Research Projects Core

研究项目核心

• 批准号: 10628977
• 负责人: Walter I Silva
• 金额: $ 17.37万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628977
• 关键词: Affect; Agreement; Alcohols; Alzheimer' s Disease; Area; Award; Behavior; Biological Models; Brain; Centers of Research Excellence; Core Facility; Development; Dimensions; Disease; Educational workshop; Electrophysiology (science); Entrepreneurship; Environment; Equipment; Evaluation; Evolution; Experimental Models; Fostering; Funding; Funding Agency; Goals; Government; Grant; Health; Individual; Industry; Infrastructure; Institution; Investigator-Initiated Research; Legal patent; Measures; Methodology; Modality; Modeling; Modernization; Nature; Nerve Tissue; Nervous System; Neurodegenerative Disorders; Neuronal Plasticity; Neurosciences; Neurosciences Research; New Agents; Outcome; Parkinson Disease; Participant; Phase; Pilot Projects; Population; Productivity; Publications; Puerto Rico; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Scientist; Series; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Source; Teacher Professional Development; Therapeutic; Training; Training and Education; United States National Institutes of Health; Universities; addiction; base; career development; combat; disability; equipment acquisition; higher education; instrumentation; neuroimaging; neuroinflammation; next generation; novel; novel strategies; programs; skill acquisition; success; synergism; tissue injury; tissue trauma; translational applications

Project Summary/Abstract The UPR Phases 1 and 2 CCfN significantly contributed to advancement of research in Puerto Rico. A key component has been the investigator-initiated research projects: Phase 1 and 2 Subprojects, and Phase 2 Pilot and Collaborative Seed Projects. The CCfN supported a total of 21 investigator-initiated research projects: 10 Subprojects, 4 Pilot, and 7 Seed projects. These projects impacted scientists from 5 institutions and 8 academic departments. These entailed a rich diversity of Neuroscience research themes, experimental model systems, approaches and methodology. In terms of scientific productivity COBRE-funded PIs (Subprojects, Pilots and Seeds) accounted for ~50% of the 113 total publications of the CCfN and contributed to 41% (745) of the citations total (1816). A total of ~$15M in external funds were obtained by these investigators. Subprojects accounted for 52 of the 83 grants submitted (~63%) and 27 of the 48 funded (~56%). COBRE Phase 2 Pilot and Seed projects accounted for 37.4% of grants submitted and 43% of grants funded for ~$4,25M or 36.3% of the total external funds obtained by these projects. Phase 3 CCfN seeks expansion and evolution of investigator-initiated research into a Research Projects Core (RPC) that further evidences the inherent and emerging synergism between the CCfN’s Administrative Core, Neuroimaging and Electrophysiology Facilities (NIEF), and Research Projects Core. Phase 3 RPC specifically aims to: (1) continue providing support for investigator-initiated research projects in the modalities of Pilot and Seed projects. RPC will continue support of Pilots and Seed projects, with an expanded potential user population and academic institutions. Scope will also be expanded to more Neuroscience-related research themes and entrepreneurship. Most importantly, all Seed Projects funds (5K/Seed, 25K/yr, 125K complete grant cycle) and equipment purchases during the first year of each Pilot project will derive entirely from institutional commitment funds; (2) further enhance the development of COBRE investigators’ productivity and competitiveness by their participation in programmatic activities sponsored by the Administrative and NIEF Cores. Pilot Projects participants are required to participate in the capabilities’ enhancement activities of the Administrative CORE and other applicable NIEF education and training sessions; and, (3) sponsor the submission of Neuroplasticity and related neuroscience research grants to competitive sources of research funding, including individual, multiple-PI, program project or center grants from other NIH Institutes and Centers, or other Federal and non-Federal entities. We aim to facilitate submission of multiple-PI, program project, or center grants based on areas of research strength. Given our diversity of neuroscientists and expertise we envision their coalescence into next-level collaborative research venues. The RPC will further the programmatic goals of fostering development of researchers, enhancing competitiveness, promoting continued development of a competitive research culture, and becoming a world- recognized self-sustainable Center for Neuroplasticity with emerging translational/therapeutic applications.

项目总结/摘要 普遍定期审议第一阶段和第二阶段的加勒比国家森林委员会为推动波多黎各的研究作出了重大贡献。一个关键 其中一个组成部分是由该委员会发起的研究项目：第一阶段和第二阶段的子项目，以及第二阶段的试点项目 合作种子项目。CcfN共支持了21个由制药商发起的研究项目： 子项目、4个试点项目和7个种子项目。这些项目影响了来自5个机构和8个学术机构的科学家。 部门这需要丰富多样的神经科学研究主题，实验模型系统， 方法和方法。在科学生产力方面，COBRE-Funded PI（子项目、试点项目和 种子）占CCfN 113篇出版物的约50%，占引文的41%（745 共计（1816）。这些调查人员总共获得了约1500万美元的外部资金。次级项目占 83项赠款中有52项（约63%）提交，48项赠款中有27项（约56%）获得资助。COBRE第2阶段试点和种子项目 占提交赠款的37.4%，占资助赠款的43%，约为42.5百万美元，占外部赠款总额的36.3%。 这些项目获得的资金。第三阶段CcfN寻求扩展和发展的研究 纳入研究项目核心（RPC），进一步证明了 CCfN的行政核心，神经影像和电生理设施（NIEF），和研究项目的核心。 第三阶段RPC的具体目标是：（1）继续为制药商发起的研究提供支持 以试点项目和种子项目的方式开展项目。RPC将继续支持试点和种子项目， 扩大了潜在的用户群体和学术机构。范围也将扩大到更多 神经科学相关的研究主题和创业精神。最重要的是，所有种子项目基金 (5K/种子，25 K/年，125 K完整的赠款周期）和设备购买在每个试点项目的第一年 将完全来自机构承诺资金;（2）进一步加强COBRE的发展 调查员通过参与方案活动提高生产力和竞争力 由行政和NIEF核心赞助。试点项目参与者必须参加 行政核心和其他适用的NIEF教育的能力增强活动， 培训课程;以及（3）赞助提交神经可塑性和相关神经科学研究 研究资金的竞争性来源，包括个人，多PI，计划项目或 其他NIH研究所和中心或其他联邦和非联邦实体的中心赠款。我们的目标是 促进提交多PI，计划项目，或基于研究实力领域的中心赠款。给定 我们的神经科学家和专业知识的多样性，我们设想他们的合并到下一个层次的合作研究 场地RPC将进一步促进促进研究人员发展的方案目标， 竞争力，促进竞争性研究文化的持续发展，并成为一个世界- 公认的自我可持续的神经可塑性中心与新兴的翻译/治疗应用。