Core 2: Data Science Core

核心 2：数据科学核心

• 批准号: 10629083
• 负责人: SUNGYONG YOU
• 金额: $ 24.2万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629083
• 关键词: Achievement; Address; Animal Experiments; Basic Science; Bioinformatics; Biological; Biometry; Chromosomes; Collaborations; Computational Technique; Computer Analysis; Computer software; Computers; Data; Data Analyses; Data Science; Data Science Core; Data Storage and Retrieval; Database Management Systems; Databases; Development; Ensure; Experimental Designs; Goals; Health Insurance Portability and Accountability Act; Immunity; Institutional Review Boards; Investigation; Malignant neoplasm of urinary bladder; Manuscripts; Methodology; Mining; Multiomic Data; Nature; Outcome; Participant; Pathology; Patients; Procedures; Program Research Project Grants; Randomized; Regulation; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Retrieval; Role; Sample Size; Specimen; Standardization; Structure; System; Testing; Translating; Translational Research; Visualization; Writing; analysis pipeline; anticancer research; central database; computerized data processing; computerized tools; data access; data analysis pipeline; data harmonization; data integration; data management; data quality; design; experimental study; laboratory experiment; mathematical model; member; multidisciplinary; preservation; programs; relational database; research study; sex

CORE 2, DATA SCIENCE – SUMMARY The purpose of the Data Science Core (Core 2) is to provide a comprehensive, multi-disciplinary resource with expertise in biostatistics and bioinformatics. Members of the Core 2 will collaborate closely with investigators from each project in translating their biological hypotheses into testable statistical hypotheses and address the corresponding aims at all levels of investigation. This consists of designing laboratory and animal experiments, storing and managing the resulting data, statistical and bioinformatics data analyses using well-established and pre-tested analysis pipelines, mining and integration of public data, and formulating new hypotheses based on discoveries arising from exploration and visualization of the integrated data. The Core 2 serves as a focal point from which investigators may be assisted with statistical and bioinformatics expertise for planning, management, and analysis of their studies. It also develops, tests, and implements various statistical and computational techniques, including mathematical modeling with special focus on cancer research. Types of research supported include basic science, translational research, and omics data analysis. The large volume of information to be generated in the proposed research projects and cores requires computer-guided approaches for coordination of efforts and management of data. The primary role of the Core 2 will include establishing a centralized relational database system and data management structure that facilitate entry, storage and retrieval of all data generated by the program projects and permits the controlled exchange of information across the projects and cores. De-identified information will be available to all investigators associated with this Program Project Grant (PPG). Due to the sensitive nature of the information stored by the Core 2, we will take extensive precautions to protect the confidentiality of participants. All IRB and HIPAA regulations will be strictly enforced. By providing data access to investigators, sharing technical capabilities, and ensuring the quality of the data, the data management component of this core will facilitate achievement of the project aims and encourage exploratory analyses beyond those stated.

核心2，数据科学-总结 数据科学核心（核心2）的目的是提供全面的，多学科的资源， 生物统计学和生物信息学方面的专门知识。核心2的成员将与调查人员密切合作 从每个项目中将他们的生物学假设转化为可检验的统计学假设，并解决 在各级调查中有相应的目标。这包括设计实验室和动物实验， 存储和管理产生的数据，统计和生物信息学数据分析，使用完善的， 预先测试的分析管道，挖掘和整合公共数据，并根据 从综合数据的探索和可视化中获得的发现。核心2作为焦点 研究者可以从这一点获得统计和生物信息学专业知识的帮助， 管理和分析他们的研究。它还开发，测试和实施各种统计和 计算技术，包括数学建模，特别关注癌症研究。类型的 支持的研究包括基础科学，转化研究和组学数据分析。的大量 在拟议的研究项目和核心中产生的信息需要计算机指导的方法 协调工作和管理数据。核心2的主要作用将包括建立 一个集中的关系数据库系统和数据管理结构，便于输入、存储和 检索由计划项目产生的所有数据，并允许受控的信息交换 跨项目和核心。去识别信息将提供给所有与此相关的研究者 计划项目补助金（PPG）。由于Core 2存储的信息的敏感性，我们将 采取广泛的预防措施来保护参与者的机密性。所有IRB和HIPAA法规将 严格执行通过向调查人员提供数据访问，共享技术能力，并确保质量， 该核心的数据管理部分将促进项目目标的实现， 鼓励进行超出上述范围的探索性分析。