MBRS-SCORE Program at UPR-Medical Sciences Campus

描述（由申请人提供）：UPR-MSC的MBRS SCORE计划的补充申请扩大了母计划提供的生物医学研究的支持范围，从而加强了其实现协助教师开发有竞争力的研究项目的总体目标的能力，并增加了专业从事生物医学，临床和行为研究的代表性不足的少数民族的数量。作为我们最近竞争性更新过程的结果，UPR-MSC的MBRS SCORE计划目前由16个项目组成（13个常规项目和3个试点项目）。SCORE计划在其2004-2008年新的供资周期中，构成了一个整合了MSC六所学校和学院中三所的调查人员的计划。该计划支持的主要研究重点领域是：传染病，神经科学，细胞生物学，癌症和分子毒理学。在这个补充的调查人员和项目的新干部将通过增加现有的主要研究重点领域的PI的质量补充目前的母赠款。此外，通过提交突触可塑性和神经药理学，细胞和衰老分子生物学的神经科学项目，进一步扩大了这些领域内研究课题的多样性。该补充还增加了科学研究领域的多样性，提交了一个心血管生理学项目和两个药物科学项目。从药学院纳入两个项目也将允许扩大到四个参与学校和学院从MSC的总数。具体而言，该补充寻求支持11个项目（7个常规项目和4个试点项目），包括新的和/或临床教师以及处于不同专业发展阶段的教师。这些科学家的多样性赋予了该计划一个扩展的研究议程，这反过来又影响了MBRS SCORE计划的使命和目标的发展。因此，对所有申请人的进一步支持被认为是UPR-MSC和国家MBRS SCORE计划的重要附加值和资产增值。一旦授予，潜在的PI档案将产生一个对职业发展的所有阶段敏感的SCORE计划，但主要针对最高发展援助范围末端的PI。此外，根据项目中PI对分子生物学方法和技术的记录和增加的需求，要求支持分子核心实验室技术员剩余的50%工资。

DESCRIPTION (provided by applicant): This supplemental application to the UPR-MSC's MBRS SCORE Program expands the scope of support for biomedical research provided by the parent program, thereby strengthening its ability to attain the overall goal of assisting faculty to develop competitive research programs, and increasing the number of underrepresented minorities professionally engaged in biomedical, clinical and behavioral research. As an outcome of our recent competing renewal process, the MBRS SCORE Program at the UPR-MSC is currently composed of 16 projects (13 regular and 3 pilots). The SCORE Program, in its new funding cycle 2004-2008, constitutes a program that integrates investigators from three out of the six MSC's schools and colleges. The main research focus areas supported by the program are: Infectious Diseases, Neurosciences, Cell Biology, Cancer, and Molecular Toxicology. The new cadre of investigators and projects in this supplement will complement the current parent grant by increasing the mass of PIs in the existing main research focus areas. In addition, the diversity of research topics within these areas is further expanded by the submission of projects in the neurosciences of synaptic plasticity and neuropharmacology, cell and molecular biology of aging. The supplement also increases the diversity of scientific research areas, with the submission of one project in Cardiovascular Physiology, and two projects in Pharmaceutical Sciences. The inclusion of two projects from the School of Pharmacy will also permit expanding to four the total number of participating schools and colleges from the MSC. Specifically, the supplement seeks support for 11 projects (7 regular and 4 pilots) to include new and/or clinical faculty as well as faculty who are at diverse stages of professional development. The diversity of these scientists endows the program with an expanded research agenda, which in turn impacts the development of the mission and goals of the MBRS SCORE program. Further support of all applicants in this supplement is consequently envisioned as a significant added value and asset accrual for the UPR-MSC's and national MBRS SCORE Programs. Once awarded, the prospective PI profile will result in a SCORE Program sensitive to all stages of career development, yet primarily addressing PIs at the end of the spectrum of highest developmental assistance. In addition, support for the remaining 50% salary of the Molecular Core Lab Technician is requested, as deemed appropriate by the documented and increased demand for molecular biology approaches and techniques by PIs in the Program.