Core 2: Data Science Core

核心2，数据科学-摘要 数据科学核心(核心2)的目的是提供全面的、多学科的资源，包括 生物统计学和生物信息学方面的专业知识。核心2号的成员将与调查人员密切合作 从每个项目中将其生物学假说转化为可检验的统计假说，并解决 相应的目标是各级调查。这包括设计实验室和动物实验， 存储和管理所产生的数据、统计和生物信息学数据分析 预先测试分析管道，挖掘和整合公共数据，并根据以下条件制定新的假设 综合数据的勘探和可视化所产生的发现。核心2作为焦点 在这一点上，调查人员可以得到统计和生物信息学专业知识的协助，以进行规划， 管理，并分析他们的研究。它还开发、测试和实现各种统计和 计算技术，包括特别关注癌症研究的数学建模。类型 支持的研究包括基础科学、转化研究和组学数据分析。大容量的 要在拟议的研究项目和核心中产生的信息需要计算机引导的方法 用于协调努力和管理数据。核心2的主要作用将包括建立 集中式关系数据库系统和数据管理结构，便于输入、存储和 检索方案项目产生的所有数据，并允许有控制的信息交换 所有的项目和核心。与此相关的所有调查人员都将获得未确认身份的信息 计划项目补助金(PPG)。由于酷睿2存储的信息的敏感性，我们将 采取广泛的预防措施保护参与者的机密性。所有IRB和HIPAA法规都将 严格执行。通过向调查人员提供数据访问，共享技术能力，并确保质量 在数据方面，这一核心的数据管理部分将有助于实现项目目标和 鼓励进行超出规定的探索性分析。

CORE 2, DATA SCIENCE – SUMMARY The purpose of the Data Science Core (Core 2) is to provide a comprehensive, multi-disciplinary resource with expertise in biostatistics and bioinformatics. Members of the Core 2 will collaborate closely with investigators from each project in translating their biological hypotheses into testable statistical hypotheses and address the corresponding aims at all levels of investigation. This consists of designing laboratory and animal experiments, storing and managing the resulting data, statistical and bioinformatics data analyses using well-established and pre-tested analysis pipelines, mining and integration of public data, and formulating new hypotheses based on discoveries arising from exploration and visualization of the integrated data. The Core 2 serves as a focal point from which investigators may be assisted with statistical and bioinformatics expertise for planning, management, and analysis of their studies. It also develops, tests, and implements various statistical and computational techniques, including mathematical modeling with special focus on cancer research. Types of research supported include basic science, translational research, and omics data analysis. The large volume of information to be generated in the proposed research projects and cores requires computer-guided approaches for coordination of efforts and management of data. The primary role of the Core 2 will include establishing a centralized relational database system and data management structure that facilitate entry, storage and retrieval of all data generated by the program projects and permits the controlled exchange of information across the projects and cores. De-identified information will be available to all investigators associated with this Program Project Grant (PPG). Due to the sensitive nature of the information stored by the Core 2, we will take extensive precautions to protect the confidentiality of participants. All IRB and HIPAA regulations will be strictly enforced. By providing data access to investigators, sharing technical capabilities, and ensuring the quality of the data, the data management component of this core will facilitate achievement of the project aims and encourage exploratory analyses beyond those stated.