiology (6), Pathology (3), Microbiology & Immunology (3), and Surgery (1). Our program consolidates the major investigators who are conducting gastrointestinal basic and translational research at the University of Michigan Medical School into a strong core of mentors for the training of physician scientists and biomedical investigators interested in a research career in gastrointestinal science. Our group of 26 training program faculty are also members of the Michigan Digestive Diseases Core Center funded by NIH (P30 DK34933) since 1986 and bring a long history of collaboration and team science. Our T32 training program focuses on three thematic areas that provide exceptional cross-disciplinary collaboration amongst the participating faculty: 1) mechanisms of cell fate, plasticity, regeneration, and transformation; 2) systemic, cellular, and nutrient metabolism; 3) immune and inflammatory responses to host-environment-microbial interactions. Continued support is requested for 3 predoctoral trainees seeking PhDs in one of a number of disciplines that range from Physiology, Microbiology & Immunology, to Cell & Molecular Biology, and for 2 postdoctoral Gastroenterology Fellow trainees. The Program, co-directed by Chung Owyang, MD (Division of Gastroenterology, Department of Internal Medicine) and Linda Samuelson, PhD (Department of Molecular & Integrative Physiology), includes a weekly seminar series in GI science (both internal and external speakers), trainee research presentations, training in responsible conduct of research and research reproducibility, and strong mentoring and career development guidance. Trainee research will be supported by more than $20 million of annual research funding awarded to the training faculty combined with substantial institutional support to directly support the trainees and the Program. The combined mass and diversity of available resources, our past training record, and the demonstrated excellence of the training faculty provide strong evidence that this program will continue to be highly successful in training the next generation of investigators interested in basic and translational digestive sciences.